Results 31 to 40 of about 39,628 (288)
Structure, function and dynamics in acyl carrier proteins.
PLoS ONE, 2019 Carrier proteins are four-helix bundles that covalently hold metabolites and secondary metabolites, such as fatty acids, polyketides and non-ribosomal peptides.
Rohit Farmer +2 more
doaj +1 more source
Carrier Proteins Facilitate the Generation of Antipolysaccharide Immunity via Multiple Mechanisms
mBio, 2022 Capsular polysaccharides (CPSs) are important antigenic targets against bacterial infections. As T-independent antigens, however, CPSs elicit short-lived immune responses in adults and are poorly immunogenic in young children.
Fan Zhang +4 more
doaj +1 more source
Synthesis of Length-Tunable DNA Carriers for Nanopore Sensing [PDF]
arXiv, 2023 Molecular carriers represent an increasingly common strategy in the field of nanopore sensing to use secondary molecules to selectively report on the presence of target analytes in solution, allowing for sensitive assays of otherwise hard-to-detect molecules such as small, weakly-charged proteins.
arxiv
Manipulation of Carrier Proteins in Antibiotic Biosynthesis [PDF]
Chemistry & Biology, 2004 Engineering biosynthetic pathways into suitable host organisms has become an attractive venue for the design, evaluation, and production of small molecule therapeutics. Polyketide (PK) and nonribosomal peptide (NRP) synthases have been of particular interest due to their modular structure, yet routine cloning and expression of these enzymes remains ...
Timothy L. Foley +4 more
openaire +3 more sources
Molecular Plant-Microbe Interactions, 2022 In Xanthomonas spp., the biosynthesis of the yellow pigment xanthomonadin and fatty acids originates in the type II polyketide synthase (PKS II) and fatty acid synthase (FAS) pathways, respectively. The acyl carrier protein (ACP) is the central component
Yi-Cai Chen +8 more
doaj +1 more source
Charge transport in purple membrane monolayers: A sequential tunneling approach [PDF]
Physical Review E, 83, 042902 (2011), 2011 Current voltage (I-V) characteristics in proteins can be sensitive to conformational change induced by an external stimulus (photon, odour, etc.). This sensitivity can be used in medical and industrial applications besides shedding new light in the microscopic structure of biological materials. Here, we show that a sequential tunneling model of carrier
arxiv +1 more source
Subcellular localization of the mosquito sterol carrier protein-2 and sterol carrier protein-x [PDF]
Journal of Lipid Research, 2004 Subcellular distribution of Aedes aegypti sterol carrier protein-2 (AeSCP-2) and AeSCP-x was studied using electron microscopy. In both cultured A. aegypti cells and in the larval midgut, AeSCP-2 was detected mostly in the cytosol, with some labeling mitochondria and nucleus, but not in membranous vesicles. The widespread distribution of AeSCP-2 in the
Randall J. Massey, Que Lan
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Vaccines, 2023 Parkinson’s disease (PD) is a chronic neurodegenerative disease that affects the central nervous system, specifically the motor system. It is mainly caused by the loss of dopamine due to the accumulation of α-synuclein (α-syn) protein in the striatum and
Jun Sung Park +5 more
doaj +1 more source
Hydroxyethyl cellulose matrix applied to serial crystallography
Scientific Reports, 2017 Serial femtosecond crystallography (SFX) allows structures of proteins to be determined at room temperature with minimal radiation damage. A highly viscous matrix acts as a crystal carrier for serial sample loading at a low flow rate that enables the ...
Michihiro Sugahara +18 more
doaj +1 more source
Acyl Carrier Protein Cyanylation Delivers a Ketoacyl Synthase–Carrier Protein Cross-Link [PDF]
Biochemistry, 2017 Acyl carrier proteins (ACPs) are central hubs in polyketide and fatty acid biosynthetic pathways, but the fast motions of the ACP's phosphopantetheine (Ppant) arm make its conformational dynamics difficult to capture using traditional spectroscopic approaches.
Grace A. R. Thiele +5 more
openaire +3 more sources