Results 61 to 70 of about 1,411,437 (357)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Three Strategies for Managing through Economic Change [PDF]

, 2010
[Excerpt] Since its implementation, strategic human resource management has helped assuage the age-old conflict formerly accepted to be inherent between employees and management. The interests of these two parties have long been erroneously assumed to be
Sherman, John
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CAREER MANAGEMENT IN THE MINISTRY FOR ADMINISTRATIVE REFORM AND THE BUREAUCRATIC STATE APPARATUS [PDF]

, 2016
Career management is one part discussion of human resources management. Human resources reform is a crucial element for the effectiveness of the performance of the bureaucracy.
Irawan, Irawan, Kismartini, Kismartini, Suwitri, Sri, Warella, Y   +3 more
core  

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Association between resilience, perfectionism and job satisfaction among medical residents in Croatia: a cross-sectional study

BMC Psychology
Background Medical residents are among the most vulnerable healthcare workers making their job satisfaction a critical factor influencing mental health, quality of care, and retention.
Antonia Peroš, Ivan Buljan
doaj   +1 more source

The role of psychological factors in the career of the independent dancer [PDF]

, 2015
Previous research indicates that psychological factors such as motivation and mental skills play an important role in relation to performance and to negotiating talent development stages.
Abbott, Alfermann, Alter, Aujla, Aujla, Clark, Clarke, Clarke, Creswell, Critien, Deci, Deci, Dodge, Gould, Gould, Hanrahan, Kogan, Krasnow, Krauss, Kreiner-Phillips, Kvale, MacNamara, MacNamara, MacNamara, MacNamara, Mallett, Maslow, Morris, Nieminen, Noh, Nordin, Nordin, Nordin, Orlick, Patton, Quested, Rouhiainen, Ryan, Ryff, Scheier, Seligman, Shah, Sparkes, Stambulova, Stinson, Talbot-Honeck, Vealey, Wainwright, Walker, Waterman   +49 more
core   +3 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Career Management

, 2019
The details fulfilled with about career management. The process involved in management and essentials of career planning bring out the skills and be adjust with others in the organization. A clear view of mapping, path interventions, and also situations in public organization well goes then career growth with career development.
openaire   +1 more source