Results 61 to 70 of about 97,116 (340)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Delivery as nanoparticles reduces imatinib mesylate-induced cardiotoxicity and improves anticancer activity [PDF]

, 2015
Clinical effectiveness of imatinib mesylate in cancer treatment is compromised by its off-target cardiotoxicity. In the present study, we have developed physically stable imatinib mesylate-loaded poly(lactide-co-glycolide) nanoparticles (INPs) that could
Balakumar, Krishnamoorthy, Franklin, Gregory, Khandelwal, Vinoth Kumar Megraj, Marslin, Gregory, Prakash, Jose, Revina, Ann Mary, Sheeba, Caroline Jeya   +6 more
core   +2 more sources

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Understanding Anthracycline Cardiotoxicity From Mitochondrial Aspect

Frontiers in Pharmacology, 2022
Anthracyclines, such as doxorubicin, represent one group of chemotherapy drugs with the most cardiotoxicity. Despite that anthracyclines are capable of treating assorted solid tumors and hematological malignancies, the side effect of inducing cardiac ...
Junqi Huang, Rundong Wu, Linyi Chen, Ziqiang Yang, Daoguang Yan, Mingchuan Li   +5 more
doaj   +1 more source

Docetaxel induced cardiotoxicity [PDF]

Heart, 2001
Docetaxel is a new taxoid antineoplastic agent.1 2Its mechanism of action is primarily related to its ability to enhance microtubule assembly and to stabilise microtubules by preventing their depolymerisation, thus disrupting normal cell division.2Since docetaxel has significant cytotoxic activity against human breast cancer in vitro and in vivo, it is
M, Shimoyama, Y, Murata, K I, Sumi, R, Hamazoe, I, Komuro   +4 more
openaire   +2 more sources

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]

, 2019
Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core  

Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments

Frontiers in Cardiovascular Medicine, 2022
As a result of ongoing breakthroughs in cancer therapy, cancer patients' survival rates have grown considerably. However, cardiotoxicity has emerged as the most dangerous toxic side effect of cancer treatment, negatively impacting cancer patients ...
Wanli Sun, Juping Xu, Li Wang, Yuchen Jiang, Jingrun Cui, Xin Su, Fan Yang, Li Tian, Zeyu Si, Yanwei Xing   +9 more
doaj   +1 more source

Anthracycline-Induced Cardiotoxicity [PDF]

Acta Medica (Hradec Kralove, Czech Republic), 2000
Anthracycline antibiotics are among the most effective and widely used antineoplastic drugs. Their usefulness is limited by a cumulative dose-related cardiotoxicity, whose precise mechanisms are not clear as yet. The principal role is possibly exerted by free oxygen radicals generated by “redox-cycling“ of anthracycline molecule and/or by the formation
Radomír Hrdina, Vladimír Geršl, Ivona Klimtová, Tomáš Šimůnek, Jarmila Macháčková, Michaela Adamcová   +5 more
openaire   +3 more sources

Oleoylethanolamide as a New Therapeutic Strategy to Alleviate Doxorubicin-Induced Cardiotoxicity [PDF]

, 2022
Yeyu Qin, Jing Xie, Ruihe Zheng, Yuhang Li, Haixia Wang   +4 more
openalex   +1 more source