ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway [PDF]
Life Science Alliance, 2021 The GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.
Tianyao Xiao +2 more
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Moco Carrier and Binding Proteins
Molecules, 2022 The molybdenum cofactor (Moco) is the active site prosthetic group found in numerous vitally important enzymes (Mo-enzymes), which predominantly catalyze 2 electron transfer reactions. Moco is synthesized by an evolutionary old and highly conserved multi-
Tobias Kruse
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Carrier Proteins Facilitate the Generation of Antipolysaccharide Immunity via Multiple Mechanisms [PDF]
mBio, 2022 Capsular polysaccharides (CPSs) are important antigenic targets against bacterial infections. As T-independent antigens, however, CPSs elicit short-lived immune responses in adults and are poorly immunogenic in young children.
Fan Zhang +4 more
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Structure, function and dynamics in acyl carrier proteins. [PDF]
PLoS ONE, 2019 Carrier proteins are four-helix bundles that covalently hold metabolites and secondary metabolites, such as fatty acids, polyketides and non-ribosomal peptides.
Rohit Farmer +2 more
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Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis [PDF]
FEBS Open Bio, 2016 Phosphopantetheinyl transferases (PPTases) are key elements in the modular syntheses performed by multienzyme systems such as polyketide synthases.
James Jung +3 more
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Predicting substrates for orphan solute carrier proteins using multi-omics datasets [PDF]
BMC GenomicsSolute carriers (SLC) are integral membrane proteins responsible for transporting a wide variety of metabolites, signaling molecules and drugs across cellular membranes. Despite key roles in metabolism, signaling and pharmacology, around one third of SLC
Y. Zhang, S. Newstead, P. Sarkies
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Presentation matters: Impact of association of amphiphilic LPS with serum carrier proteins on innate immune signaling. [PDF]
PLoS ONE, 2018 Recognition of Pathogen-associated Molecular Patterns (PAMPs) by Toll-like receptors is central to innate immunity. Many bacterial PAMPs such as lipopolysaccharide (LPS) and lipoteichoic acid have amphiphilic properties. The hydrophobicity of amphiphilic
Loreen R Stromberg +5 more
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Carriers and Antigens: New Developments in Glycoconjugate Vaccines
Vaccines, 2023 Glycoconjugate vaccines have proven their worth in the protection and prevention of infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the prime example, followed by other glycoconjugate vaccines.
Robert M.F. van der Put +2 more
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Pathophysiology of sepsis‐induced cholestasis: A review
JGH Open, 2022 Sepsis is a critical condition resulting from the excessive activation of the inflammatory/immune system in response to an infection, with high mortality if treatment is not administered promptly. One of the many possible complications of sepsis is liver
Maria Iuliana Ghenu +4 more
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Toxics, 2022 Tobacco/nicotine is one of the most toxic and addictive substances and continues to pose a significant threat to global public health. The harmful effects of smoking/nicotine affect every system in the human body.
Mohd Rehan +6 more
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