Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases [PDF]
, 2013 AIM: Autologous chondrocyte implantation (ACI) is used worldwide for the treatment of cartilage defects. This study has aimed to assess for the first time the cells that are contained within human ACI repair tissues several years post-treatment.
Banerjee, R +5 more
core +2 more sources
Improved diagnosis of tibiofemoral cartilage defects on MRI images using deep learning
Journal of Cartilage & Joint Preservation, 2021 Introduction: MRI is the modality of choice for cartilage imaging, however, its diagnostic performance is variable. Objectives: We aimed to evaluate whether deep learning can be utilized to accurately identify cartilage defects when applied to the ...
Gergo Merkely, M.D. +7 more
doaj
Gene Therapy for Cartilage Repair [PDF]
CARTILAGE, 2011 The concept of using gene transfer strategies for cartilage repair originates from the idea of transferring genes encoding therapeutic factors into the repair tissue, resulting in a temporarily and spatially defined delivery of therapeutic molecules to sites of cartilage damage.
Magali Cucchiarini +2 more
openaire +3 more sources
A review of the differences between normal and osteoarthritis articular cartilage in human knee and ankle joints [PDF]
, 2009 Background: Osteoarthritis (OA) is the most common joint disease yet its pathophysiology is still poorly understood. It is more prevalent in some lower limb joints than others; in particular the knee is more commonly affected than the ankle.
Beeson, Paul +2 more
core +1 more source
Journal of Cartilage & Joint Preservation, 2023 Introduction: Cartilage restoration in the middle-aged population (40-60 years) is understudied. Objectives: The purpose of this study is to report the clinical outcomes and satisfaction of patients over the age of 40 years old who underwent autologous ...
Liana Leja, Tom Minas
doaj
A primer in cartilage repair [PDF]
The Journal of Bone and Joint Surgery. British volume, 2012 Hyaline articular cartilage has been known to be a troublesome tissue to repair once damaged. Since the introduction of autologous chondrocyte implantation (ACI) in 1994, a renewed interest in the field of cartilage repair with new repair techniques and the hope for products that are regenerative have blossomed.
openaire +3 more sources
The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. [PDF]
, 2013 Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments.
Maldonado, Maricela, Nam, Jin
core +3 more sources
Cartilage repair in the degenerative ageing knee: A narrative review and analysis
Acta Orthopaedica, 2016 Background and purpose — Cartilage damage can develop due to trauma, resulting in focal chondral or osteochondral defects, or as more diffuse loss of cartilage in a generalized organ disease such as osteoarthritis.
Mats Brittberg +5 more
doaj +1 more source
Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair [PDF]
, 2016 Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area ...
Ali Mobasheri +8 more
core +2 more sources
Cellular senescence in aging and osteoarthritis: Implications for cartilage repair
Acta Orthopaedica, 2016 — It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis.
Wei Seong Toh +8 more
doaj +1 more source