Results 21 to 30 of about 87,840 (204)
Frontiers in Cell and Developmental Biology, 2022 Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis (OA), a prevalent progressive degenerative joint disease that causes debilitating pain.
Winni Gao +7 more
doaj +1 more source
Toward New Assessment of Knee Cartilage Degeneration
CARTILAGE, 2022 Objective Assessment of human joint cartilage is a crucial tool to detect and diagnose pathological conditions. This exploratory study developed a workflow for 3D modeling of cartilage and bone based on multimodal imaging. New evaluation metrics were created and, a unique set of data was gathered from healthy controls and patients with clinically ...
Romain Aubonnet +10 more
openaire +2 more sources
Nature Communications, 2022 This study demonstrates a role of cholesterol metabolism-related gene, Lrp3, in cartilage degeneration and osteoarthritis pathogenesis. LRP3 positively regulates cartilage extracellular matrix metabolism by targeting syndecan-4 via Ras signalling ...
Chenxi Cao +15 more
doaj +1 more source
Osteoarthritis and Cartilage Open, 2023 Objective: We previously reported how treadmill exercise can suppress cartilage degeneration. Here, we examined the changes in macrophage dynamics in knee osteoarthritis (OA) during treadmill exercise and the effect of macrophage depletion.
Yuichiro Oka +6 more
doaj +1 more source
A review of the differences between normal and osteoarthritis articular cartilage in human knee and ankle joints [PDF]
, 2009 Background: Osteoarthritis (OA) is the most common joint disease yet its pathophysiology is still poorly understood. It is more prevalent in some lower limb joints than others; in particular the knee is more commonly affected than the ankle.
Beeson, Paul +2 more
core +1 more source
Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. [PDF]
, 2016 BackgroundOne potential mechanism for early superficial cartilage wear in normal joints is alteration of the lubricant content and quality of synovial fluid.
Chen, Albert C +10 more
core +1 more source
Journal of Orthopaedics and Traumatology, 2021 Purpose Degeneration of the cartilage after anterior cruciate ligament reconstruction (ACL-R) is known, and further deterioration can be expected in patients with tunnel malplacement or partial meniscal resection.
Kathleen Andrä +7 more
doaj +1 more source
Sex-dependent variation in cartilage adaptation: from degeneration to regeneration
Biology of Sex Differences, 2023 Highlights Evidence indicates males and females respond differently to cartilage degeneration and regeneration. Few review articles available provide comprehensive information referencing clinical and laboratory research.
Jhanvee Patel +4 more
doaj +1 more source
Post-traumatic osteoarthritis in mice following mechanical injury to the synovial joint [PDF]
, 2017 We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response to mechanical injury.
Chinzei, Nobuaki +7 more
core +3 more sources
Journal of Orthopaedic Translation, 2022 Objective: The treatment of cartilage lesions has always been a difficult problem. Although cartilage tissue engineering provides alternative treatment options for cartilage lesions, biodegradable tissue engineering scaffolds have limitations.
Zhiguo Yuan +7 more
doaj +1 more source