Results 11 to 20 of about 147,512 (341)

Cell therapy for cartilage repair [PDF]

Emerging Topics in Life Sciences, 2021
Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations,
Charlotte H. Hulme, Jade Perry, Helen S. McCarthy, Karina T. Wright, Martyn Snow, Claire Mennan, Sally Roberts   +6 more
openaire   +3 more sources

Patellofemoral Cartilage Repair [PDF]

Current Reviews in Musculoskeletal Medicine, 2018
This review provides an overview of well-established and newly developed cartilage repair techniques for cartilage defects in the patellofemoral joint (PFJ). An algorithm will be presented for approaching cartilage defects considering the distinct anatomy of both the patellar and trochlear articular surfaces.Recent studies on cartilage repair in the ...
Mestriner, Alexandre Barbieri, Ackermann, Jakob, Gomoll, Andreas H.   +2 more
openaire   +3 more sources

Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures [PDF]

, 2013
The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise.
Blitterswijk, C.A. van, Georgi, N., Karperien, H.B.J., Leijten, J.C.H., Wu, L.   +4 more
core   +3 more sources

Arthroscopic Treatment of Cartilage Lesions With Microfracture and BST-CarGel

Arthroscopy Techniques, 2014
Bone marrow stimulation techniques for the treatment of articular cartilage defects such as microfracture so far have solely reproduced mechanically inferior fibrous cartilage tissue, which might result in unsatisfactory clinical results at midterm ...
Matthias R. Steinwachs, M.D., Bernhard Waibl, M.D., Marcus Mumme, M.D.   +2 more
doaj   +1 more source

Enhanced Tissue Integration During Cartilage RepairIn VitroCan Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge [PDF]

, 2009
Objective: Experimental wounding of articular cartilage results in cell death at the lesion edge. The objective of this study was to investigate whether inhibition of this cell death results in enhanced integrative cartilage repair.
Archer, Charles W., Burdon, Drew, Duance, Victor C., Gilbert, Sophie J., Gonzalez, Lee G., Khan, Ilyas M., Singhrao, Simarjit Kaur, Thomson, Brian M.   +7 more
core   +1 more source

Histological Analysis of Failed Cartilage Repair after Marrow Stimulation for the Treatment of Large Cartilage Defect in Medial Compartmental Osteoarthritis of the Knee [PDF]

, 2013
Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human ...
Abe, Nobuhiro, Furumatsu, Takayuki, Miyazawa, Shinichi, Ozaki, Toshifumi, Sakata, Kenichiro, Sakoma, Yoshimasa   +5 more
core   +1 more source

Preclinical Studies for Cartilage Repair [PDF]

CARTILAGE, 2011
Investigational devices for articular cartilage repair or replacement are considered to be significant risk devices by regulatory bodies. Therefore animal models are needed to provide proof of efficacy and safety prior to clinical testing. The financial commitment and regulatory steps needed to bring a new technology to clinical use can be major ...
Hurtig, Mark B., Buschmann, Michael D., Fortier, Lisa A., Hoemann, Caroline D., Hunziker, Ernst B., Jurvelin, Jukka S., Mainil-Varlet, Pierre, McIlwraith, C. Wayne, Sah, Robert L., Whiteside, Robert A.   +9 more
openaire   +2 more sources

Exosomes in cartilage microenvironment regulation and cartilage repair. [PDF]

Front Cell Dev Biol
Osteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology is defined by the progressive degradation of articular cartilage, formation of bone spurs, and synovial inflammation, resulting in pain, joint function limitations, and substantial societal and familial burdens.
Longfei H, Wenyuan H, Weihua F, Peng P, Sun L, Kun L, Mincong H, Fan Y, Wei H, Qiushi W.   +9 more
europepmc   +4 more sources

Relationship Between Quantitative MRI Biomarkers and Patient-Reported Outcome Measures After Cartilage Repair Surgery: A Systematic Review. [PDF]

, 2018
Background:Treatment of articular cartilage injuries remains a clinical challenge, and the optimal tools to monitor and predict clinical outcomes are unclear.
Cole, Brian J, Cotter, Eric, Davey, Annabelle, Lansdown, Drew A, Wang, Kevin   +4 more
core   +1 more source

Signaling Pathways in Cartilage Repair [PDF]

International Journal of Molecular Sciences, 2014
In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine balance between anabolic and catabolic activities. In ageing, degenerative joint diseases and traumatic injuries of cartilage, a loss of homeostatic conditions and an up-regulation of catabolic pathways occur.
MARIANI, ERMINIA, Pulsatelli, Lia, Facchini, Andrea   +2 more
openaire   +2 more sources