Results 1 to 10 of about 87,840 (204)

Cartilage degeneration is associated with activation of the PI3K/AKT signaling pathway in a growing rat experimental model of developmental trochlear dysplasia

Journal of Advanced Research, 2022
Introduction: Trochlear dysplasia is a commonly encountered lower extremity deformity in humans. However, the molecular mechanism of cartilage degeneration in trochlear dysplasia is unclear thus far. Objectives: The PI3K/AKT signaling pathway is known to
Xunkai Feng, Fei Wang
exaly   +3 more sources

Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis [PDF]

Frontiers in Cell and Developmental Biology
Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degradation of the ECM and cartilage degeneration. Articular cartilage is maintained by chondrocytes, which secrete the ECM, making the stability of these cells ...
Jiahua Mei, Niqin Xiao, Yujiang Xi, Xin Chen, Xuezhi Zha, Lili Cui, Fei Yan, Rui Xue, Yongsen Wang, Yunshu Ma, Yunshu Ma, Yunshu Ma   +11 more
doaj   +2 more sources

The clinical application value of 3.0T magnetic resonance T2 mapping imaging in evaluating the degree of acetabular cartilage degeneration in joint replacement surgery running title: MRI and acetabular cartilage degeneration [PDF]

Journal of Orthopaedic Surgery and Research
Background To explore and compare the values of 3.0T magnetic resonance imaging (MRI) T2 mapping in evaluating the degree of acetabular cartilage degeneration in hip replacement surgery.
Xiang Peng, An-min Xie, Hua-gang Fan, Hong-liang Zhu, Di Yang, De-en Wan, Fei He, Chong Luo, Hao Li, Feng Shuang   +9 more
doaj   +2 more sources

Subchondral Cellular Density Decreases with Increasing Grade of Cartilage Degeneration in Knee Osteoarthritis – An Ex vivo Histopathological Analysis [PDF]

Journal of Orthopaedic Case Reports
Introduction: Subchondral milieu has been the region of interest in recent clinical trials demonstrating it as an effective treatment focus in knee osteoarthritis (OA).
Sathish Muthu, Ragavi Kandasamy, Suryaprabha Palanisamy, Arun Anand Palaniappan   +3 more
doaj   +2 more sources

Loss of mechanical stress induces synovitis, fibrosis and articular cartilage degeneration via distinct synovial cell subsets [PDF]

Scientific Reports
Joint function is impaired by disuse, as well as overuse. However, the underlying mechanisms remain unclear. Here, we elucidate the mechanisms of synovial and cartilage changes using a minimized mechanical stress (MMS) mouse model by combining knee joint
Hisatoshi Ishikura, Hiroyuki Okada, Yota Kin, Ryota Chijimatsu, Junya Higuchi, Junya Miyahara, Naohiro Tachibana, Kosei Nagata, Asuka Terashima, Fumiko Yano, Yasunori Omata, Masahide Seki, Yutaka Suzuki, Roland Baron, Sakae Tanaka, Taku Saito   +15 more
doaj   +2 more sources

Effects of Joint Immobilization and Treadmill Exercise on Articular Cartilage After ACL Reconstruction in Rats

Orthopaedic Journal of Sports Medicine, 2022
Background: The development of osteoarthritis after anterior cruciate ligament (ACL) reconstruction (ACLR) is an important issue. However, the appropriate rehabilitation protocol to prevent cartilage degeneration due to postoperative osteoarthritis is ...
Akinori Kaneguchi PT, PhD, Junya Ozawa PT, PhD, Kaoru Yamaoka MD, PhD   +2 more
doaj   +1 more source

Application of quantitative T1, T2 and T2* mapping magnetic resonance imaging in cartilage degeneration of the shoulder joint

Scientific Reports, 2023
To investigate and compare the values of 3.0 T MRI T1, T2 and T2* mapping quantification techniques in evaluating cartilage degeneration of the shoulder joint.
Guijuan Cao, Shubo Gao, Bin Xiong
doaj   +1 more source

Morphological and mechanical alterations in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs

Frontiers in Bioengineering and Biotechnology, 2023
Objectives: This study aimed to investigate the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs.Materials and methods: Hip joints of guinea pigs were investigated at 1,
Jiazi Gao, Pengling Ren, He Gong
doaj   +1 more source

Association of Postoperative Lateral Meniscal Extrusion With Cartilage Degeneration on Magnetic Resonance Imaging After Discoid Lateral Meniscus Reshaping Surgery

Orthopaedic Journal of Sports Medicine, 2022
Background: Although arthroscopic reshaping surgery for a discoid lateral meniscus (DLM) has good clinical results, it cannot completely prevent degeneration. The degree of DLM extrusion associated with degenerative changes is unclear. Purpose/Hypothesis:
Kazuya Nishino MD, Yusuke Hashimoto MD, PhD, Ken Iida MD, Yohei Nishida MD, Shinya Yamasaki MD, PhD, Hiroaki Nakamura MD, PhD   +5 more
doaj   +1 more source

Early patellofemoral articular cartilage degeneration in a rat model of patellar instability is associated with activation of the NF-κB signaling pathway

BMC Musculoskeletal Disorders, 2021
Background Patellar instability (PI) often increases the possibility of lateral patellar dislocation and early osteoarthritis. The molecular mechanism of early articular cartilage degeneration during patellofemoral osteoarthritis (PFOA) still requires ...
Wei Lin, Huijun Kang, Yike Dai, Yingzhen Niu, Guangmin Yang, Jinghui Niu, Ming Li, Fei Wang   +7 more
doaj   +1 more source