Results 11 to 20 of about 87,840 (204)

Significance of Necroptosis in Cartilage Degeneration. [PDF]

Biomolecules
Cartilage, a critical tissue for joint function, often degenerates due to osteoarthritis (OA), rheumatoid arthritis (RA), and trauma. Recent research underscores necroptosis, a regulated form of necrosis, as a key player in cartilage degradation. Unlike apoptosis, necroptosis triggers robust inflammatory responses, exacerbating tissue damage.
Khaleque MA, Kim JH, Tanvir MAH, Park JB, Kim YY.   +4 more
europepmc   +4 more sources

Indentation diagnostics of cartilage degeneration [PDF]

Osteoarthritis and Cartilage, 2008
Mechanical indentation and ultrasound (US) indentation instruments have been introduced for quantitative assessment of cartilage properties in vivo. In this study, we compared capabilities of these instruments to determine properties of healthy and spontaneously degenerated human patellar cartilage in situ and to diagnose the early stages of ...
Kiviranta, P., Lammentausta, E., Töyräs, J., Kiviranta, I., Jurvelin, J. S.   +4 more
openaire   +3 more sources

Salicylate inhibition of cartilage degeneration [PDF]

Arthritis & Rheumatism, 1965
AbstractSodium salicylate significantly inhibits the ability of saline extracts of human articular cartilage to decrease the viscosity of chondromucoprotein. Two groups of rabbits were subjected to superficial scarification of their knee articular cartilage.
D P, Simmons, O D, Chrisman
openaire   +2 more sources

Nutrition and degeneration of articular cartilage [PDF]

Knee Surgery, Sports Traumatology, Arthroscopy, 2012
AbstractPurposeTo determine the importance of synovial fluid (SF) or subchondral bone marrow (BM) as nutrition sources in cartilage degeneration.MethodsNinety‐five‐month‐old male rabbits were randomly divided into 5 groups according to sources of nutrition: SFBM‐both; BM‐only; SF‐only; None‐SFBM; and Free plug (unrestricted). Nutrition to 4‐mm‐diameter
Wang, Yuze, Wei, Lei, Zeng, Lingyuan, He, Dongdong, Wei, Xiaochun   +4 more
openaire   +2 more sources

Spontaneous cartilage degeneration in guinea pigs [PDF]

Arthritis & Rheumatism, 1988
AbstractSpontaneous degeneration of the knee joint cartilage in male Hartley guinea pigs was studied by light microscopy in animals aged 3–18 months. Unilateral focal degeneration, characterized by chondrocyte death and proteoglycan loss with surface fibrillation, was observed on the medial tibial plateau in 2 of 5 guinea pigs that were 3 months old ...
A M, Bendele, J F, Hulman
openaire   +2 more sources

Comparison of properties determined using electromechanical assessment (Arthro-BST™) with macroscopic and histological properties in symptomatic human articular cartilage of the hip

Arthritis Research & Therapy, 2021
Background Cartilage degeneration is assessed using various methods. Although macroscopic evaluation can directly measure cartilage degeneration, it cannot accurately assess cartilage properties.
Taku Ukai, Masato Sato, Shiho Wasai, Takumi Takahashi, Haruka Omura, Masahiko Watanabe   +5 more
doaj   +1 more source

Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice. [PDF]

, 2020
Aging and injury are two major risk factors for osteoarthritis (OA). Yet, very little is known about how aging and injury interact and contribute to OA pathogenesis.
Christiansen, Blaine A, Hum, Nicholas R, Loots, Gabriela G, McCool, Jillian L, Mendez, Melanie E, Murugesh, Deepa K, Rios-Arce, Naiomy D, Sebastian, Aimy   +7 more
core   +2 more sources

Persistent Biomechanical Alterations After ACL Reconstruction Are Associated With Early Cartilage Matrix Changes Detected by Quantitative MR. [PDF]

, 2016
BackgroundThe effectiveness of anterior cruciate ligament (ACL) reconstruction in preventing early osteoarthritis is debated. Restoring the original biomechanics may potentially prevent degeneration, but apparent pathomechanisms have yet to be described.
Amano, Keiko, Li, Xiaojuan, Ma, C Benjamin, Pedoia, Valentina, Souza, Richard B, Su, Favian   +5 more
core   +6 more sources

Preoperative flexion contracture is a predisposing factor for cartilage degeneration at the patellofemoral joint after open wedge high tibial osteotomy

Knee Surgery & Related Research, 2020
Purpose The purpose of the study was to determine the effect of cartilage degeneration at the patellofemoral joint on clinical outcomes after open wedge high tibial osteotomy and to investigate the predisposing factors for progressive patellofemoral ...
Shuhei Otsuki, Kuniaki Ikeda, Hitoshi Wakama, Nobuhiro Okuno, Yoshinori Okamoto, Tomohiro Okayoshi, Yuki Miyamoto, Masashi Neo   +7 more
doaj   +1 more source

Hypoxia-inducible factor expression is related to apoptosis and cartilage degradation in temporomandibular joint osteoarthritis

BMC Musculoskeletal Disorders, 2022
Background It remains unclear etiology of cartilaginous tissues in osteoarthritis (OA) lesions. In this study, we hypothesized the accumulation of hypoxia-inducible factor (HIF) and activated apoptosis relate to condylar cartilage degeneration in vivo ...
Jun Zhang, Yu Hu, Zihan Wang, Xuelian Wu, Chun Yang, Hefeng Yang   +5 more
doaj   +1 more source