Results 31 to 40 of about 1,184 (187)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A critical discourse analysis of selected animated cartoons of African origin

Cogent Arts & Humanities
Animated cartoons provide entertainment for children. In addition, they serve as agents of socialization. The content of animated cartoons is capable of changing, molding and influencing the thoughts and actions of children.
Joanita Naa Shika Okuley, Christiana Hammond, Albert Agbesi Wornyo, Abena Abokoma Asemanyi   +3 more
doaj   +1 more source

Disraeli and “One Nation” in British cartoons, 1914-2016

Revue Française de Civilisation Britannique, 2023
This paper analyzes the cartoons featuring Benjamin Disraeli after his death and the concept of “One Nation”. It shows that Disraeli remained through the 20th century a persona which British cartoonists recurringly made use of, although Churchill, and to
Philippe Vervaecke
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Hate speech or legitimate satire? Drawing the line in cartoons

Hermes, 2023
Controversial cartoons appearing in contemporary news and social media are periodically denounced by consumers for hate speech, and argued over in blogs, reader comments and news articles.
Elizabeth Swain
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Cartoon-based message strategies on vaccination in Romania and engagement behavior. A multimodal approach.

Romanian Journal of Communications and Public Relations
This study investigates the influence of Romanian cartoons related to COVID-19 vaccination on online engagement. Humor has been employed by (inter)national authorities in order to simplify complex issues and to encourage positive attitudes and behaviors
Camelia Cmeciu
doaj   +1 more source

Cultural Awareness in Pre-Service Early Childhood Teacher Training: A Catalogue of British Cultural Elements in Peppa Pig

Education Sciences, 2023
Foreign language teaching should integrate the culture embodied in the target language. However, raising cultural awareness does not systematically produce the intended effects when considered an integral component in the teaching context.
José Luis Estrada-Chichón, Roberto Sánchez-Cabrero   +1 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source