Results 31 to 40 of about 157,725 (283)

Treatment of Joint Cartilage Lesions with Cell Therapy [PDF]

open access: yes, 2008
Monográfico Osteoartritis[Resumen] Las lesiones del cartílago articular que no afectan a la integridad del hueso subcondral no se reparan espontáneamente.
Arufe, M.C.   +5 more
core   +2 more sources

The minor collagens in articular cartilage [PDF]

open access: yesProtein & Cell, 2017
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X,
Ali Mobasheri   +8 more
openaire   +6 more sources

Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model

open access: yesScientific Reports, 2017
The catabolism of hyaluronan in articular cartilage remains unclear. The aims of this study were to investigate the effects of hyaluronidase 2 (Hyal2) knockdown in articular cartilage on the development of osteoarthritis (OA) using genetic manipulated ...
Yoshitoshi Higuchi   +10 more
doaj   +1 more source

Effect of Micro-/Nanoparticle Hybrid Hydrogel Platform on the Treatment of Articular Cartilage-Related Diseases

open access: yesGels, 2021
Joint diseases that mainly lead to articular cartilage injury with prolonged severe pain as well as dysfunction have remained unexplained for many years.
Xu Han   +4 more
doaj   +1 more source

Direct Visualisation of the Depth-Dependent Mechanical Properties of Full-Thickness Articular Cartilage. [PDF]

open access: yes, 2012
The structural anisotropy of articular cartilage controls its deformation response. As proteoglycans and collagen vary with depth, simple uniaxial compression results in inhomogeneous deformation with distinct depth-dependent mechanical properties ...
Szarko, M, Xia, Y
core   +1 more source

A review of the differences between normal and osteoarthritis articular cartilage in human knee and ankle joints [PDF]

open access: yes, 2009
Background: Osteoarthritis (OA) is the most common joint disease yet its pathophysiology is still poorly understood. It is more prevalent in some lower limb joints than others; in particular the knee is more commonly affected than the ankle.
Beeson, Paul   +2 more
core   +1 more source

Morphological and mechanical alterations in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs

open access: yesFrontiers in Bioengineering and Biotechnology, 2023
Objectives: This study aimed to investigate the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs.Materials and methods: Hip joints of guinea pigs were investigated at 1,
Jiazi Gao, Pengling Ren, He Gong
doaj   +1 more source

Computational Models of Articular Cartilage [PDF]

open access: yesComputational and Mathematical Methods in Medicine, 2013
In osteoarthritis, articular cartilage degenerates and eventually wears out, resulting in pain and disability. It is a major challenge in health care to prevent osteoarthritis or slow down the progression of the disease. The onset of osteoarthritis may result from an altered stress and strain state in cartilage, for example, due to an injury of ...
Rami K. Korhonen   +3 more
openaire   +3 more sources

Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis

open access: yesBone Research, 2022
Runt-related transcription factor 1 (Runx1) plays a key role in cartilage formation, but its function in articular cartilage formation is unclear. We generated non-inducible and inducible Runx1-deficient mice (Runx1 f/f Col2α1-Cre and Runx1 f/f Col2α1 ...
Yan Zhang   +5 more
doaj   +1 more source

O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair

open access: yesBioactive Materials, 2023
Lacking self-repair abilities, injuries to articular cartilage can lead to cartilage degeneration and ultimately result in osteoarthritis. Tissue engineering based on functional bioactive scaffolds are emerging as promising approaches for articular ...
Yucong Li   +15 more
doaj   +1 more source

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