Results 1 to 10 of about 9,103,182 (195)
The role of TGF-β2 in cartilage development and diseases
Bone & Joint Research, 2021 Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its ...
Mengmeng Duan +3 more
doaj +5 more sources
Matrix Biology, 2018 Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human body including bearing loads in articular joints and intervertebral discs, providing joint lubrication, forming the external ears and nose, supporting the trachea, and forming the long bones during development and growth.
Yamini Krishnan, Alan J. Grodzinsky
semanticscholar +7 more sources
Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2021 When suffering from osteoarthritis (OA), articular cartilage homeostasis is out of balance and the living quality declines. The treatment of knee OA has always been an unsolved problem in the world. At present, symptomatic treatment is mainly adopted for
Zongmian Song +7 more
doaj +4 more sources
The Effects of Crocin on Bone and Cartilage Diseases [PDF]
Frontiers in Pharmacology, 2022 Crocin, the main biologically active carotenoid of saffron, generally is derived from the dried trifid stigma of Crocus sativus L. Many studies have demonstrated that crocin has several therapeutic effects on biological systems through its anti-oxidant ...
Shayan Vafaei +3 more
semanticscholar +4 more sources
The protective activity of genistein against bone and cartilage diseases
Frontiers in Pharmacology, 2022 Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and bone/cartilage protection.
Zhenyu Wu, Zhenyu Wu, Luying Liu
doaj +2 more sources
Cartilage organoids for cartilage development and cartilage-associated disease modeling
Frontiers in Cell and Developmental Biology, 2023 Cartilage organoids have emerged as powerful modelling technology for recapitulation of joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage-associated diseases.
Weiping Lin +8 more
doaj +3 more sources
The regulatory activities of MALAT1 in the development of bone and cartilage diseases
Frontiers in Endocrinology, 2022 Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities.
Di Zhang, Jinhua Xue, Fang Peng
doaj +2 more sources
Melatonin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-related Diseases [PDF]
Aging and disease, 2021 Cartilage is a relatively simple connective tissue that plays a variety of roles in the human body, including joint support and protection, load bearing of the intervertebral discs, joint lubrication, formation of the external structure of the ears and ...
W. Xie +7 more
semanticscholar +4 more sources
A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system
International Journal of Nanomedicine, 2018 Shaowei Wang,1 Xiaochun Wei,1 Xiaojuan Sun,1 Chongwei Chen,1 Jingming Zhou,2 Ge Zhang,3 Heng Wu,3 Baosheng Guo,3 Lei Wei1,2 1Department of Orthopaedics, The 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Department of Orthopaedics ...
Wang S +8 more
doaj +2 more sources
Strategies for Articular Cartilage Repair and Regeneration
Frontiers in Bioengineering and Biotechnology, 2021 Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis.
Yanxi Liu +3 more
doaj +2 more sources