Results 21 to 30 of about 108,199 (280)

High efficiency transfection of embryonic limb mesenchyme with plasmid DNA using square wave pulse electroporation and sucrose buffer

BioTechniques, 2014
Micromass cultures of primary embryonic limb mesenchyme are a valuable model system for studying cartilage formation in vitro. However, high efficiency introduction of plasmid DNA into this hard-to-transfect cell type typically results in considerable ...
Brent E. Bobick, Peter G. Alexander, Rocky S. Tuan   +2 more
doaj   +1 more source

Strategies for Articular Cartilage Repair and Regeneration

Frontiers in Bioengineering and Biotechnology, 2021
Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis.
Yanxi Liu, Karan M. Shah, Jian Luo, Jian Luo   +3 more
doaj   +1 more source

Copper-Containing Alloy as Immunoregulatory Material in Bone Regeneration via Mitochondrial Oxidative Stress

Frontiers in Bioengineering and Biotechnology, 2021
In the mammalian skeletal system, osteogenesis and angiogenesis are closely linked by type H vessels during bone regeneration and repair. Our previous studies confirmed the promotion of these processes by copper-containing metal (CCM) in vitro and in ...
Daorong Xu, Daorong Xu, Jikun Qian, Jikun Qian, Xin Guan, Xin Guan, Ling Ren, Kaifan Yang, Kaifan Yang, Xuan Huang, Shuyuan Zhang, Yu Chai, Yu Chai, Xiaohu Wu, Xiaohu Wu, Hangtian Wu, Hangtian Wu, Xianrong Zhang, Xianrong Zhang, Ke Yang, Bin Yu, Bin Yu   +21 more
doaj   +1 more source

DEGENERATIVE ARTICULAR CARTILAGE DISEASE, OSTEOARTHROSIS

EPRA International Journal of Multidisciplinary Research (IJMR), 2023
Introduction: Osteoarthrosis (OA), degenerative articular cartilage disease is a chronic inflammatory arthropathy involving joint elements (subchondral bone, synovial membrane, hyaline cartilage and others). It is due to a disorder in the regulation between degradation and synthesis of the extracellular matrix of cartilage, involving bone and synovial ...
null Bryam Esteban Coello García, null Angel Patricio Fajardo Zhao, null Byron Xavier Cabrera Castillo, null Holger Xavier Rojas Espinoza, null Brian Andrés Serpa Ocampo, null Karina Noemí Contreras García   +5 more
openaire   +1 more source

Sex-dependent variation in cartilage adaptation: from degeneration to regeneration

Biology of Sex Differences, 2023
Highlights Evidence indicates males and females respond differently to cartilage degeneration and regeneration. Few review articles available provide comprehensive information referencing clinical and laboratory research.
Jhanvee Patel, Song Chen, Torey Katzmeyer, Yixuan Amy Pei, Ming Pei   +4 more
doaj   +1 more source

Use of Exogenous Hyaluronic Acid for the Treatment of Patellar Chondropathy– A Six-Month Randomized Controlled Trial [PDF]

Revista Brasileira de Ortopedia
Objective To evaluate the clinical and radiological benefits of intra-articular exogenous hyaluronic acid for the treatment of chondral patellar injury. Method Randomized clinical trial with 70 patients divided into 2 groups: those submitted to physical
Diego Costa Astur, Felipe Berteli Angelini, Marcelo Abdulchlek Santos, Gustavo Gonçalves Arliani, Paulo Santoro Belangero, Moisés Cohen   +5 more
doaj   +3 more sources

Effects of the Leptin-Mediated MAPK/ERK Signaling Pathway on Collagen II Expression in Knee Cartilage of Newborn Male Mice from Obese Maternal Offspring

Biomolecules, 2022
Epidemiological data suggest that various noncommunicable diseases develop as a result of altered maternal metabolic and physiological status due to exposure to several adverse factors during pregnancy. However, evidence for intrauterine exposure factors
Wenji Wang, Jialing Zhang, Yu Huo, Yuanzheng Zheng, Yonghao Gui   +4 more
doaj   +1 more source

Gold Nanomaterials and Bone/Cartilage Tissue Engineering: Biomedical Applications and Molecular Mechanisms

Frontiers in Chemistry, 2021
Recently, as our population increasingly ages with more pressure on bone and cartilage diseases, bone/cartilage tissue engineering (TE) have emerged as a potential alternative therapeutic technique accompanied by the rapid development of materials ...
Yifeng Shi, Yifeng Shi, Yifeng Shi, Xuyao Han, Shuang Pan, Yuhao Wu, Yuhan Jiang, Jinghao Lin, Yihuang Chen, Haiming Jin, Haiming Jin   +10 more
doaj   +1 more source

Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications

Frontiers in Cell and Developmental Biology, 2021
The involvement of histone modifications in cartilage development, pathology and regeneration is becoming increasingly evident. Understanding the molecular mechanisms and consequences of histone modification enzymes in cartilage development, homeostasis ...
Chao Wan, Chao Wan, Chao Wan, Fengjie Zhang, Fengjie Zhang, Fengjie Zhang, Hanyu Yao, Hanyu Yao, Hanyu Yao, Haitao Li, Rocky S. Tuan, Rocky S. Tuan, Rocky S. Tuan   +12 more
doaj   +1 more source

SOX9 in cartilage development and disease

Current Opinion in Cell Biology, 2019
SOX9 is a pivotal transcription factor in chondrocytes, a lineage essential in skeletogenesis. Its mandatory role in transactivating many cartilage-specific genes is well established, whereas its pioneer role in lineage specification, which along with transactivation defines master transcription factors, remains to be better defined.
Véronique, Lefebvre, Marco, Angelozzi, Abdul, Haseeb   +2 more
openaire   +3 more sources