Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia [PDF]
BMC Cancer, 2019 Background The tumor suppressor protein phosphatase and tensin homolog (PTEN) is a key regulator of the PI3K/AKT pathway which is frequently altered in a variety of tumors including a subset of acute B-lymphoblastic leukemias (B-ALL).
Anna Richter +11 more
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Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction [PDF]
Cell Reports, 2018 Summary: Spt6 is a histone chaperone that associates with RNA polymerase II and deposits nucleosomes in the wake of transcription. Although Spt6 has an essential function in nucleosome deposition, it is not known whether this function is influenced by ...
Raghuvar Dronamraju +10 more
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Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na+ channel [PDF]
Scientific Reports, 2021 Activity of the Epithelial Na+ Channel (ENaC) in the distal nephron fine-tunes renal sodium excretion. Appropriate sodium excretion is a key factor in the regulation of blood pressure.
Tarek Mohamed Abd El-Aziz +7 more
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Casein kinase II promotes piRNA production through direct phosphorylation of USTC component TOFU-4 [PDF]
Nature CommunicationsPiwi-interacting RNAs (piRNAs) are genomically encoded small RNAs that engage Piwi Argonaute proteins to direct mRNA surveillance and transposon silencing.
Gangming Zhang +3 more
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Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis. [PDF]
PLoS ONE, 2016 Although alpha (α)B-crystallin is expressed in articular chondrocytes, little is known about its role in these cells. Protein kinase casein kinase 2 (CK2) inhibition induces articular chondrocyte death.
Sung Won Lee +6 more
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The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase. [PDF]
PLoS ONE, 2013 Alternative splicing of pre-mRNA is a highly regulated process that allows cells to change their genetic informational output. These changes are mediated by protein factors that directly bind specific pre-mRNA sequences.
J Matthew Taliaferro +6 more
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Rotavirus NSP1 Requires Casein Kinase II-Mediated Phosphorylation for Hijacking of Cullin-RING Ligases [PDF]
mBio, 2017 The rotavirus nonstructural protein NSP1 repurposes cullin-RING E3 ubiquitin ligases (CRLs) to antagonize innate immune responses. By functioning as substrate adaptors of hijacked CRLs, NSP1 causes ubiquitination and proteasomal degradation of host ...
Kaitlin A. Davis +2 more
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Casein kinase II inhibitor enhances production of infectious genotype 1a hepatitis C virus (H77S). [PDF]
PLoS ONE, 2014 Genotype 2a JFH1 virus has substantially contributed to the progress of HCV biology by allowing entire viral life cycle of HCV in cell culture. Using this genotype 2a virus, casein kinase II (CKII) was previously identified as a crucial host factor in ...
Seungtaek Kim +4 more
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Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos [PDF]
Biology Open, 2017 Centrosomes are the primary microtubule-organizing centers that orchestrate microtubule dynamics during the cell cycle. The correct number of centrosomes is pivotal for establishing bipolar mitotic spindles that ensure accurate segregation of chromosomes.
Jeffrey C. Medley +4 more
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β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression
Cell Reports, 2018 Summary: Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell-cycle phase.
Ioanna Mavrommati +10 more
doaj +2 more sources