Results 71 to 80 of about 22,312 (304)

Genetic Polymorphisms of Carnosine Synthase -1(ATPGD1) and Serum Carnosine Levels in Relation to Cardiovascular Diseases in Iraqi Type 2 Diabetics

Iraqi Journal of Pharmaceutical Sciences
Diabetes mellitus (DM) is a metabolic disorder specified by persistent hyperglycemia that occurs when β-cell insulin production became unable to control blood glucose with deterioration of response for insulin.
Haneen Subhee Shaheed, Shatha H Ali
doaj   +1 more source

Investigation of Dose-Related Effects of Carnosine on Anxiety with Sympathetic Skin Response and T-maze

Acta Medica, 2014
Carnosine is a dipeptide formed of the amino acids β-alanine and histidine. Only a limited number of studies have examined the effects of carnosine on sympathetic nerve activation and anxiety.
Nazan Dolu, Hale Acer, Ali Yucel Kara
doaj   +1 more source

Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke [PDF]

, 2016
Carnosine is a naturally occurring pleotropic dipeptide which influences multiple deleterious mechanisms that are activated during stroke. Numerous published studies have reported that carnosine has robust efficacy in ischemic stroke models. To further
Bahor, Z., Davis, C.K., Laud, P.J., Majid, A., Rajanikant, G.K.   +4 more
core   +1 more source

Exercise training and beta-alanine-induced muscle carnosine loading [PDF]

, 2015
PURPOSE: Beta-alanine (BA) supplementation has been shown to augment muscle carnosine concentration, thereby promoting high-intensity (HI) exercise performance.
Achten, Eric, Baguet, Audrey, Bex, Tine, Chung, Weiliang, Derave, Wim   +4 more
core   +3 more sources

Evaluation of supplementary carnosine accumulation and distribution: an initial analysis of participants in the Nucleophilic Defense Against PM Toxicity (NEAT) clinical trial

Amino Acids
Carnosine is an endogenous dipeptide that buffers intracellular pH and quenches toxic products of lipid peroxidation. Used as a dietary supplement, it also supports exercise endurance.
Shahid P. Baba, Alok R. Amraotkar, David Hoetker, Hong Gao, Daniel Gomes, Jingjing Zhao, Michael F. Wempe, Peter J. Rice, Andrew P. DeFilippis, Shesh N. Rai, C. Arden Pope, Aruni Bhatnagar, Timothy E. O’Toole   +12 more
doaj   +1 more source

Expression profiles of carnosine synthesis–related genes in mice after ingestion of carnosine or ß-alanine

Journal of the International Society of Sports Nutrition, 2012
Background Carnosine is a dipeptide that improves exercise performance. The carnosine synthesis mechanism through carnosine and ß-alanine ingestion remains unclear.
Miyaji Takayuki, Sato Mikako, Maemura Hirohiko, Takahata Yoshihisa, Morimatsu Fumiki   +4 more
doaj   +1 more source

Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis

Oncology Letters, 2021
Carnosine (β-alanyl-L-histidine) is found in beef and fish. The present study aimed to investigate the effects of carnosine on the cell proliferation of human colorectal cancer cells. After human colorectal cancer HCT-116 cells were treated carnosine for
S. Hsieh, Jia-Huei Li, C. Dong, Chiu-wen Chen, Chih-Chung Wu   +4 more
semanticscholar   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

PEGylation renders carnosine resistant to hydrolysis by serum carnosinase and increases renal carnosine levels

Amino Acids
Carnosine’s protective effect in rodent models of glycoxidative stress have provided a rational for translation of these findings in therapeutic concepts in patient with diabetic kidney disease.
Shiqi Zhang, Guang Yang, Qinqin Zhang, Yuying Fan, Mingna Tang, Liuhai Shen, Dongchun Zhu, Guiyang Zhang, Benito Yard   +8 more
doaj   +1 more source

The effect of rearing system and cooking method on the carnosine and anserine content of poultry and game meat [PDF]

, 2018
Poultry meat has been shown to be a rich source of carnosine and anserine (CRC) but little is known of the effects of bird species and the system under which it is reared have on the concentrations of CRC. Retail samples of breast meat from conventional
Juniper, Darren, Rymer, Caroline
core   +2 more sources