Results 101 to 110 of about 43,177 (231)

Mitotic ER exit site dynamics: insights into blockade of secretion from the ER during mitosis

Molecular & Cellular Oncology, 2020
How ER exit sites disassemble during mitosis is not well understood. Transport ANd Golgi Organization 1 (TANGO1, also known as MIA3), a cargo receptor originally identified for collagens, acts as a hub for ER exit site disassembly under the control of ...
Miharu Maeda, Yukie Komatsu, Kota Saito
doaj   +1 more source

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, EarlyView.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

Table4_Evolution of casein kinase 1 and functional analysis of new doubletime mutants in Drosophila.DOCX

, 2022
Circadian clocks are timing devices that rhythmically adjust organism’s behavior, physiology, and metabolism to the 24-h day-night cycle. Eukaryotic circadian clocks rely on several interlocked transcription-translation feedback loops, where protein ...
Olga Bazalova (14256296), Jan Martinek (8519184), Ralf Stanewsky (264551), Vlastimil Smykal (193852), Astrid Giesecke (8069885), David Dolezel (6953867), Nirav Thakkar (14256293)   +6 more
core   +1 more source

CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

Nature Communications, 2019
In atherosclerotic plaques, transformation of macrophages into foam cells is a key step in initiating the inflammatory response. Here Fan et al. show that casein kinase 2-interacting protein-1 (CKIP-1) limits foam cell formation and atherosclerosis by ...
Jiao Fan, Lifeng Liu, Qingyan Liu, Yu Cui, Binwei Yao, Minghua Zhang, Yabing Gao, Yesheng Fu, Hongmiao Dai, Jingkun Pan, Ya Qiu, Cui Hua Liu, Fuchu He, Yu Wang, Lingqiang Zhang   +14 more
doaj   +1 more source

Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90

Cell Reports, 2019
Summary: The molecular chaperone Hsp90 stabilizes and activates client proteins. Co-chaperones and post-translational modifications tightly regulate Hsp90 function and consequently lead to activation of clients.
Rebecca A. Sager, Mark R. Woodford, Sarah J. Backe, Alan M. Makedon, Alexander J. Baker-Williams, Bryanna T. DiGregorio, David R. Loiselle, Timothy A. Haystead, Natasha E. Zachara, Chrisostomos Prodromou, Dimitra Bourboulia, Laura S. Schmidt, W. Marston Linehan, Gennady Bratslavsky, Mehdi Mollapour   +14 more
doaj   +1 more source

Convergent digestive adaptation to resource limitation in an insular lizard across a microgeographic archipelago

Journal of Animal Ecology, EarlyView.
Replicated mainland–islet populations of the Skyros wall lizard reveal consistent divergence in digestive physiology, including gut morphology, passage time, digestive efficiency and enzyme activity. These results show how ecological variation in resource availability can shape digestive performance across populations in insular environments.
Aikaterini Reppa, Foteini Paraskevopoulou, Kyriaki Papageorgiou, Giannis Tounias, Panayiota Santikou, Aristeidis Parmakelis, Efstratios D. Valakos, Panayiotis Pafilis, Kostas Sagonas   +8 more
wiley   +1 more source

Image8_Evolution of casein kinase 1 and functional analysis of new doubletime mutants in Drosophila.TIF

, 2022
Circadian clocks are timing devices that rhythmically adjust organism’s behavior, physiology, and metabolism to the 24-h day-night cycle. Eukaryotic circadian clocks rely on several interlocked transcription-translation feedback loops, where protein ...
Olga Bazalova (14256296), Jan Martinek (8519184), Ralf Stanewsky (264551), Vlastimil Smykal (193852), Astrid Giesecke (8069885), David Dolezel (6953867), Nirav Thakkar (14256293)   +6 more
core   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction [PDF]

Oncogene, 2010
The Cdc25A protein phosphatase drives cell-cycle transitions by activating cyclin-dependent protein kinases. Failure to regulate Cdc25A leads to deregulated cell-cycle progression, bypass of cell-cycle checkpoints and genome instability. Ubiquitin-mediated proteolysis has an important role in balancing Cdc25A levels.
Honaker, Yuchi, Piwnica-Worms, Helen
openaire   +2 more sources

Structural Basis for the Potent and Selective Inhibition of Casein Kinase 1 Epsilon

, 2016
Casein kinase 1 epsilon (CK1ε) and its closest homologue CK1δ are key regulators of diverse cellular processes. We report two crystal structures of PF4800567, a potent and selective inhibitor of CK1ε, bound to the kinase domains of human CK1ε and CK1δ as
Xin Huang (11077), Huilin Zhao (2013511), Alexander M. Long (1656211)   +2 more
core   +1 more source