Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery [PDF]
, 2019 Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used
Akk, Antonina +7 more
core +3 more sources
Enhanced Tissue Integration During Cartilage RepairIn VitroCan Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge [PDF]
, 2009 Objective: Experimental wounding of articular cartilage results in cell death at the lesion edge. The objective of this study was to investigate whether inhibition of this cell death results in enhanced integrative cartilage repair.
Archer, Charles W. +7 more
core +1 more source
Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair
Inflammation and Regeneration, 2018 Articular cartilage has poor capacity for repair. Once damaged, they degenerate, causing functional impairment of joints. Allogeneic cartilage transplantation has been performed for functional recovery of articular cartilage.
Kaoru Yamagata +2 more
doaj +1 more source
THE PERMEABILITY OF ARTICULAR CARTILAGE [PDF]
The Journal of Bone and Joint Surgery. British volume, 1968 1. We have shown that the permeability of cartilage is the same in necropsy specimens as in the living animal. We have concluded that studies of material transport into cartilage carried out on necropsy specimens validly reflect in vivo conditions. 2. We have studied the effect of agitation of the fluid in which cartilage is immersed upon the rate of
Alice Maroudas +3 more
openaire +3 more sources
Human stem cells and articular cartilage regeneration. [PDF]
, 2012 The regeneration of articular cartilage damaged due to trauma and posttraumatic osteoarthritis is an unmet medical need. Current approaches to regeneration and tissue engineering of articular cartilage include the use of chondrocytes, stem cells ...
Inui, Atsuyuki +2 more
core +4 more sources
Electrically Conductive Hydrogels for Articular Cartilage Tissue Engineering
Gels, 2022 Articular cartilage is a highly specialized tissue found in diarthrodial joints, which is crucial for healthy articular motion. Despite its importance, articular cartilage has limited regenerative capacities, and the degeneration of this tissue is a ...
Filipe Miguel +3 more
doaj +1 more source
Treatment of failed articular cartilage reconstructive procedures of the knee: A systematic review [PDF]
, 2018 Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have ...
Lamplot, Joseph D +2 more
core +2 more sources
The influences of walking, running and stair activity on knee articular cartilage: Quantitative MRI using T1 rho and T2 mapping. [PDF]
PLoS ONE, 2017 To explore the different influences of walking, running and stair activity on knee articular cartilage with T1 rho and T2 mapping sequences.MRI (3.0-T) scans of the right knee were performed in twenty-three young healthy adults immediately after 30 ...
Meng Chen +6 more
doaj +1 more source
Cryopreservation of articular cartilage
Cryobiology, 2013 Cryopreservation has numerous practical applications in medicine, biotechnology, agriculture, forestry, aquaculture and biodiversity conservation, with huge potentials for biological cell and tissue banking. A specific tissue of interest for cryopreservation is the articular cartilage of the human knee joint for two major reasons: (1) clinically, there
Abazari, Alireza +3 more
openaire +2 more sources
Study on the damage mechanism of articular cartilage based on the fluid–solid coupled particle model
Advances in Mechanical Engineering, 2015 Articular cartilage damage is the primary cause of osteoarthritis. Very little literature work focuses on the microstructural damage mechanism of articular cartilage.
Jun Hong, T Matthew Evans, Peter L Mente
doaj +1 more source