Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. [PDF]
, 2019 Poor solute transport through the cartilage endplate (CEP) impairs disc nutrition and could be a key factor that limits the success of intradiscal biologic therapies.
Dolor, Aaron +5 more
core +2 more sources
Cartilage Endplate and its Role in Disk Degeneration (Analytical Review of the Literature)
Bolʹ, Sustavy, Pozvonočnik, 2012 This review summarizes the current literature data on the structure and function of the cartilage endplate in humans and animals. Age aspect of the cartilage endplate changes and its disturbances in disk degeneration is presented.
L.M. Bengus, N.V. Dedukh
doaj +1 more source
ADAM10 Localization in Temporomandibular Joint Disk with Internal Derangement: An Ex Vivo Immunohistochemical Study [PDF]
, 2016 The purpose of this study was to determine the presence of ADAM10 in temporomandibular joint disk with internal derangement. Twenty-five paraffin blocks of displaced temporomandibular joint (TMJ) disk specimens from earlier investigations were retrieved ...
Almeida, Luis Eduardo +7 more
core +2 more sources
Lubricin Immunohistochemical Expression in Human Temporomandibular Joint Disc with Internal Derangement [PDF]
, 2011 Lubricin is a chondroprotective, mucinous glycoprotein which contribute to joint lubrication, especially to boundary lubrication and maintains joint integrity.
Almeida, Luis Eduardo +2 more
core +2 more sources
lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
Stem Cell Research & Therapy, 2019 With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced.
Jian Zhu +10 more
doaj +1 more source
Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature [PDF]
, 2016 Background: Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes representing different mechanisms ...
Allan, R. +4 more
core +3 more sources
Bone Reports, 2023 Subchondral bone participates in crosstalk with articular cartilage to maintain joint homeostasis, and disruption of either tissue results in overall joint degeneration. Among the subchondral bone changes observed in osteoarthritis (OA), subchondral bone
Serra Kaya +4 more
doaj +1 more source
Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery [PDF]
, 2019 Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used
Akk, Antonina +7 more
core +3 more sources
Impact of degeneration and material pairings on cartilage friction: Cartilage versus glass
Journal of Orthopaedic Research, 2023 AbstractThe association of knee joint osteoarthritis and altered frictional properties of the degenerated cartilage remains ambiguous, because previous in vitro studies did not consider the characteristic loads and velocities during gait. Therefore, the aim of this study was to quantify the friction behavior of degenerated human cartilage under ...
de Roy, Luisa +5 more
openaire +3 more sources
Current evidence for a modulation of low back pain by human genetic variants [PDF]
, 2009 The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle +200 more
core +1 more source