Results 151 to 160 of about 3,242,366 (329)

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Association between systemic immune-inflammation index and cardiovascular-kidney-metabolic syndrome

Scientific Reports
This study aims to explore the relationship between the Systemic Immune-Inflammation Index (SII) and Cardiovascular-Kidney-Metabolic (CKM) Syndrome and its components.
Chenxuan Gao, Shizhen Gao, Ren-Pei Zhao, Pei-Min Shen, Xiaorui Zhu, Ya-Ne Yang, Conghao Duan, Yansi Wang, Huan Ni, Lanping Zhou, Yunfang Xiang, Meiju Li, Zhao Xu, Yibing Wang, Haijie Yang, Chuanwei Zhao   +15 more
semanticscholar   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Association of serum Klotho with the severity and mortality among adults with cardiovascular-kidney-metabolic syndrome

Lipids in Health and Disease
Background Cardiovascular-kidney-metabolic (CKM) syndrome is characterized as a systemic disease resulting from the pathophysiological interplay among metabolic risk factors, chronic kidney disease (CKD), and cardiovascular disease (CVD).
Jiao Tang, Zhehao Xu, Li Ren, Jiahua Xu, Xin Chen, Yian Jin, Ruiyun Liang, Huanji Zhang   +7 more
doaj   +1 more source

Association of the triglyceride-glucose index combined with a body shape index with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome stage 0–3: findings from two prospective cohorts

Cardiovascular Diabetology
The triglyceride-glucose (TyG) index, as a measure of insulin resistance, has been confirmed to be associated with adverse clinical outcomes. The new composite indicator, TyG-A body type index (TyG-ABSI), by integrating the TyG index and the A body type ...
Mingjie Chen, Jiajie Guo, Yuwen Shangguan, Zhonghua Sun, Xue-Ling He, Qiang Tu, Qingkai Yan   +6 more
semanticscholar   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Estimated glucose disposal rate and mortality risk in cardiovascular–kidney–metabolic syndrome: a population-based study

BMC Endocrine Disorders
Background Cardiovascular–kidney–metabolic (CKM) syndrome is a systemic disorder characterized by the interrelated dysfunction of metabolic abnormalities, chronic kidney disease, and cardiovascular injury, significantly increasing the risk of ...
Zheng Zhang, Chao Fu, Yiyi Chai, Yanrong Gu, Xiaomin Wu, Dou Zhu, Ping Lin, Bo Yu, Ling Li   +8 more
doaj   +1 more source

Baseline Body Mass Index Category and Incident Treated Hypertension in Australian Men: A Linked Prospective Cohort Study Using PBS/MBS Data

Chronic Diseases and Translational Medicine, EarlyView.
Kaplan–Meier hypertension‐free survival by baseline body mass index category, primary adult cohort (men aged ≥ 18 years, n = 12,742). Time since baseline in years is plotted on the horizontal axis and the probability of remaining free of treated hypertension is plotted on the vertical axis. Numbers at risk are shown beneath the plot.
Ebenezer Afrifa‐Yamoah
wiley   +1 more source

Cholesterol Goal Attainment in Hypertensive Patients: the Impact of Metabolic Syndrome Components

, 2012
Background: Hypertension and dyslipidemia are potentially modifiable cardiovascular risk factors.Methods: We studied hypertensive outpatients regarding goal attainment in controlling dyslipidemia, according to individual cardiovascular risk profile ...
Batista, Marcelo Costa, Ribeiro, Hercules Ferreira, Oliveira Rodrigues, Cassio Jose de [UNIFESP], Zanella, Maria Teresa, Ribeiro, Artur Beltrame   +4 more
core   +1 more source

Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models.

Kidney International
INTRODUCTION Patients with metabolic syndrome and heart failure (HF) often have accompanying kidney dysfunction, which was recently defined as cardiovascular-kidney-metabolic (CKM) syndrome.
Eliza Bollinger, George Williams, Mary Piper, Kimberly L. Steen, Kelly Tam Neale, Xian Chen, Mackenzie Marshall, S. Jagarlapudi, Y. Jami-Alahmadi, Pierre M. Jean-Beltran, LouJin Song, Joshua Chiou, F. Geoly, Sarah R. Vargas, Ying Zhang, Elaine Kuang, Daniel Callahan, John C. Stansfield, Max Russo, John D. Griffin, Zhongyuan Sun, Melissa R Miller, Craig L. Hyde, Michelle F. Clasquin, Katherine Hales, Natalie A. Daurio, Justin D. Crane, D. Hirenallur-Shanthappa, John D. Groarke, Bei B. Zhang, Rachel J. Roth Flach   +30 more
semanticscholar   +1 more source