Results 21 to 30 of about 315,650 (233)

Sex-dependent variation in cartilage adaptation: from degeneration to regeneration

Biology of Sex Differences, 2023
Highlights Evidence indicates males and females respond differently to cartilage degeneration and regeneration. Few review articles available provide comprehensive information referencing clinical and laboratory research.
Jhanvee Patel, Song Chen, Torey Katzmeyer, Yixuan Amy Pei, Ming Pei   +4 more
doaj   +1 more source

A review of the differences between normal and osteoarthritis articular cartilage in human knee and ankle joints [PDF]

, 2009
Background: Osteoarthritis (OA) is the most common joint disease yet its pathophysiology is still poorly understood. It is more prevalent in some lower limb joints than others; in particular the knee is more commonly affected than the ankle.
Beeson, Paul, Hendren, Linda, The University of Northampton   +2 more
core   +1 more source

Cartilage Endplate and its Role in Disk Degeneration (Analytical Review of the Literature)

Bolʹ, Sustavy, Pozvonočnik, 2012
This review summarizes the current literature data on the structure and function of the cartilage endplate in humans and animals. Age aspect of the cartilage endplate changes and its disturbances in disk degeneration is presented.
L.M. Bengus, N.V. Dedukh
doaj   +1 more source

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +1 more source

3D printed porous sulfonated polyetheretherketone scaffold for cartilage repair: Potential and limitation

Journal of Orthopaedic Translation, 2022
Objective: The treatment of cartilage lesions has always been a difficult problem. Although cartilage tissue engineering provides alternative treatment options for cartilage lesions, biodegradable tissue engineering scaffolds have limitations.
Zhiguo Yuan, Teng Long, Jue Zhang, Zhuocheng Lyu, Wei Zhang, Xiangchao Meng, Jin Qi, You Wang   +7 more
doaj   +1 more source

lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration

Stem Cell Research & Therapy, 2019
With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced.
Jian Zhu, Wei Yu, Yitian Wang, Kaishun Xia, Yuluan Huang, Ankai Xu, Qixin Chen, Bing Liu, Huimin Tao, Fangcai Li, Chengzhen Liang   +10 more
doaj   +1 more source

Longitudinal measurement of serum cartilage oligomeric matrix protein can detect the progression of cartilage degeneration in anterior cruciate ligament reconstruction patients

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
Background/objective: Cartilage oligomeric matrix protein (COMP) has utility as a diagnostic marker for osteoarthritis (OA). Our previous study revealed that the serum COMP level can be used to detect early cartilage change in non-OA patients with ...
Yohei Nishida, Yusuke Hashimoto, Kumi Orita, Kazuya Nishino, Takuya Kinoshita, Ken Iida, Hiroaki Nakamura   +6 more
doaj   +1 more source

Bone-cartilage crosstalk informed by aging mouse bone transcriptomics and human osteoarthritis genome-wide association studies

Bone Reports, 2023
Subchondral bone participates in crosstalk with articular cartilage to maintain joint homeostasis, and disruption of either tissue results in overall joint degeneration. Among the subchondral bone changes observed in osteoarthritis (OA), subchondral bone
Serra Kaya, Karsyn N. Bailey, Charles A. Schurman, Daniel S. Evans, Tamara Alliston   +4 more
doaj   +1 more source

Tenascin-C fragments are endogenous inducers of cartilage matrix degradation [PDF]

, 2011
Cartilage destruction is a hallmark of osteoarthritis (OA) and is characterized by increased protease activity resulting in the degradation of critical extracellular matrix (ECM) proteins essential for maintaining cartilage integrity.
Hermansson, M, Saralili Dipa Robertson, Wait, R, Robertson, SD, Wait, Robin, Monika Hermansson, Jonathan Jones, Philip Mitchell, Mitchell, P, Sofat, N, Nidhi Sofat, Jones, J, Robin Wait   +12 more
core   +1 more source

Mechanism of YAP1 in the senescence and degeneration of endplate chondrocytes induced by intermittent cyclic mechanical tension

Journal of Orthopaedic Surgery and Research, 2023
Background This study aimed to investigate the potential mechanism of YAP1 in the senescence and degeneration of endplate chondrocytes induced by intermittent cyclic mechanical tension (ICMT).
Lei Kong, Yong-Sheng Xie, Xu-Dong Ma, Yan Huang, Xi-Fu Shang   +4 more
doaj   +1 more source