Results 51 to 60 of about 182,393 (338)

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

Angewandte Chemie, EarlyView.
Our study introduces TL‐alkyne as an innovative tool for bio‐orthogonal labeling of endogenous XPB in live cells, facilitating the creation of a cell‐based imaging HCS assay. This platform not only enabled the identification of pelitinib as a novel XPB inhibitor but also demonstrated its potential to improve cancer treatment through synergistic effects
Shuqi Li, Hong‐Rui Zhang, Yang Yang, Ben Chi‐Bun Ko, Jin Shang, Haijun Guo, Dan Yang, Mankin Wong, Ricky Wing‐Cheung Chan, Karen Ka‐Yan Kung, Qian Zhao   +10 more
wiley   +2 more sources

Basophil allergen threshold sensitivity to casein (casein‐specific CD‐sens) predicts allergic reactions at a milk challenge in most but not all patients

Immunity, Inflammation and Disease
Background The basophil activation test is an emerging clinical tool in the diagnosis of cow's milk allergy (CMA). The aim was to assess the association between the basophil allergen threshold sensitivity to the major milk protein casein (casein‐specific
Solveig Røisgård, Anna Nopp, Anna Lindam, SWITCH study group, Caroline A. Nilsson, Christina E. West   +5 more
doaj   +1 more source

Application of FT near spectroscopy for determination of true protein and casein in milk

Czech Journal of Animal Science, 2007
Our study deals with a possibility of determining true protein and casein in cow's, ewe's and goat's milk and in ewe's colostrums by FT NIR spectroscopy. Samples of milk were analysed by FT NIR in the reflectance mode with the transflectance cuvette. The
K. Šustová, J. Růžičková, J. Kuchtík   +2 more
doaj   +1 more source

Casein Proteins: Structural and Functional Aspects

, 2016
Mammalian milk is a complex fluid mixture of various proteins, minerals, and lipids, which play an important role in providing nutrition and immunity to the newborn.
M. Y. Bhat, T. Dar, Laishram RajendrakumarSingh   +2 more
semanticscholar   +1 more source

Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows’ milk

Nutrix Journal, 2015
BackgroundCows’ milk generally contains two types of β-casein, A1 and A2 types. Digestion of A1 type can yield the peptide β-casomorphin-7, which is implicated in adverse gastrointestinal effects of milk consumption, some of which resemble those in ...
Jianqin Sun, Leiming Xu, Xia Lu, Gregory W. Yelland, Jiayi Ni, A. Clarke   +5 more
semanticscholar   +1 more source

PLUS: Primary Layer for Universal Sensing Enabling Improved Immunocapture of Biomarkers in Clinical Scenarios

Advanced Healthcare Materials, EarlyView.
Primary Layer for Universal Sensing (PLUS), a universal coating for bioprobe immobilization across diverse substrates, is introduced. Unlike conventional methods, PLUS is directly grown from dopamine and avidin, creating a roughened surface with abundant biotin‐binding sites.
Nayoung Son, Chorok Byeon, Haejin Jeong, Hyeonha Jang, Jun Seok Park, Seonki Hong   +5 more
wiley   +1 more source

Milk lacking α-casein leads to permanent reduction in body size in mice.

PLoS ONE, 2011
The major physiological function of milk is the transport of amino acids, carbohydrates, lipids and minerals to mammalian offspring. Caseins, the major milk proteins, are secreted in the form of a micelle consisting of protein and calcium-phosphate.We ...
Andreas F Kolb, Reinhard C Huber, Simon G Lillico, Ailsa Carlisle, Claire J Robinson, Claire Neil, Linda Petrie, Dorte B Sorensen, I Anna S Olsson, C Bruce A Whitelaw   +9 more
doaj   +1 more source

Preparation of Casein Phosphopeptides from Casein Micelles by Ultrafiltration [PDF]

Bioscience, Biotechnology, and Biochemistry, 1995
Casein phosphopeptides (CPPs), which inhibit the precipitation of calcium phosphate in the intestines, were prepared as CPP-calcium phosphate complexes from casein micelles by the ultrafiltration method. The prepared CPPs hardly contained any other peptides, so there was no need to treat with active carbon to remove the bitter peptides.
Tomotada Ono, Tetsuo Ito, Toshihiko Ohotawa, Yasushi Takagi   +3 more
openaire   +3 more sources

Casein polymorphism heterogeneity influences casein micelle size in milk of individual cows.

Journal of Dairy Science, 2015
Milk samples from individual cows producing small (148-155 nm) or large (177-222 nm) casein micelles were selected to investigate the relationship between the individual casein proteins, specifically κ- and β-casein phenotypes, and casein micelle size ...
Li Day, Li Day, Roderick P.W. Williams, Don E. Otter, M. Augustin   +4 more
semanticscholar   +1 more source

Flippase‐Mediated Hybrid Vesicle Division

Advanced Materials, EarlyView.
The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′‐triphosphate consumption and flipping of 2‐dioleoyl‐sn‐glycero‐3‐phospho‐l‐serine lipids from the inner to the outer leaflet.
Paula De Dios Andres, Amalie Benfeldt Purup, Grégory Beaune, Jaakko V. I. Timonen, Joseph A. Lyons, Brigitte Städler   +5 more
wiley   +1 more source