Results 61 to 70 of about 81,558 (199)
Arthroscopic Evaluation of Knee Cartilage Using Optical Reflection Spectroscopy
Arthroscopy Techniques, 2019 Articular cartilage is critical for painless and low-friction range of motion; however, disruption of articular cartilage, particularly in the knee joint, is common.
Justin L. Makovicka, M.D. +5 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan +16 more
wiley +1 more source
Systematic review of techniques in cartilage imaging
Journal of Cartilage & Joint PreservationIntroduction: This narrative review provides a historical overview and updates on the current status of qualitative and quantitative magnetic resonance imaging (MRI) for the evaluation of articular cartilage.
Mary Elizabeth Buchanan +1 more
doaj +1 more source
Advanced Science, EarlyView.Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen +6 more
wiley +1 more source
Nanozyme‐Integrated Hydrogel Targeting AGEs for Diabetic Osteoarthritis Therapy
Advanced Science, EarlyView.A nanozyme–integrated hydrogel (PTC‐MP) exhibiting with mild photothermal effects is constructed, and a “3R” (restrain‐restore‐reinforce) strategy is proposed for diabetic osteoarthritis (DOA) treatment based on advanced glycation end products (AGEs) targeting.
Rui Chen +8 more
wiley +1 more source
Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes
Advanced Science, EarlyView.In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu +13 more
wiley +1 more source
BioMedical Engineering OnLineArticular cartilage injury is a serious bone disease that can result in disabilities. With the rapid increase in the aging population, this disorder has become an increasingly important public health issue.
Chun-Sheng Li +8 more
doaj +1 more source
Osteoarthritis and Cartilage OpenIntroduction: Articular cartilage makes smooth movement possible and destruction of this tissue leads to loss of joint function. An important biomolecule that determines this function is the large aggregating proteoglycan of cartilage, aggrecan. Aggrecan
Peter M. van der Kraan +4 more
doaj +1 more source
Arthroscopy Techniques, 2016 Articular cartilage damage of the knee can cause severe morbidity. Owing to its avascular nature, articular cartilage has limited potential for self-healing and increased propensity to progress to osteoarthritis.
Chase S. Dean, M.D. +3 more
doaj +1 more source
Advanced Science, EarlyView.Collagen type I (Col I) is integrated with self‐assembling peptide RADA16 and loaded with anti‐bacterial peptide SAAP148 to develop a self‐assembled nano‐microstructure hydrogel (Col I‐RADA16‐SAAP148, CRS) without chemical cross‐linkers. CRS exhibits excellent mechanical properties, sustained SAAP148 release to inhibit bacterial infection, macrophage ...
Qian Liu +8 more
wiley +1 more source