Results 91 to 100 of about 43,522 (228)

Regulation of Casein Kinase-2 (CK2) Activity by Inositol Phosphates [PDF]

Journal of Biological Chemistry, 2004
Casein kinase 2 (CK2) was one of the first protein kinases to be discovered and has been suggested to be responsible for as much as one-fifth of the eukaryotic phosphoproteome. Despite being responsible for the phosphorylation of a vast array of proteins central to numerous dynamic cellular processes, the activity of CK2 appears to be unregulated.
Solyakov, L., Cain, K., Tracey, B.M., Jukes, R., Riley, A.M., Potter, B.V.L., Tobin, Andrew B.   +6 more
openaire   +3 more sources

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source

Supplementary Figure Legends from Cortactin Phosphorylation by Casein Kinase 2 Regulates Actin-Related Protein 2/3 Complex Activity, Invadopodia Function, and Tumor Cell Invasion

, 2019
Supplementary Figure Legends from Cortactin Phosphorylation by Casein Kinase 2 Regulates Actin-Related Protein 2/3 Complex Activity, Invadopodia Function, and Tumor Cell ...
Johnathan E. Castaño (15079128), Amanda G. Ammer (15079116), Erik T. Interval (15079119), Jessica L. Allen (7446593), Steven M. Markwell (14925990), Scott A. Weed (15076041), Brenen W. Papenberg (15079122), River A. Hames (15079125), Dorothy A. Schafer (15079131)   +8 more
core   +1 more source

N-Substituted Indole-2 and 3-Carboxamide Derivatives as Inhibitors of Human Protein Kinase CK2: In Vitro Assay and Molecular Modelling Study

Acta Chimica Slovenica, 2013
Protein kinase CK2 (Casein Kinase 2) is involved in cell growth; proliferation and suppression of apoptosis. Hence, it strongly promotes cell survival and can be considered an important target for human cancers.
Süreyya Ölgen, Andreas Gratz, Zühal Kılıç, Joachim Jose   +3 more
doaj  

Long noncoding RNA HIKER regulates erythropoiesis in Monge’s disease via CSNK2B

The Journal of Clinical Investigation, 2023
Excessive erythrocytosis (EE) is a major hallmark of patients suffering from chronic mountain sickness (CMS, also known as Monge’s disease) and is responsible for major morbidity and even mortality in early adulthood.
Priti Azad, Dan Zhou, Hung-Chi Tu, Francisco C. Villafuerte, David Traver, Tariq M. Rana, Gabriel G. Haddad   +6 more
doaj   +1 more source

A Nutrient‐Responsive LuxR Regulator Orchestrates Effector Gene Expression Across the Legionella Genus

Molecular Microbiology, EarlyView.
LexR1 is a LuxR‐type regulator that links nutrient sensing to effector gene expression in Legionella. Activated by a casamino acid‐derived ligand, LexR1 directly controls multiple effector genes using a conserved regulatory element present in numerous putative effectors across different Legionella species.
Chen Adler, Gil Segal
wiley   +1 more source

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source

Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade

Frontiers in Molecular Neuroscience, 2018
Oligodendrocytes are highly vulnerable to glutamate excitotoxicity, a central mechanism involved in tissue damage in Multiple Sclerosis (MS). Sustained activation of AMPA receptors in rat oligodendrocytes induces cytosolic calcium overload, mitochondrial
Manuel Canedo-Antelo, Manuel Canedo-Antelo, Manuel Canedo-Antelo, Mari Paz Serrano, Mari Paz Serrano, Mari Paz Serrano, Andrea Manterola, Andrea Manterola, Andrea Manterola, Asier Ruiz, Asier Ruiz, Asier Ruiz, Francisco Llavero, Francisco Llavero, Susana Mato, Susana Mato, Susana Mato, José Luis Zugaza, José Luis Zugaza, José Luis Zugaza, Fernando Pérez-Cerdá, Fernando Pérez-Cerdá, Fernando Pérez-Cerdá, Carlos Matute, Carlos Matute, Carlos Matute, María Victoria Sánchez-Gómez, María Victoria Sánchez-Gómez, María Victoria Sánchez-Gómez   +28 more
doaj   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source