Results 71 to 80 of about 45,815 (295)
Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
Advanced Science, EarlyView.MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases
Advanced Science, EarlyView.There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia +7 more
wiley +1 more source
Animation from a legitimate perspective
مجلة كلية التربية للبنات, 2019 This study aims at investigating the partial Islamic rules of preparing and distributing cartoons in order to issue an overall Islamic rul. To reach an end, descriptive and analytical approaches are adopted to clarify the nature of cartoons and other ...
ساجدة طه محمود
doaj
The use of political cartoons during popular protests: the case of the 2011 Tunisia uprising
Journal of English Studies, 2017 This study investigates the use of political cartoons in the Tunisian context during its transitory phase in the aftermath of the 2011 uprising. It explores how political cartoons were used to critically reflect the socioeconomic and geopolitical ...
Chaker Ali Mhamdi
doaj +1 more source
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Animator-producer Paul Houlton Terry has been portrayed as having little passion for the animation he produced and being more concerned with making a profit
Hamonic, Wynn
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Advanced Science, EarlyView.Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun +11 more
wiley +1 more source
European Journal of Geography, 2013 The comics and related arts (cartoons, graffiti, illustrated posters and signs) have always played an important role in shaping public protests. From the French Revolution to the recent Arab Spring revolutionary wave of demonstrations and protests ...
Mary TOTRY, Arnon MEDZINI
doaj +2 more sources
A Hermeneutical Study of Mass Media Cartoons in The Political Year of 2024
NirmanaMass media cartoons are works of visual communication that have the 'task' of conveying opinions or criticism of socio-political discourse with a touch of humor.
I Wayan Nuriarta +1 more
doaj +1 more source
Printed page of cartoons, scientist, writer and gentleman [picture] /
, 1900 Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Print of original drawings.; Title devised by cataloguer.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.pic ...
Cross, Stan, 1888-1977.
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Advanced Science, EarlyView.SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng +18 more
wiley +1 more source