Results 61 to 70 of about 9,220 (223)

Penetration enhancement effects of topically applied crosslinked hyaluronic acid

International Journal of Cosmetic Science, EarlyView.
Cross‐linked hyaluronic acid (HA) was demonstrated to enhance the topical delivery of a variety of hydrophilic actives into the skin. This phenomenon was observed for both small molecules and macromolecules, the latter of which was analysed with MALDI mass spectrometry imaging (MALDI‐MSI).
Aaron Cohen, Raphael Legouffe, Krystal House, Paul Duhamel, Aurore Tomezyk, Mathieu Gaudin, Junhong Mao, David Bonnel   +7 more
wiley   +1 more source

Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity

Frontiers in Pharmacology
Oral consumption of histidyl dipeptides such as l-carnosine has been suggested to promote cardiometabolic health, although therapeutic mechanisms remain incompletely understood.
Islam A. Berdaweel, Islam A. Berdaweel, T. Blake Monroe, Amany A. Alowaisi, Amany A. Alowaisi, Jolonda C. Mahoney, I-Chau Liang, Kaitlyn A. Berns, Dylan Gao, Jared M. McLendon, Jared M. McLendon, Ethan J. Anderson, Ethan J. Anderson, Ethan J. Anderson   +13 more
doaj   +1 more source

Carnosine Inhibits the Proliferation of Human Cervical Gland Carcinoma Cells Through Inhibiting Both Mitochondrial Bioenergetics and Glycolysis Pathways and Retarding Cell Cycle Progression

Integrative Cancer Therapies, 2018
Carnosine has been demonstrated to play an antitumorigenic role in certain types of cancer. However, its underlying mechanism is unclear. In this study, the roles of carnosine in cell proliferation and its underlying mechanism were investigated in the ...
Yun Bao MS, Saidan Ding PhD, Jiaoyan Cheng BS, Yuan Liu BS, Bingyu Wang BS, Huijuan Xu BS, Yao Shen PhD, Jianxin Lyu PhD   +7 more
doaj   +1 more source

Virocell Necromass Provides Limited Plant Nitrogen and Elicits Rhizosphere Metabolites That Affect Phage Dynamics

Plant, Cell &Environment, EarlyView.
ABSTRACT Bacteriophages impact soil bacteria through lysis, altering the availability of organic carbon and plant nutrients. However, the magnitude of nutrient uptake by plants from lysed bacteria remains unknown, partly because this process is challenging to investigate in the field.
Vlastimil Novak, Michelle C. M. van Winden, Thomas V. Harwood, Rachel Neurath, Suzanne M. Kosina, Katherine B. Louie, Matthew B. Sullivan, Simon Roux, Karsten Zengler, Vivek K. Mutalik, Trent R. Northen   +10 more
wiley   +1 more source

Carnosine Activates Cellular Stress Response in Podocytes and Reduces Glycative and Lipoperoxidative Stress

Biomedicines, 2020
Carnosine improves diabetic complications, including diabetic nephropathy, in in vivo models. To further understand the underlying mechanism of nephroprotection, we studied the effect of carnosine under glucose-induced stress on cellular stress response ...
Maria Scuto, Angela Trovato Salinaro, Sergio Modafferi, Alessandra Polimeni, Tilman Pfeffer, Tim Weigand, Vittorio Calabrese, Claus Peter Schmitt, Verena Peters   +8 more
doaj   +1 more source

Prevention of Atopic Dermatitis in High‐Risk Infants: A Review of the Role of Lipid‐Based Barrier Repair Therapy

Pediatric Dermatology, EarlyView.
ABSTRACT Background/Objective Growing evidence highlights the role of physiological lipids, namely ceramides, cholesterol, and free fatty acids, in maintaining skin barrier function and preventing atopic dermatitis (AD). Current evidence on the efficacy, safety, and clinical relevance of stratum corneum (SC) lipid‐based therapies to prevent AD and ...
Chon‐Wai Jeremy Chan, Marty O. Visscher   +1 more
wiley   +1 more source

Anti-Cancer Effects of Carnosine—A Dipeptide Molecule

Molecules, 2021
Background: Carnosine is a dipeptide molecule (β-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It is used in exercise physiology as a food supplement to increase performance; however, in vitro evidence
Monica D. Prakash, Sarah Fraser, Jennifer C. Boer, Magdalena Plebanski, Barbora de Courten, Vasso Apostolopoulos   +5 more
doaj   +1 more source

Quantification of Tryptophan and NAD+ Proton Magnetization Exchange With Water Using Downfield 1H MRS in the Human Brain at 7 T

Magnetic Resonance in Medicine, Volume 95, Issue 3, Page 1336-1344, March 2026.
ABSTRACT Purpose The purpose of this study was to investigate the effect of magnetization exchange on the measurement of tryptophan and NAD+ T1 relaxation times and to determine the magnetization exchange rates with a two‐spin system model using downfield 1H MRS spectroscopy at 7 T in human brain.
Sophia Swago, Neil E. Wilson, Mark A. Elliott, Ravinder Reddy, Walter R. Witschey, Ravi Prakash Reddy Nanga   +5 more
wiley   +1 more source

Characterization of Bromelain‐Soluble Sheepskin (Ovis aries) Proteins and Effect of In Vitro Gastrointestinal Digestion on Angiotensin Converting Enzyme Inhibition Activity

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Novel bioactive peptides resulted from in vitro gastrointestinal digestion of soluble sheep skin protein. ABSTRACT This work characterizes proteins extracted from sheepskin using bromelain and examines angiotensin converting enzyme (ACE) inhibition activity of the peptides generated by in vitro gastrointestinal digestion (GID).
Dita Prameswari Trenggono Putri, Marta Gallego, Mohammad Zainal Abidin, Nanung Agus Fitriyanto, Leticia Mora, Fidel Toldrá, Yuny Erwanto   +6 more
wiley   +1 more source

Evaluation of the Transepidermal Penetration of a Carnosine Complex in Gel Formulation by 3D Skin Models

Cosmetics, 2018
Carnosine has several physiological roles, from intracellular pH buffering to antioxidant activities, which all depend on bioavailability. This study was conducted in a human skin 3D model and focuses on the effects of the topical delivery of carnosine ...
Valeria Dissette, Carlo Alberto Bignozzi, Giuseppe Valacchi, Alessandra Pecorelli, Stefano Manfredini, Silvia Vertuani   +5 more
doaj   +1 more source