Results 51 to 60 of about 3,282 (271)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Career development learning in higher education: how authentic work experiences and opportunities for career exploration canincrease self-efficacy and inform career identity [PDF]

open access: yes, 2015
A recent study suggests that enhancing career development is a key motivator for students entering university (Kandiko & Mawer, 2013). This article discusses the place of career development learning within the ‘employability’ agenda.
Benton, Paula
core  

Assessment of Staff Attitudes towards People with Disability

open access: yesSiglo Cero, 2017
The main purpose of this study was the construction and validation of a scale of attitudes towards people with disabilities, mainly directed at professionals in the areas of health and education. Participants were 976 professionals from different fields (
Víctor ARIAS GONZÁLEZ   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

APPROACHES TO CAREER GUIDANCE IN EDUCATIONAL INSTITUTIONS

open access: yesВестник Тамбовского университета. Серия: Гуманитарные науки, 2017
The career guidance in an educational institution is considered. It has been determined that the professional development of the individual begins with the moment when a person first thinks about future activities, trying to identify the range of his/her
M. A. Boldina, E. V. Deeva
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Techniques in career construction counseling [PDF]

open access: yes, 2013
The use of career construction theory is becoming a prominent fixture in the landscape of he new career paradigm. Flexibility, adaptability, and self-constructed career stories are the focus of career counseling in the 21st century.
Stoltz, Kevin B.
core  

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

Women and Careers: New Zealand Women's Engagement in Career and Family Planning [PDF]

open access: yes, 2015
This study investigated the extent women engage in career planning, and whether making considerations to have children would influence their career plans.
Ussher, Sarah Rosemary
core  

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