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Indian hedgehog contributes to human cartilage endplate degeneration
European Spine Journal, 2015To determine the role of Indian hedgehog (Ihh) signaling in human cartilage endplate (CEP) degeneration.CEP-degenerated tissues from patients with Modic I or II changes (n = 9 and 45, respectively) and normal tissues from vertebral burst fracture patients (n = 17) were collected.
Shaowei, Wang +6 more
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MECHANO-ACOUSTIC DIAGNOSIS OF CARTILAGE DEGENERATION AND REPAIR
The Journal of Bone and Joint Surgery-American Volume, 2003The combined use of high-frequency ultrasound and mechanical indentation has been suggested for the evaluation of cartilage integrity. In this study, we investigated the usefulness of high-resolution B-mode ultrasound imaging and quantitative mechanical measurements for the diagnosis of cartilage degeneration and for monitoring tissue-healing after ...
Mikko S, Laasanen +7 more
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The Mechanobiology of Articular Cartilage Development and Degeneration
Clinical Orthopaedics & Related Research, 2004The development, maintenance, and destruction of cartilage are regulated by mechanical factors throughout life. Mechanical cues in the cartilage fetal endoskeleton influence the expression of genes that guide the processes of growth, vascular invasion, and ossification. Intermittent fluid pressure maintains the cartilage phenotype whereas mild tension (
Dennis R, Carter +5 more
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A New Device to Detect Early Cartilage Degeneration
The American Journal of Sports Medicine, 2004Background Currently available arthroscopic techniques do not allow the quantification of cartilage stiffness without direct mechanical indentation or penetration of the tissue. Purpose A novel device, capable of quantifying cartilage stiffness during arthroscopy, is believed to detect degenerated cartilage.
Georg N, Duda +3 more
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Cartilage intermediate layer protein promotes lumbar disc degeneration
Biochemical and Biophysical Research Communications, 2014Lumbar disc disease (LDD) is one of the most common musculoskeletal disorders, and accompanies intervertebral disc degeneration. CILP encodes cartilage intermediate layer protein, which is highly associated with LDD. Moreover, CILP inhibits transcriptional activation of cartilage matrix genes in nucleus pulposus (NP) cells in vitro by binding to TGF-β1
Shoji Seki +11 more
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An assessment of equine cartilage degeneration.
Biomedical sciences instrumentation, 2004Millions of Americans suffer from osteoarthritis, a joint disease characterized by cartilage degradation and subchondral bone sclerosis. However, little is known about its pathology. It remains to be discovered which comes first in the progression of osteoarthritis: subchondral bone remodeling or cartilage degeneration.
Jennifer L, Harmel +4 more
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Overloading stress–induced progressive degeneration and self‐repair in condylar cartilage
Annals of the New York Academy of Sciences, 2021Lingli Fang, Yao He
exaly
JUNB‐FBXO21‐ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy
Aging Cell, 2021Zhiming Lin, lunhao bai
exaly
Cartilage Degeneration and Regeneration
Clinical Orthopaedics & Related Research, 2004openaire +1 more source