Results 1 to 10 of about 312,617 (308)
Journal of Biological Chemistry, 1969 Abstract Holo acyl carrier protein synthetase transfers 4'-phosphopantetheine from reduced coenzyme A to acyl carrier protein (ACP) apoprotein to form ACP holoprotein (holo-ACP). The specificity of this enzyme was tested by using apopeptides derived from ACP. The apopeptides were derived from holopeptides, those containing 4'-phosphopantetheine, by the
Michael D. Greenspan +2 more
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Moco Carrier and Binding Proteins
Molecules, 2022 The molybdenum cofactor (Moco) is the active site prosthetic group found in numerous vitally important enzymes (Mo-enzymes), which predominantly catalyze 2 electron transfer reactions. Moco is synthesized by an evolutionary old and highly conserved multi-
Tobias Kruse
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Carrier Proteins Facilitate the Generation of Antipolysaccharide Immunity via Multiple Mechanisms [PDF]
mBio, 2022 Capsular polysaccharides (CPSs) are important antigenic targets against bacterial infections. As T-independent antigens, however, CPSs elicit short-lived immune responses in adults and are poorly immunogenic in young children.
Fan Zhang +4 more
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Journal of Biological Chemistry, 1972 β-Ketoacyl-acyl carrier protein (ACP) synthetase catalyzes the chain elongation step of fatty acid biosynthesis, the condensation of fatty acyl-ACP with malonyl-ACP yielding β-ketoacyl-ACP, CO2, and ACP. This enzyme catalyzes two additional reactions, fatty acyl-CoA-ACP transacylation and the decarboxylation of malonyl-ACP to form acetyl-ACP and CO2 ...
Claire H. Birge, P. Roy Vagelos
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Structure, function and dynamics in acyl carrier proteins. [PDF]
PLoS ONE, 2019 Carrier proteins are four-helix bundles that covalently hold metabolites and secondary metabolites, such as fatty acids, polyketides and non-ribosomal peptides.
Rohit Farmer +2 more
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Predicting substrates for orphan solute carrier proteins using multi-omics datasets [PDF]
BMC GenomicsSolute carriers (SLC) are integral membrane proteins responsible for transporting a wide variety of metabolites, signaling molecules and drugs across cellular membranes. Despite key roles in metabolism, signaling and pharmacology, around one third of SLC
Y. Zhang, S. Newstead, P. Sarkies
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Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis [PDF]
FEBS Open Bio, 2016 Phosphopantetheinyl transferases (PPTases) are key elements in the modular syntheses performed by multienzyme systems such as polyketide synthases.
James Jung +3 more
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Presentation matters: Impact of association of amphiphilic LPS with serum carrier proteins on innate immune signaling. [PDF]
PLoS ONE, 2018 Recognition of Pathogen-associated Molecular Patterns (PAMPs) by Toll-like receptors is central to innate immunity. Many bacterial PAMPs such as lipopolysaccharide (LPS) and lipoteichoic acid have amphiphilic properties. The hydrophobicity of amphiphilic
Loreen R Stromberg +5 more
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Carriers and Antigens: New Developments in Glycoconjugate Vaccines
Vaccines, 2023 Glycoconjugate vaccines have proven their worth in the protection and prevention of infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the prime example, followed by other glycoconjugate vaccines.
Robert M.F. van der Put +2 more
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EXPRESSION AND SIGNIFICANCE OF SECRETORY CARRIER MEMBRANE PROTEIN 2 IN COLORECTAL CANCER [PDF]
精准医学杂志, 2023 Objective To investigate the expression and significance of secretory carrier membrane protein 2 (SCAMP2) in colorectal cancer (CRC). Methods Paraffin tissue samples and clinicopathological data were collected from 309 patients with primary CRC who were ...
QIAO Yehua, GUO Dong, WANG Lu, QU Tingting, ZHANG Xiangyan, XING Xiaoming
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