Results 51 to 60 of about 715,314 (337)

Cellular senescence in aging and osteoarthritis: Implications for cartilage repair

Acta Orthopaedica, 2016
— It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis.
Wei Seong Toh, Mats Brittberg, Jack Farr, Casper Bindzus Foldager, Andreas H Gomoll, James Hoi Po Hui, James B Richardson, Sally Roberts, Myron Spector   +8 more
doaj   +1 more source

A Measure of Control for Secondary Cytokine-Induced Injury of Articular Cartilage: A Computational Study [PDF]

, 2013
In previous works, the author and collaborators establish a mathematical model for injury response in articular cartilage. In this paper we use mathematical software and computational techniques, applied to an existing model to explore in more detail how
Graham, Jason M
core  

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Vitamin D Receptor Genetic Polymorphisms Associate With a Decreased Susceptibility to Extremity Osteomyelitis Partly by Inhibiting Macrophage Apoptosis Through Inhibition of Excessive ROS Production via VDR-Bmi1 Signaling

Frontiers in Physiology, 2022
Background: Previous studies had reported that vitamin D receptor (VDR) gene polymorphisms were related to the development of several inflammatory disorders. However, potential links between such variations and the risk of developing a bone infection and
Xing-Qi Zhao, Xing-Qi Zhao, Hao-Yang Wan, Hao-Yang Wan, Si-Ying He, Si-Ying He, Han-Jun Qin, Han-Jun Qin, Bin Yu, Bin Yu, Nan Jiang, Nan Jiang   +11 more
doaj   +1 more source

Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. [PDF]

, 2019
Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly associated with subchondral bone sclerosis. However, the cellular mechanisms responsible for changes to subchondral bone in OA, and the extent to which these ...
Acevedo, Claire, Alliston, Tamara, Bailey, Karsyn N, Dang, Alexis, Fields, Aaron J, Fowler, Tristan W, Kaya, Serra, Kuo, Alfred C, Lotz, Jeffrey C, Mazur, Courtney M, Vail, Thomas P, Woo, Jonathon J, Yee, Cristal S   +12 more
core  

Viscoelastic deformation of articular cartilage during impact loading [PDF]

, 2010
Peer ...
Aspden, Richard M., Burgin, Leanne V., Edelsten, Lorna, Jeffrey, Janet E.   +3 more
core   +1 more source

Comparison of clinical outcomes following osteochondral allograft transplantation for osteochondral versus chondral defects in the knee

Knee Surgery & Related Research, 2022
Purpose Osteochondral allograft (OCA) transplantation is a restorative technique for addressing articular cartilage defects by transferring mature viable chondrocytes with subchondral bone into size-matched lesions.
John Reza Matthews, Joseph Brutico, Jeremy Heard, Kashyap Chauhan, Bradford Tucker, Kevin Blake Freedman   +5 more
doaj   +1 more source

MACI (autologous cultured chondrocytes on porcine collagen membrane) in patients 40 years and older: short-term clinical outcomes and patient satisfaction

Journal of Cartilage & Joint Preservation, 2023
Introduction: Cartilage restoration in the middle-aged population (40-60 years) is understudied. Objectives: The purpose of this study is to report the clinical outcomes and satisfaction of patients over the age of 40 years old who underwent autologous ...
Liana Leja, Tom Minas
doaj   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Prevalence of Pincer Morphology in Early Adolescents From the General Population: A Population‐Based Study

Arthritis Care &Research, EarlyView.
Objective Pincer morphology can lead to femoroacetabular impingement syndrome (FAIS) and may be a modifiable risk factor for hip osteoarthritis (OA). Currently, no studies investigate the prevalence of pincer morphology in early adolescence, which is the period when this bony shape likely develops.
Delong Chen, Fleur Boel, Suzanne de Vos‐Jakobs, Pim van Klij, Michiel M. A. van Buuren, Sita M. A. Bierma‐Zeinstra, Rintje Agricola   +6 more
wiley   +1 more source