Results 1 to 10 of about 6,837,473 (418)
Structure, function and dynamics in acyl carrier proteins. [PDF]
PLoS ONE, 2019 Carrier proteins are four-helix bundles that covalently hold metabolites and secondary metabolites, such as fatty acids, polyketides and non-ribosomal peptides.
Rohit Farmer +2 more
doaj +3 more sources
Journal of Biological Chemistry, 1969 Abstract Holo acyl carrier protein synthetase transfers 4'-phosphopantetheine from reduced coenzyme A to acyl carrier protein (ACP) apoprotein to form ACP holoprotein (holo-ACP). The specificity of this enzyme was tested by using apopeptides derived from ACP. The apopeptides were derived from holopeptides, those containing 4'-phosphopantetheine, by the
P R Vagelos +2 more
+8 more sources
A guide to plasma membrane solute carrier proteins. [PDF]
FEBS J, 2021 This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 families that carry a wide variety ...
Pizzagalli MD +2 more
europepmc +2 more sources
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway. [PDF]
Life Sci Alliance, 2021 The GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.
Xiao T, Shakya VP, Hughes AL.
europepmc +2 more sources
Moco Carrier and Binding Proteins
Molecules, 2022 The molybdenum cofactor (Moco) is the active site prosthetic group found in numerous vitally important enzymes (Mo-enzymes), which predominantly catalyze 2 electron transfer reactions. Moco is synthesized by an evolutionary old and highly conserved multi-
Tobias Kruse
doaj +4 more sources
Carrier Proteins Facilitate the Generation of Antipolysaccharide Immunity via Multiple Mechanisms [PDF]
mBio, 2022 Capsular polysaccharides (CPSs) are important antigenic targets against bacterial infections. As T-independent antigens, however, CPSs elicit short-lived immune responses in adults and are poorly immunogenic in young children.
Fan Zhang +4 more
doaj +2 more sources
Transport of Proteins into Mitochondria [PDF]
, 1980 The mitochondrial ADP/ATP carrier is an integral transmembrane protein of the inner membrane. It is synthesized on cytoplasmic ribosomes. Kinetic data suggested that this protein is transferred into mitochondria in a posttranslational manner.
Allen E. H. +41 more
core +3 more sources
Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins. [PDF]
Mol Pharm, 2018 Vaccines may offer a new treatment strategy for opioid use disorders and opioid-related overdoses. To speed translation, this study evaluates opioid conjugate vaccines containing components suitable for pharmaceutical manufacturing and compares ...
Baruffaldi F +10 more
europepmc +2 more sources
Regulation of zinc-dependent enzymes by metal carrier proteins. [PDF]
Biometals, 2022 Thompson MW.
europepmc +2 more sources
Journal of Biological Chemistry, 1972 β-Ketoacyl-acyl carrier protein (ACP) synthetase catalyzes the chain elongation step of fatty acid biosynthesis, the condensation of fatty acyl-ACP with malonyl-ACP yielding β-ketoacyl-ACP, CO2, and ACP. This enzyme catalyzes two additional reactions, fatty acyl-CoA-ACP transacylation and the decarboxylation of malonyl-ACP to form acetyl-ACP and CO2 ...
Alfred W. Alberts +2 more
+7 more sources