Results 71 to 80 of about 315,650 (233)

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Cellular and molecular response to mechanical articular cartilage injury [PDF]

, 2010
PhDJoint injures frequently involve structural damage to articular cartilage and the underlying subchondral bone. The outcome of acute joint surface defects (JSD) varies from spontaneous healing to the development of post-traumatic osteoarthritis (PTOA).
Eltawil, Noha
core   +3 more sources

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source

Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1–HIF1α‐mediated glycolysis–OXPHOS metabolism shift

Clinical and Translational Medicine
Introduction Developmental dysplasia of hip (DDH) is a hip joint disorder leading to subsequent osteoarthritis. Previous studies suggested collagen XI alpha 1 (COL11A1) as a potential gene in hip dysplasia and chondrocyte degeneration.
Ye Sun, Yongqing You, Qiang Wu, Rui Hu, Kerong Dai   +4 more
doaj   +1 more source

The Effect of PRP & Fat Grafting on Viability of Cartilage Grafts: An Experimental Study [PDF]

Egyptian Journal of Plastic and Reconstructive Surgery
Background: Cartilage tissue has limited capacity for regenerationmainly due to its avascular nature. As a result, cartilagedeficiencies treatment has always been a difficult problemfor surgeons.Objectives: To evaluate the safety and effectiveness ofPRP ...
Khaled Abdelazeem, Emad Hawas, Wael Sakr, Ahmed Ibrahim, Osama Ahmed, Mostafa Fathy   +5 more
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

A feasibility study of in vivo quantitative ultra-short echo time-MRI for detecting early cartilage degeneration

Insights into Imaging
Objectives To explore the feasibility of Ultra-short echo time (UTE) – MRI quantitative imaging in detecting early cartilage degeneration in vivo and underlying pathological and biochemical basis.
Xiaolian Su, Yitong Wang, Jieying Chen, Zonghui Liang, Lidi Wan, Guangyu Tang   +5 more
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Correlation between functional impairment and quantitative MRI assessment of ankle cartilage in chronic ankle instability

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
Background: Chronic ankle instability (CAI) is characterized by persistent ankle pain, instability, and recurrent sprains. Previous studies have investigated functional impairments and cartilage degeneration separately, but the relationship between them ...
Zichun Liu, Shanshan Zheng, Haoxiong Li, Xiao'ao Xue, Tian Xia, Yuwen Zhang, Ying-Hua Chu, Qing Li, Weijun Tang, Shangxuan Shi, Yinghui Hua, Rong Lu   +11 more
doaj   +1 more source