Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice. [PDF]
, 2015 IntroductionPrevious studies in animal models of osteoarthritis suggest that alendronate (ALN) has antiresorptive and chondroprotective effects, and can reduce osteophyte formation.
Anderson, Matthew J +6 more
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Orthopaedic Journal of Sports Medicine, 2017 Purpose: The purpose of this study was to evaluate the prevalence and risk factor of cartilage degeneration of patellofemoral joint (PFJ) that was diagnosed by second look arthroscopy in the short term follow-up period.
Sang Hak Lee, Kyung Ho Yoon, Chan Il Bae
doaj +1 more source
Operative treatment for pincer type femoroacetabular impingement:a case report [PDF]
, 2010 Femoroacetabular impingement (FAI) is a condition characterized by the impingement of the femur and acetabulum. In Japan, this disorder has become recognized gradually.
Endo, Hirosuke +6 more
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Chronic tendon pathology: molecular basis and therapeutic implications [PDF]
, 2005 Tendons are frequently affected by chronic pain or rupture. Many causative factors have been implicated in the pathology, which until relatively recently was under-researched and poorly understood.
Riley, GP
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Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. [PDF]
, 2019 Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly associated with subchondral bone sclerosis. However, the cellular mechanisms responsible for changes to subchondral bone in OA, and the extent to which these ...
Acevedo, Claire +12 more
core
WISP1/CCN4 aggravates cartilage degeneration in experimental osteoarthritis [PDF]
Osteoarthritis and Cartilage, 2017 Increased Wisp1 expression was previously reported in experimental and human osteoarthritis (OA). Moreover, adenoviral overexpression of Wisp1 in naïve mouse knee joints resulted in early OA-like cartilage lesions. Here, we determined how the matricellular protein WISP1 is involved in the pathology that occurs in the complex osteoarthritic environment ...
van den Bosch, M.H.J. +11 more
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Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications
Frontiers in Cell and Developmental Biology, 2021 The involvement of histone modifications in cartilage development, pathology and regeneration is becoming increasingly evident. Understanding the molecular mechanisms and consequences of histone modification enzymes in cartilage development, homeostasis ...
Chao Wan +12 more
doaj +1 more source
NG2/CSPG4 regulates cartilage degeneration during TMJ osteoarthritis
Frontiers in Dental Medicine, 2022 Changes in the mechanical homeostasis of the temporomandibular joint (TMJ) can lead to the initiation and progression of degenerative arthropathies such as osteoarthritis (OA). Cells sense and engage with their mechanical microenvironment through interactions with the extracellular matrix.
David A. Reed +6 more
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Exercise improves subchondral bone microenvironment through regulating bone-cartilage crosstalk
Frontiers in Endocrinology, 2023 Articular cartilage degeneration has been proved to cause a variety of joint diseases, among which osteoarthritis is the most typical. Osteoarthritis is characterized by articular cartilage degeneration and persistent pain, which affects the quality of ...
Shihua Zhang +9 more
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Preliminary characterisation of the surface of cartilage following exposure to saturated and unsaturated synthetic lips [PDF]
, 2011 Articular cartilage is covered by a microscopic structure known as surface amorphous layer. This surface structure is often the first victim of attack during cartilage degeneration, thereby resulting in a gross impairment in cartilage function such as ...
Gudimetla, Prasad +3 more
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