Results 31 to 40 of about 560,339 (380)

The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments

BMC Biology, 2020
Background The mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial membrane.
Heike Rampelt, Iva Sucec, Beate Bersch, Patrick Horten, Inge Perschil, Jean-Claude Martinou, Martin van der Laan, Nils Wiedemann, Paul Schanda, Nikolaus Pfanner   +9 more
doaj   +1 more source

Biogenesis of Mitochondrial Metabolite Carriers

Biomolecules, 2020
Metabolite carriers of the mitochondrial inner membrane are crucial for cellular physiology since mitochondria contribute essential metabolic reactions and synthesize the majority of the cellular ATP. Like almost all mitochondrial proteins, carriers have
Patrick Horten, Lilia Colina-Tenorio, Heike Rampelt   +2 more
doaj   +1 more source

Structural informatic study of determined and AlphaFold2 predicted molecular structures of 13 human solute carrier transporters and their water-soluble QTY variants

Scientific Reports, 2022
Solute carrier transporters are integral membrane proteins, and are important for diverse cellular nutrient transports, metabolism, energy demand, and other vital biological activities.
Eva Smorodina, Igor Diankin, Fei Tao, Rui Qing, Steve Yang, Shuguang Zhang   +5 more
doaj   +1 more source

Different Transport Pathways of Individual Precursor Proteins in Mitochondria [PDF]

, 1981
Transport of mitochondrial precursor proteins into mitochondria of Neurospora crassa was studied in a cellfree reconstituted system. Precursors were synthesized in a reticulocyte lysate programmed with Neurospora mRNA and transported into isolated ...
Allen E. H., Ambler R. P., Basile G., Conboy J. G., Cote C., Fisher W. R., Hackenberg H., Hallermayer G., Harmey M. A., Heller J., Jagow G., Korb H., Laemmli U. K., Lewin A., Maccechini M. -L., Maccechini M. -L., Michel R., Mihara K., Mori M., Nelson N, Paul K. G., Pelham H. R. B., Raymond Y., Schatz G., Schmelzer E., Sebald W., Shore G. S., Sonderegger P., Tzagoloff A., Zimmermann R., Zimmermann R., Zimmermann R.   +31 more
core   +1 more source

Vegetable proteins in microencapsulation: a review of recent interventions and their effectiveness [PDF]

, 2013
Proteins from vegetable seeds are interesting for research at present because they are an abundant alternative to animal-based sources of proteins and petroleum-derived polymers.
Alric, Isabelle, Durrieu, Vanessa, Nesterenko, Alla, Silvestre, Françoise   +3 more
core   +1 more source

Engineering an AB5 Protein Carrier [PDF]

Scientific Reports, 2018
AbstractThe promise of biologic therapeutics is hindered by the challenge to deliver their activity to biochemically relevant sites within diseased cells. The favourable application of the natural protein carriers of the AB5 toxin family to this challenge has been restricted owing to still unresolved requirements for assembling non-native cargo into ...
Birte Höcker, Birte Höcker, Bruce R. Lichtenstein   +2 more
openaire   +4 more sources

Random and combinatorial mutagenesis for improved total production of secretory target protein in Escherichia coli

Scientific Reports, 2021
Signal peptides and secretory carrier proteins are commonly used to secrete heterologous recombinant protein in Gram-negative bacteria. The Escherichia coli osmotically-inducible protein Y (OsmY) is a carrier protein that secretes a target protein ...
David Gonzalez-Perez, James Ratcliffe, Shu Khan Tan, Mary Chen May Wong, Yi Pei Yee, Natsai Nyabadza, Jian-He Xu, Tuck Seng Wong, Kang Lan Tee   +8 more
doaj   +1 more source

Presentation matters: Impact of association of amphiphilic LPS with serum carrier proteins on innate immune signaling. [PDF]

PLoS One, 2018
Recognition of Pathogen-associated Molecular Patterns (PAMPs) by Toll-like receptors is central to innate immunity. Many bacterial PAMPs such as lipopolysaccharide (LPS) and lipoteichoic acid have amphiphilic properties. The hydrophobicity of amphiphilic
Stromberg LR, Mendez HM, Kubicek-Sutherland JZ, Graves SW, Hengartner NW, Mukundan H.   +5 more
europepmc   +2 more sources

Lipid carrier proteins and ethanol

Journal of Biomedical Science, 2001
Ethanol has a pronounced effect on lipid homeostasis. It is our overall hypothesis that certain lipid carrier proteins are targets of acute and chronic ethanol exposure and that perturbation of these proteins induces lipid dysfunction leading to cellular pathophysiology. These proteins include both intracellular proteins and lipoproteins.
Nicolai A. Avdulov, Nicolai A. Avdulov, W. Gibson Wood, W. Gibson Wood, Svetlana V. Chochina, Svetlana V. Chochina, Urule Igbavboa, Urule Igbavboa   +7 more
openaire   +3 more sources

Trapping of the Enoyl-Acyl Carrier Protein Reductase–Acyl Carrier Protein Interaction [PDF]

Journal of the American Chemical Society, 2016
An ideal target for metabolic engineering, fatty acid biosynthesis remains poorly understood on a molecular level. These carrier protein-dependent pathways require fundamental protein-protein interactions to guide reactivity and processivity, and their control has become one of the major hurdles in successfully adapting these biological machines.
Tallorin, Lorillee, Finzel, Kara, Nguyen, Quynh G, Beld, Joris, La Clair, James J, Burkart, Michael D   +5 more
openaire   +5 more sources