Cartilage organoids for cartilage development and cartilage-associated disease modeling [PDF]
Frontiers in Cell and Developmental Biology, 2023 Cartilage organoids have emerged as powerful modelling technology for recapitulation of joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage-associated diseases.
Weiping Lin +8 more
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MSC-EV therapy for bone/cartilage diseases [PDF]
Bone Reports, 2022 Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs) released by MSCs play an important role in their therapeutic activities. EVs contain a variety of
Joe Kodama +2 more
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Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2021 When suffering from osteoarthritis (OA), articular cartilage homeostasis is out of balance and the living quality declines. The treatment of knee OA has always been an unsolved problem in the world. At present, symptomatic treatment is mainly adopted for
Zongmian Song +7 more
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The protective activity of genistein against bone and cartilage diseases [PDF]
Frontiers in Pharmacology, 2022 Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and bone/cartilage protection.
Zhenyu Wu, Zhenyu Wu, Luying Liu
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The regulatory activities of MALAT1 in the development of bone and cartilage diseases [PDF]
Frontiers in Endocrinology, 2022 Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities.
Di Zhang, Jinhua Xue, Fang Peng
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The role of TGF-β2 in cartilage development and diseases
Bone & Joint Research, 2021 Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its ...
Mengmeng Duan +3 more
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A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system [PDF]
International Journal of Nanomedicine, 2018 Shaowei Wang,1 Xiaochun Wei,1 Xiaojuan Sun,1 Chongwei Chen,1 Jingming Zhou,2 Ge Zhang,3 Heng Wu,3 Baosheng Guo,3 Lei Wei1,2 1Department of Orthopaedics, The 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Department of Orthopaedics ...
Wang S +8 more
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Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications [PDF]
Small ScienceWith the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health.
Yao Wang +3 more
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Recent Progress in 3D Printing of Elastic and High-Strength Hydrogels for the Treatment of Osteochondral and Cartilage Diseases. [PDF]
Front Bioeng Biotechnol, 2020 Dai W, Sun M, Leng X, Hu X, Ao Y.
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Role of Tyrosine Kinase Inhibitors in Modulating Chondrocyte Activity and Cartilage Diseases. [PDF]
J Bone MetabHadid KA, Zaki MK, Alassaf FA, Abed MN.
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