Results 161 to 170 of about 87,840 (204)

Hyaline cartilage degenerates after autologous osteochondral transplantation

Journal of Orthopaedic Research, 2004
AbstractObjectives: Autologous osteochondral grafting is a well‐established clinical procedure to treat focal cartilage defects in patients, although basic research on this topic remains sparse. The aim of the current study was to evaluate (1) histological changes of transplanted hyaline cartilage of osteochondral grafts and (2) the tissue that ...
C O, Tibesku, T, Szuwart, T O, Kleffner, P M, Schlegel, U R, Jahn, H, Van Aken, S, Fuchs   +6 more
openaire   +2 more sources

Symptomatic Articular Cartilage Degeneration

Clinical Orthopaedics and Related Research, 2001
The symptomatic degeneration of articular cartilage and associated arthritis is among the most prevalent chronic conditions in the United States and the population most at risk is increasing. It is the leading cause of limitations in activities of daily living and is second to heart disease in causing work disability.
D W, Jackson, T M, Simon, H M, Aberman
openaire   +2 more sources

DNA Methylation, Chondrogenesis, and Cartilage Degeneration

Current Rheumatology Reviews, 2006
In the last few years there has been an explosion of research into epigenetics and, in particular, the roles of DNA methylation in the normal functioning of the mammalian organism as well as whether changes in methylation status contribute to or cause aberrant gene expression in diseases.
Thomas Aigner, Pia Margarethe Gebhard, Stephan Sesselmann, Stephan Soder, Helmtrud Roach   +4 more
openaire   +1 more source

The association between meniscal subluxation and cartilage degeneration

European Journal of Orthopaedic Surgery and Traumatology, 2012
The menisci play a critical protective role for the knee joint through shock absorption and load distribution. We hypothesized that cartilage degeneration will be abruptly progressed if meniscal subluxation exceeds a critical point.Of 56 cases that showed medial meniscal subluxation without cartilage degeneration of ipsilateral medial femoral condyle ...
Young Rak Choi, Keun Jung Ryu
exaly   +3 more sources

Articular Cartilage: Homeostasis, Aging and Degeneration

2020
Aging implies changes in articular cartilage cells and the surrounding extracellular matrix (ECM) that are reflective of metabolic changes related to time alone. For chondrocytes, these are genomic and intracytoplasmic changes that lessen their capacity to respond and control their extracellular environment; for the matrix, these are changes that lead ...
Kenneth P. H. Pritzker, Harpal K. Gahunia   +1 more
openaire   +1 more source

The effect of cartilage degeneration on ultrasound speed in human articular cartilage

Modern Rheumatology, 2015
We investigated the effect of cartilage degeneration on ultrasound speed in human articular cartilage in vitro.Ultrasound speed was calculated by the time-of-flight method for 22 femoral condyle osteochondral blocks obtained from osteoarthritis patients. In parallel, histological evaluation of specimens was performed using the modified Mankin and OARSI
Satoru, Ohashi, Isao, Ohnishi, Hiroyuki, Oka, Takuya, Matsumoto, Masahiko, Bessho, Kozo, Nakamura, Sakae, Tanaka   +6 more
openaire   +2 more sources

Cartilage repair surgery prevents progression of knee degeneration

Knee Surgery, Sports Traumatology, Arthroscopy, 2018
To investigate, whether cartilage repair surgery for focal osteochondral defects at the knee results in less degenerative changes over 6 years in a MR imaging follow-up than morphologically initially identical defects in non-operated control subjects from the osteoarthritis initiative (OAI).A total of 32 individuals received baseline and follow-up MRI.
Jungmann, Pia M, Gersing, Alexandra S, Baumann, Frederic, Holwein, Christian, Braun, Sepp, Neumann, Jan, Zarnowski, Julia, Hofmann, Felix C, Imhoff, Andreas B, Rummeny, Ernst J, Link, Thomas M   +10 more
openaire   +3 more sources

Osteoarthritis: Cellular and molecular changes in degenerating cartilage

Progress in Histochemistry and Cytochemistry, 2006
Osteoarthritis (OA) is a disease of high ethical and economical importance. In advanced stages, the patients suffer from severe pain and restriction of mobility. The consequence in many cases is an inability to work and often the substitution of the diseased joint with an artificial implant becomes inevitable.
Helga, Lorenz, Wiltrud, Richter
openaire   +2 more sources

New methods to diagnose and treat cartilage degeneration

Nature Reviews Rheumatology, 2009
Lesions in articular cartilage can result in significant musculoskeletal morbidity and display unique biomechanical characteristics that make repair difficult, at best. Several surgical procedures have been devised in an attempt to relieve pain, restore function, and delay or stop the progression of cartilaginous lesions.
Robert J, Daher, Nadeen O, Chahine, Andrew S, Greenberg, Nicholas A, Sgaglione, Daniel A, Grande   +4 more
openaire   +2 more sources

High-resolution imaging of progressive articular cartilage degeneration

Journal of Orthopaedic Research, 2006
The objective of this study was to develop and verify a new technique for monitoring the progression of osteoarthritis (OA) by combining a rat model with the imaging modality optical coherence tomography (OCT). Time-sequential, in vivo, OCT imaging was performed on the left femoral condyles of 12 Wistar rats following sodium-iodoacetic acid-induced OA ...
Samuel B, Adams, Paul R, Herz, Debra L, Stamper, Mark J, Roberts, Stephane, Bourquin, Nirlep A, Patel, Karl, Schneider, Scott D, Martin, Sonya, Shortkroff, James G, Fujimoto, Mark E, Brezinski   +10 more
openaire   +2 more sources