Results 61 to 70 of about 227,343 (293)

Interpretation of A Focus Shift From Sarcopenia to Muscle Health in the Asian Working Group for Sarcopenia 2025 Consensus Update

AGING MEDICINE, EarlyView.
The AWGS 2025 consensus shifts focus from diagnosing sarcopenia to promoting muscle health across the lifespan. It simplifies diagnosis to low muscle mass plus low strength, expands screening to middle‐aged adults, and integrates muscle health into the WHO ICOPE framework for early intervention and healthy aging.
Bi Jianghan, Li Jiaojiao, Kang Lin
wiley   +1 more source

Machine Learning‐Driven Digital Twin of a Field‐Effect Transistor‐Based Hormone Biosensor for Real‐Time Estradiol Monitoring

Advanced Intelligent Systems, EarlyView.
A machine learning‐driven digital twin simulates an aptamer‐functionalized BioFET measuring 17β‐estradiol. Real‐time Isd signals are processed, features are extracted, and trained models estimate hormone concentration. In parallel, a one‐step‐ahead forward model learns biosensor dynamics and generates realistic synthetic signals, enabling in silico ...
Anastasiia Gorelova, Alexandra Parichenko, Shirong Huang, Santiago Melia, Gianaurelio Cuniberti   +4 more
wiley   +1 more source

A holistic approach to managing cardio-kidney metabolic syndrome: insights and recommendations from the Italian perspective

Frontiers in Cardiovascular Medicine
Cardio-kidney metabolic (CKM) syndrome represents a complex and circular interplay of cardiovascular, renal, and metabolic dysfunctions, significantly contributing to global morbidity and mortality.
Massimo Iacoviello, Mauro Gori, Giuseppe Grandaliano, Giuseppe Grandaliano, Roberto Minutolo, Dario Pitocco, Roberto Trevisan, Roberto Trevisan   +7 more
doaj   +1 more source

Pre-pregnancy predictors of hypertension in pregnancy among Aboriginal and Torres Strait Islander women in north Queensland, Australia; a prospective cohort study [PDF]

, 2013
BACKGROUND Compared to other Australian women, Indigenous women are frequently at greater risk for hypertensive disorders of pregnancy. We examined pre-pregnancy factors that may predict hypertension in pregnancy in a cohort of Aboriginal and Torres ...
Adrian Esterman, B Jim, B McCulloch, B Sibai, C De Costa, C Hatzis, C Rudra, CL Roberts, D Jacobs, D Leonard, D Trewin, G Miller, G Zavorsky, H Abenhaim, I Mertens, J Neter, J Roberts, J Roberts, J Roberts, John Lynch, K Duckitt, K Joseph, K O’Dea, K Panaretto, KL Coyne, L Callaway, M Lindheimer, M Samuels-Kalow, R McDermott, Robyn McDermott, S Campbell, Sandra K Campbell, V Flenady, V Rodie, W Gilbert, W Hoy, World Health Organisation   +36 more
core   +2 more sources

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Social Determinants of Health in the Development of Cardiovascular-kidney-metabolic Syndrome

Reviews in Cardiovascular Medicine
Cardiovascular-kidney-metabolic (CKM) syndrome is characterized by the interactions among the metabolic risk factors, chronic kidney diseases (CKD) and cardiovascular diseases (CVD).
Xinyi Cai, Tuo Li
doaj   +1 more source

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

Animal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin, Kovit Pattanapanyasat, Sarawut Kumphune   +2 more
wiley   +1 more source

CARDIAL-MS (CArdio-Renal-DIAbetes-Liver-Metabolic Syndrome): a new proposition for an integrated multisystem metabolic disease

Diabetology & Metabolic Syndrome
Background Metabolic Syndrome—a constellation of insulin resistance, cardiovascular risk factors as hyperglycemia, hypertension, and dyslipidemia, and systemic metabolic dysfunction—may be driven by dysregulation of adipose tissue, which manifests as ...
Amélio F. Godoy-Matos, Cynthia Melissa Valério, Wellington S. Silva Júnior, João Marcello de Araujo-Neto, Andrei C. Sposito, José Hermógenes Rocco Suassuna   +5 more
doaj   +1 more source

From Cardiovascular-Kidney-Metabolic Syndrome to Cardiovascular-Renal-Hepatic-Metabolic Syndrome: Proposing an Expanded Framework

Biomolecules
Cardiometabolic diseases represent an escalating global health crisis, slowing or even reversing earlier declines in cardiovascular disease (CVD) mortality.
Nikolaos Theodorakis, Maria Nikolaou
doaj   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source