Results 81 to 90 of about 672,324 (310)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Career writing interventions for career learning

British Journal of Guidance and Counselling
This integrative literature review aimed to synthesise published research on the use of expressive, reflective and creative writing in a career context, known as Career Writing. Studies included English-language research from peer-reviewed journals published between 1990 and 2020 with intervention(s) involving writing for personal and professional ...
McNichol, Angela Kathleen, Lengelle, Reinekke, Poell, Robert Frans   +2 more
openaire   +2 more sources

Self career management: effectiveness of an intervention process [PDF]

, 2009
Since the 20th century, careers have undergone crucial changes (Arthur & Rouseau, 1996; Parker & Inkson, 1999; Thite, 2001), becoming increasingly “boundaryless” and “protean” (e.g., Arthur & Rousseau, 1996; Hall, 1996; Seibert, Kraimer, & Crant, 2001 ...
Pinto, Joana Carneiro, Taveira, Maria do Céu   +1 more
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Career self-management : evaluation of an intervention with culturally diverse samples [PDF]

, 2011
“Career Self-Management Seminar”, in its version B, (CSMS-B, [1]), is a specialized psychological intervention model designed to support academics in career exploration, goal setting, design and implementation of action plans, and monitoring and feedback
Pinto, Joana Carneiro, Silva, Ana Daniela, Taveira, Maria do Céu   +2 more
core  

Computer Programming Effects in Elementary: Perceptions and Career Aspirations in STEM

, 2018
The development of elementary-aged students’ STEM and computer science (CS) literacy is critical in this evolving technological landscape, thus, promoting success for college, career, and STEM/CS professional paths. Research has suggested that elementary-
Tran, Yune
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Life-design counselling for survivors of family violence in resource-constrained areas

South African Journal of Education, 2020
The purpose of this study was to explore and assess the feasibility of counselling based on life-design principles in enhancing the career resilience of children who are exposed to family violence. The research project involved a QUALITATIVE–quantitative
Cobus J. Venter , Jacobus G. Maree
doaj   +1 more source

A systematic review of strategies to recruit and retain primary care doctors [PDF]

, 2016
Background There is a workforce crisis in primary care. Previous research has looked at the reasons underlying recruitment and retention problems, but little research has looked at what works to improve recruitment and retention.
A Douglas, Amanda Howe, Arabella Stuart, B Beaumont, BJ Crouse, C Dolea, CD White, CG Morris, D Wilkinson, DE Pathman, DE Pathman, DM Barclay 3rd, DM Charles, DR Wilson, F Eskin, G Freeman, GW Halaas, H Felix, HK Rabinowitz, J Harrison, J Jackson, J Smucny, JA Stearns, JH Magnus, John A. Ford, JS Dunbabin, K Straume, K Straume, KJ Quinn, L Bellman, L Delacourt, L Lockyer, M Anderson, M Baker, M Gardiner, M James, M Landry, M Mathews, M Mathews, M Matsumoto, M Matsumoto, M Robinson, M Viscomi, N Abbt, N Nichols, Nicholas Steel, P Czapski, P Green, P MacIsaac, Puja Verma, R Bregazzi, R Petchey, RJ Adkins, S Hilton, S Pena, S Wearne, Sam Everington, The Future Primary Care Workforce : creating teams for tomorrow, TJ Cullen, TR Kahn   +59 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source