Results 61 to 70 of about 3,440,112 (288)

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Mechanism-based therapeutic strategies in cardiovascular-kidney-metabolic syndrome: integrating biological pathways with evidence from clinical trials

Frontiers in Endocrinology
Cardiovascular-kidney-metabolic (CKM) syndrome describes the close relationship between metabolic dysfunction, chronic kidney disease, and cardiovascular disease, which share several biological pathways and frequently progress together.
John Nzobokela, Simweene C. Choolwe, Sepiso K. Masenga, Sepiso K. Masenga, Sepiso K. Masenga   +4 more
doaj   +1 more source

Prevalence of cardiovascular-kidney-metabolic syndrome in Korea: Korea National Health and Nutrition Examination Survey 2011-2021 [PDF]

Epidemiology and Health
OBJECTIVES The American Heart Association (AHA) recently defined cardiovascular-kidney-metabolic (CKM) syndrome to better characterize the associations among cardiovascular, kidney, and metabolic diseases. Although about 9 in 10 United States adults have
Sung-Bin Hong, Ji-Eun Kim, Seung Seok Han, Joseph J. Shearer, Jungnam Joo, Ji-Yeob Choi, Véronique L. Roger   +6 more
doaj   +1 more source

Is Socioeconomic Position Related to the Prevalence of Metabolic Syndrome? Influence of social class across the life course in a population-based study of older men [PDF]

, 2008
OBJECTIVE - To examine whether adult social class and childhood social class are related to metabolic syndrome in later life, independent of adult behavioral factors.RESEARCH DESIGN AND METHODS - This was a population-based cross-sectional study ...
Morris, R, Lennon, Lucy, Whincup, Peter H, Whincup, PH, Morris, Richard, Ramsay, SE, Lennon, L, Ramsay, Sheena E, Wannamethee, S G, Wannamethee, SG   +9 more
core   +1 more source

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Longitudinal trajectories of serum uric acid and incident cardiovascular–kidney–metabolic syndrome components: Outcome-specific mediating role of adiposity in a large community-based cohort

Journal of International Medical Research
Objective Serum uric acid links cardiovascular, kidney, and metabolic health; however, its role within the cardiovascular–kidney–metabolic syndrome framework is poorly understood, especially its long-term dynamics.
Xiaoqing Chen, Jianhua Gu, Ye Xu, Fang Yuan   +3 more
doaj   +1 more source

Low Cardiorespiratory Fitness is an Independent Predictor of Metabolic Syndrome in Young Korean Adults [PDF]

, 2008
Objective: To investigate the relationship between cardio/respiratory fitness (CRF) and metabolic syndrome (MS) in young Korean men. Design: In a cross-sectional study, we examined 909 young Korean men (mean±SD age, 24.0±2 years) who were ...
Hyun-Sik Kang, Soo-Hyun Park, Shinuk Kim
core  

Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis

Advanced Science, EarlyView.
A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen, Shen Zhang, Yuli Zhu, Da Zhou, Chunya Ji, Mingrui Zhu, Sirui Wang, Yuting Shen, Jifeng Yu, Heng Zhang, Yan Fang, Huixiong Xu, Haohao Yin   +12 more
wiley   +1 more source

CARDIAL-MS (CArdio-Renal-DIAbetes-Liver-Metabolic Syndrome): a new proposition for an integrated multisystem metabolic disease

Diabetology & Metabolic Syndrome
Background Metabolic Syndrome—a constellation of insulin resistance, cardiovascular risk factors as hyperglycemia, hypertension, and dyslipidemia, and systemic metabolic dysfunction—may be driven by dysregulation of adipose tissue, which manifests as ...
Amélio F. Godoy-Matos, Cynthia Melissa Valério, Wellington S. Silva Júnior, João Marcello de Araujo-Neto, Andrei C. Sposito, José Hermógenes Rocco Suassuna   +5 more
doaj   +1 more source

A holistic approach to managing cardio-kidney metabolic syndrome: insights and recommendations from the Italian perspective

Frontiers in Cardiovascular Medicine
Cardio-kidney metabolic (CKM) syndrome represents a complex and circular interplay of cardiovascular, renal, and metabolic dysfunctions, significantly contributing to global morbidity and mortality.
Massimo Iacoviello, Mauro Gori, Giuseppe Grandaliano, Giuseppe Grandaliano, Roberto Minutolo, Dario Pitocco, Roberto Trevisan, Roberto Trevisan   +7 more
doaj   +1 more source