Structure, function and dynamics in acyl carrier proteins. [PDF]
PLoS ONE, 2019 Carrier proteins are four-helix bundles that covalently hold metabolites and secondary metabolites, such as fatty acids, polyketides and non-ribosomal peptides.
Rohit Farmer +2 more
doaj +3 more sources
Regulation of zinc-dependent enzymes by metal carrier proteins. [PDF]
Biometals, 2022 Zn2+ ions are essential in many physiological processes, including enzyme catalysis, protein structural stabilization, and the regulation of many proteins.
Thompson MW.
europepmc +2 more sources
A guide to plasma membrane solute carrier proteins. [PDF]
FEBS J, 2021 This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 families that carry a wide variety ...
Pizzagalli MD +2 more
europepmc +2 more sources
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway. [PDF]
Life Sci Alliance, 2021 The GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.
Xiao T, Shakya VP, Hughes AL.
europepmc +2 more sources
Carrier Proteins Facilitate the Generation of Antipolysaccharide Immunity via Multiple Mechanisms [PDF]
mBio, 2022 Capsular polysaccharides (CPSs) are important antigenic targets against bacterial infections. As T-independent antigens, however, CPSs elicit short-lived immune responses in adults and are poorly immunogenic in young children.
Fan Zhang +4 more
doaj +2 more sources
Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins. [PDF]
Mol Pharm, 2018 Vaccines may offer a new treatment strategy for opioid use disorders and opioid-related overdoses. To speed translation, this study evaluates opioid conjugate vaccines containing components suitable for pharmaceutical manufacturing and compares ...
Baruffaldi F +10 more
europepmc +2 more sources
Transport of Proteins into Mitochondria [PDF]
, 1980 The mitochondrial ADP/ATP carrier is an integral transmembrane protein of the inner membrane. It is synthesized on cytoplasmic ribosomes. Kinetic data suggested that this protein is transferred into mitochondria in a posttranslational manner.
Allen E. H. +41 more
core +3 more sources
Predicting substrates for orphan solute carrier proteins using multi-omics datasets [PDF]
BMC GenomicsSolute carriers (SLC) are integral membrane proteins responsible for transporting a wide variety of metabolites, signaling molecules and drugs across cellular membranes. Despite key roles in metabolism, signaling and pharmacology, around one third of SLC
Y. Zhang, S. Newstead, P. Sarkies
doaj +2 more sources
Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis [PDF]
FEBS Open Bio, 2016 Phosphopantetheinyl transferases (PPTases) are key elements in the modular syntheses performed by multienzyme systems such as polyketide synthases.
James Jung +3 more
doaj +2 more sources
New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis. [PDF]
Angew Chem Int Ed Engl, 2016 The nonribosomal peptide synthetases (NRPSs) are one of the most promising resources for the production of new bioactive molecules. The mechanism of NRPS catalysis is based around sequential catalytic domains: these are organized into modules, where each
Kittilä T +3 more
europepmc +2 more sources