Results 61 to 70 of about 3,282 (271)

Counselling for career construction for an artistic child with career undecidedness: implications for early child development [PDF]

International Journal of Adolescence and Youth, 2021
This article describes the influence of counselling for career construction on an artistic young girl with career undecidedness. Purposeful sampling was used to select a 14-year-old participant from young children who had sought counselling for career construction in a private practice context.
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Sustainable Career Cards Sort (SCCS): Linking Career Choices to the World Needs [PDF]

, 2019
Recently, there has been a call for career counseling interventions that promote the construction of a more humane sustainable world. In fact, contemporary world is facing collateral crises at various levels, and career counselors should be able to help ...
Shékina Rochat, Masdonati, Jonas, Jonas Masdonati, Rochat, Shékina   +3 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Research on the Effect Mechanism of Career-Specific Parental Support Promoting Meaning in Life of Chinese Higher Vocational College Students

Behavioral Sciences
Adolescent students’ meaning in life is an important topic of research in positive psychology and educational psychology. Meaning in life is of outstanding value to the whole career development of Chinese higher vocational college students (CHVCS), and ...
Huadi Wang, Jiawen Liu, Chunyu Li, Anqi Fang, Gongjing Wang   +4 more
doaj   +1 more source

高中學生生涯發展組型建構及其在升學與生涯輔導上的意義 The Construction of Career Development Patterns and Its Applications to Academic and Career Counseling

Journal of Research in Education Sciences, 2010
本研究旨在發現高中學生不同的「生涯發展組型」（career development patterns, CDP），進而對CDP 進行效度考驗，並探析其在升學及生涯輔導上的意義。本研究分三部分：一、組型建構：採取量化取向之調查法，根據20 所高中1,443 名學生在「工作價值觀量表」、「生涯探索量表」與「多元智能量表」上的評量結果，加上學科能力測驗（五科）成績，以總共三十種變項進行因素分析和典型相關分析，綜合研判組合成為八種有意義的CDP，包括實用組型、研究組型、藝術組型、社會組型、企業組型、事務組型 ...
吳武典 Wu-Tien Wu, 簡茂發 Maw-Fa Chien, 洪冬桂 Tung-Kuei Hung, 舒琮慧 zung-Huei Shu, 鄒小蘭 Hsiao-Lan Chau, 張芝萱 Chih-Hsuan Chang, 吳道愉 Tao-Yu Wu   +6 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Career construction counseling: outcome and process in case studies [PDF]

, 2020
Tese de Doutoramento em Psicologia AplicadaO Aconselhamento de Construção de Carreira visa apoiar a reconstrução da identidade narrativa para facilitar novos planos de carreira.
Silva, Filipa Raquel Fernandes da
core