Results 1 to 10 of about 55,407 (117)

Cartilage degeneration is associated with activation of the PI3K/AKT signaling pathway in a growing rat experimental model of developmental trochlear dysplasia

Journal of Advanced Research, 2022
Introduction: Trochlear dysplasia is a commonly encountered lower extremity deformity in humans. However, the molecular mechanism of cartilage degeneration in trochlear dysplasia is unclear thus far. Objectives: The PI3K/AKT signaling pathway is known to
Fei Wang, Xunkai Feng, Jinghui Niu
exaly   +3 more sources

Deficiency of the m⁶A reader IGF2BP2 mediates cellular senescence of chondrocytes and triggers cartilage degeneration. [PDF]

Cell Mol Life Sci
Summary Accumulating evidence has identified N6-methyladenosine (m6A) regulation in the progression of age-related diseases. However, whether the m6A reader protein IGF2BP2 affects the occurrence of cartilage degeneration is still unknown.
Shen ZH, Li XR, Lu J, Liu PL, He SH, Deng QS, Wang A, Zhang R, Tao SC, Guo SC.   +9 more
europepmc   +2 more sources

Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis. [PDF]

Front Cell Dev Biol
Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degradation of the ECM and cartilage degeneration. Articular cartilage is maintained by chondrocytes, which secrete the ECM, making the stability of these cells ...
Mei J, Xiao N, Xi Y, Chen X, Zha X, Cui L, Yan F, Xue R, Wang Y, Ma Y.   +9 more
europepmc   +2 more sources

Effects of Joint Immobilization and Treadmill Exercise on Articular Cartilage After ACL Reconstruction in Rats

Orthopaedic Journal of Sports Medicine, 2022
Background: The development of osteoarthritis after anterior cruciate ligament (ACL) reconstruction (ACLR) is an important issue. However, the appropriate rehabilitation protocol to prevent cartilage degeneration due to postoperative osteoarthritis is ...
Akinori Kaneguchi PT, PhD, Junya Ozawa PT, PhD, Kaoru Yamaoka MD, PhD   +2 more
doaj   +1 more source

Application of quantitative T1, T2 and T2* mapping magnetic resonance imaging in cartilage degeneration of the shoulder joint

Scientific Reports, 2023
To investigate and compare the values of 3.0 T MRI T1, T2 and T2* mapping quantification techniques in evaluating cartilage degeneration of the shoulder joint.
Guijuan Cao, Shubo Gao, Bin Xiong
doaj   +1 more source

Morphological and mechanical alterations in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs

Frontiers in Bioengineering and Biotechnology, 2023
Objectives: This study aimed to investigate the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs.Materials and methods: Hip joints of guinea pigs were investigated at 1,
Jiazi Gao, Pengling Ren, He Gong
doaj   +1 more source

Association of Postoperative Lateral Meniscal Extrusion With Cartilage Degeneration on Magnetic Resonance Imaging After Discoid Lateral Meniscus Reshaping Surgery

Orthopaedic Journal of Sports Medicine, 2022
Background: Although arthroscopic reshaping surgery for a discoid lateral meniscus (DLM) has good clinical results, it cannot completely prevent degeneration. The degree of DLM extrusion associated with degenerative changes is unclear. Purpose/Hypothesis:
Kazuya Nishino MD, Yusuke Hashimoto MD, PhD, Ken Iida MD, Yohei Nishida MD, Shinya Yamasaki MD, PhD, Hiroaki Nakamura MD, PhD   +5 more
doaj   +1 more source

Early patellofemoral articular cartilage degeneration in a rat model of patellar instability is associated with activation of the NF-κB signaling pathway

BMC Musculoskeletal Disorders, 2021
Background Patellar instability (PI) often increases the possibility of lateral patellar dislocation and early osteoarthritis. The molecular mechanism of early articular cartilage degeneration during patellofemoral osteoarthritis (PFOA) still requires ...
Wei Lin, Huijun Kang, Yike Dai, Yingzhen Niu, Guangmin Yang, Jinghui Niu, Ming Li, Fei Wang   +7 more
doaj   +1 more source

Comparison of properties determined using electromechanical assessment (Arthro-BST™) with macroscopic and histological properties in symptomatic human articular cartilage of the hip

Arthritis Research & Therapy, 2021
Background Cartilage degeneration is assessed using various methods. Although macroscopic evaluation can directly measure cartilage degeneration, it cannot accurately assess cartilage properties.
Taku Ukai, Masato Sato, Shiho Wasai, Takumi Takahashi, Haruka Omura, Masahiko Watanabe   +5 more
doaj   +1 more source

Preoperative flexion contracture is a predisposing factor for cartilage degeneration at the patellofemoral joint after open wedge high tibial osteotomy

Knee Surgery & Related Research, 2020
Purpose The purpose of the study was to determine the effect of cartilage degeneration at the patellofemoral joint on clinical outcomes after open wedge high tibial osteotomy and to investigate the predisposing factors for progressive patellofemoral ...
Shuhei Otsuki, Kuniaki Ikeda, Hitoshi Wakama, Nobuhiro Okuno, Yoshinori Okamoto, Tomohiro Okayoshi, Yuki Miyamoto, Masashi Neo   +7 more
doaj   +1 more source