Results 11 to 20 of about 315,650 (233)

The biology of the ovine functional spinal unit: facet cartilage and intervertebral disc [PDF]

, 2013
Back pain will affect up to 84 % of people at some point in their lives. It is a major public health problem in Western society leading to disability and economic loss through work absence, physician visits and hospitalisation.
Gough, Caroline Shanni
core   +6 more sources

Contact mechanics modelling of articular cartilage and applications [PDF]

, 2006
Osteoarthritis (OA) is a degenerative disease of articular cartilage. The normal cartilage is known to be an excellent bearing material with remarkable lubricating properties and very low frictional co-efficient and wear and generally survives the ...
Pawaskar, Sainath Shrikant
core   +6 more sources

Joint contact modelling of articular cartilage in synovial joints [PDF]

, 2010
Hip joint is one of the important load bearing joints and has been extensively studied to investigate contact mechanics and tribology. It has known to experience high contact forces and stresses.
Pawaskar, Sainath Shrikant
core   +7 more sources

Hypoxia-inducible factor expression is related to apoptosis and cartilage degradation in temporomandibular joint osteoarthritis

BMC Musculoskeletal Disorders, 2022
Background It remains unclear etiology of cartilaginous tissues in osteoarthritis (OA) lesions. In this study, we hypothesized the accumulation of hypoxia-inducible factor (HIF) and activated apoptosis relate to condylar cartilage degeneration in vivo ...
Jun Zhang, Yu Hu, Zihan Wang, Xuelian Wu, Chun Yang, Hefeng Yang   +5 more
doaj   +1 more source

Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4

Nature Communications, 2022
This study demonstrates a role of cholesterol metabolism-related gene, Lrp3, in cartilage degeneration and osteoarthritis pathogenesis. LRP3 positively regulates cartilage extracellular matrix metabolism by targeting syndecan-4 via Ras signalling ...
Chenxi Cao, Yuanyuan Shi, Xin Zhang, Qi Li, Jiahao Zhang, Fengyuan Zhao, Qingyang Meng, Wenli Dai, Zhenlong Liu, Wenqiang Yan, Xiaoning Duan, Jiying Zhang, Xin Fu, Jin Cheng, Xiaoqing Hu, Yingfang Ao   +15 more
doaj   +1 more source

The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis

Frontiers in Cell and Developmental Biology, 2022
Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis (OA), a prevalent progressive degenerative joint disease that causes debilitating pain.
Winni Gao, Hamza Hasan, Devon E. Anderson, Devon E. Anderson, Whasil Lee, Whasil Lee, Whasil Lee, Whasil Lee   +7 more
doaj   +1 more source

Mild treadmill exercise inhibits cartilage degeneration via macrophages in an osteoarthritis mouse model

Osteoarthritis and Cartilage Open, 2023
Objective: We previously reported how treadmill exercise can suppress cartilage degeneration. Here, we examined the changes in macrophage dynamics in knee osteoarthritis (OA) during treadmill exercise and the effect of macrophage depletion.
Yuichiro Oka, Kenji Murata, Kaichi Ozone, Yuki Minegishi, Takuma Kano, Naoki Shimada, Naohiko Kanemura   +6 more
doaj   +1 more source

The effect of mechanical stress on the stiffness of articular cartilage and its role in the aetiology of osteoarthrosis [PDF]

, 1988
Although a substantial amount is known about the pathogenesis of osteoarthrosis, its aetiology and in particular the role that mechanical factors play, remains unclear.
Swann, Anthony Charles
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Changes in articular cartilage after meniscectomy and meniscus replacement using a biodegradable porous polymer implant [PDF]

, 2010
Purpose: To evaluate the long-term effects of implantation of a biodegradable polymer meniscus implant on articular cartilage degeneration and compare this to articular cartilage degeneration after meniscectomy.
Arend Jan Schouten, Buma, Pieter,, Schouten, Arend Jan,, Hannink, Gerjon, Buma, P., Buma, Pieter, Tienen, Tony G. van,, Tienen, T.G. van, Gerjon Hannink, Pieter Buma, Tienen, Tony G. van, Hannink, G.J., Schouten, A.J., Tony G. van Tienen, van Tienen, Tony G., Schouten, Arend Jan, de Mulder, E.L., Hannink, Gerjon,   +17 more
core   +6 more sources

Increase in cartilage degeneration in all knee compartments after failed ACL reconstruction at 4 years of follow-up

Journal of Orthopaedics and Traumatology, 2021
Purpose Degeneration of the cartilage after anterior cruciate ligament reconstruction (ACL-R) is known, and further deterioration can be expected in patients with tunnel malplacement or partial meniscal resection.
Kathleen Andrä, Robert Prill, Enes Kayaalp, Lars Irlenbusch, Eckehard Liesaus, Tilo Trommer, Peter Ullmann, Roland Becker   +7 more
doaj   +1 more source