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MSC-EV therapy for bone/cartilage diseases [PDF]
Bone Reports, 2022 Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs) released by MSCs play an important role in their therapeutic activities. EVs contain a variety of
Joe Kodama +2 more
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The protective activity of genistein against bone and cartilage diseases [PDF]
Frontiers in Pharmacology, 2022 Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and bone/cartilage protection.
Zhenyu Wu, Zhenyu Wu, Luying Liu
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Cartilage organoids for cartilage development and cartilage-associated disease modeling
Frontiers in Cell and Developmental Biology, 2023 Cartilage organoids have emerged as powerful modelling technology for recapitulation of joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage-associated diseases.
Weiping Lin +8 more
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The regulatory activities of MALAT1 in the development of bone and cartilage diseases [PDF]
Frontiers in Endocrinology, 2022 Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities.
Di Zhang, Jinhua Xue, Fang Peng
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Matrix Biol, 2018 Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human body including bearing loads in articular joints and intervertebral discs, providing joint lubrication, forming the external ears and nose, supporting the trachea, and forming the long bones during development and growth.
Krishnan Y, Grodzinsky AJ.
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Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2021 When suffering from osteoarthritis (OA), articular cartilage homeostasis is out of balance and the living quality declines. The treatment of knee OA has always been an unsolved problem in the world. At present, symptomatic treatment is mainly adopted for
Zongmian Song +7 more
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A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system [PDF]
International Journal of Nanomedicine, 2018 Shaowei Wang,1 Xiaochun Wei,1 Xiaojuan Sun,1 Chongwei Chen,1 Jingming Zhou,2 Ge Zhang,3 Heng Wu,3 Baosheng Guo,3 Lei Wei1,2 1Department of Orthopaedics, The 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Department of Orthopaedics ...
Wang S +8 more
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The role of TGF-β2 in cartilage development and diseases
Bone & Joint Research, 2021 Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its ...
Mengmeng Duan +3 more
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PTPN11 in cartilage development, adult homeostasis, and diseases
Bone ResearchThe SH2 domain-containing protein tyrosine phosphatase 2 (SHP2, also known as PTP2C), encoded by PTPN11, is ubiquitously expressed and has context-specific effects.
Wentian Yang, Véronique Lefebvre
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Stem Cells in Cartilage Diseases and Repair 2018 [PDF]
Stem Cells International, 2018 Jianying Zhang +4 more
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