Results 171 to 180 of about 315,650 (233)

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

Electroacupuncture Alleviates KOA-Induced Pain and Cartilage Degeneration via NGF/TrkA Pathway. [PDF]

J Pain Res
Fu Y, Lin L, Chen W, Shi G, Li HP, Tu JF, Liu CZ.   +6 more
europepmc   +1 more source

Plasma and Synovial Fluid VEGF‐A and Neuropilin‐1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization‐Related Features, and Disease Burden

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF‐A) and neuropilin‐1 (NRP1) levels with radiographic severity, pain sensitization‐related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF‐A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (
Cheng‐Ju Tan
wiley   +1 more source

Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis. [PDF]

Bioact Mater
He C, Huang G, Moradi L, Bi J, Yang X, Liu X, Cui X, Varthi A, Wiznia DH, Waxman SG, Fu W, Liu CJ.   +11 more
europepmc   +1 more source

IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A‐Dependent Stabilization of ECM1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) plays a critical role in osteoarthritis (OA) pathogenesis. This study investigates the role of the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in OA progression. OA models were established in vivo through destabilization of the medial meniscus (DMM) surgery in mice and in vitro by ...
Xing‐Shi Yuan, Hao‐Jie Zhang, Jia‐Xiang Ding, Zheng‐Liang Luo, Min Chen, Xiao‐Qi Zhang, Xi‐Fu Shang, Zhe Ni, Ke‐Rong Wu   +8 more
wiley   +1 more source

Altered nicotinamide adenine dinucleotide metabolism drives cartilage degeneration and osteoarthritis. [PDF]

Clin Transl Med
Wu X, Fan X, Plan M, Stark T, McCubbin T, Barrero RA, Marinova M, Bertoldo MJ, Goss DM, Wu LE, Crawford R, Mao X, Prasadam I.   +12 more
europepmc   +1 more source

Age, sex and graft choice are associated with the achievement of a patient acceptable symptom state five years after primary ACL reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To determine the proportion of patients and the factors associated with the achievement of a patient‐acceptable symptom state (PASS) 5 years after primary anterior cruciate ligament reconstruction (ACLR). Methods Patients who underwent primary ACLR between 2005 and 2018 at Capio Artro Clinic, Stockholm, Sweden, were eligible for ...
Firathan Koca, Christoffer von Essen, Eric Hamrin Senorski, Kristian Samuelsson, Anders Stålman, Riccardo Cristiani   +5 more
wiley   +1 more source

RIPK3 is spatially associated with cartilage degeneration in osteoarthritis: integrative transcriptomic and histological analysis. [PDF]

J Orthop Surg Res
Wang L, Tang J, Niu L, Li Z, Wu L, Zhao W, Wang G.   +6 more
europepmc   +1 more source

Autologous minimally manipulated adipose‐derived stromal vascular fraction in knee osteoarthritis: Lasting symptom relief and imaging evidence from a 12‐month prospective study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate the safety and efficacy of intra‐articular autologous transplantation of adipose‐derived connective tissue micrografts rich in stromal vascular fraction (CTM‐SVF), obtained using an enzyme‐free system (Hy‐Tissue® SVF) for knee osteoarthritis (OA). Methods Thirty patients (mean age of 53.3 ± 6.4 years) with Kellgren–Lawrence
Laura Mangiavini, Nicolò Rossi, Riccardo Giorgino, Francesco Borelli, Alessandra Colombini, Paola De Luca, Simona Landoni, Luca Maria Sconfienza, Carmelo Messina, Irene Beriotto, Giuseppe M. Peretti, Laura de Girolamo   +11 more
wiley   +1 more source

Increased joint line obliquity is associated with lateral cartilage degeneration after medial opening wedge high tibial osteotomy: a quantitative MRI analysis. [PDF]

Knee Surg Relat Res
Hiranaka T, Dal Fabbro G, O'Brien K, Linklater J, A Parker D.   +4 more
europepmc   +1 more source