Synthetic phosphopeptides are substrates for casein kinase II
FEBS Letters, 1990 Casein kinase II is a protein serine/threonine kinase that exhibits a preference for acidic substrates. Previous studies have demonstrated that a glutamic acid 3 amino acids C‐terminal (+3) to a serine or threonine is required for phosphorylation. To examine the ability of phosphoserine and phosphothreonine residues to serve as specificity determinants
W. Litchfield, David +5 more
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Activation of Casein Kinase II by Gallic Acid Induces BIK–BAX/BAK-Mediated ER Ca++-ROS-Dependent Apoptosis of Human Oral Cancer Cells [PDF]
Frontiers in Physiology, 2017 Induction of the generation of endoplasmic reticulum (ER) calcium (Ca++)-mediated reactive oxygen species (ROS) by gallic acid (GA) has been implicated in the mitochondrial apoptotic death of human oral cancer (OC) cells, but the molecular mechanism by ...
Meng-Liang Lin, Shih-Shun Chen
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Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins. [PDF]
PLoS ONE, 2014 BackgroundTrans-activation Response DNA-binding Protein-43 (TDP-43) lesions are observed in Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration with ubiquitin inclusions (FTLD-TDP) and 25-50% of Alzheimer's Disease (AD) cases.
Yari Carlomagno +10 more
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The peptide microarray "ChloroPhos1.0" identifies new phosphorylation targets of plastid casein kinase II (pCKII) in Arabidopsis thaliana. [PDF]
PLoS ONE, 2014 We report the development of a peptide microarray based on previously determined phosphorylation sites in chloroplast proteins. Altogether, 905 peptides were spotted as 15mers in nine replicates onto glass slides.
Anna Schönberg +7 more
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Assembly and disassembly dynamics of nonmuscle myosin II control endosomal fission
Cell Reports, 2023 Summary: Endocytic vesicular trafficking requires merging of two lipid bilayers, but how the two lipid bilayers can come close together during fusion and fission in endocytic trafficking is not well explored.
Joy Kar +3 more
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Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. [PDF]
PLoS Pathogens, 2008 Hepatitis C virus (HCV) is a significant pathogen, infecting some 170 million people worldwide. Persistent virus infection often leads to cirrhosis and liver cancer.
Timothy L Tellinghuisen +2 more
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Using bacteria to determine protein kinase specificity and predict target substrates. [PDF]
PLoS ONE, 2012 The identification of protein kinase targets remains a significant bottleneck for our understanding of signal transduction in normal and diseased cellular states.
Michael F Chou +5 more
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The Role of Protein Kinase CK2 in Development and Disease Progression: A Critical Review
Journal of Developmental Biology, 2022 Protein kinase CK2 (CK2) is a ubiquitous holoenzyme involved in a wide array of developmental processes. The involvement of CK2 in events such as neurogenesis, cardiogenesis, skeletogenesis, and spermatogenesis is essential for the viability of almost ...
Daniel Halloran, Venu Pandit, Anja Nohe
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HGG Advances, 2022 Summary: CSNK2B encodes for casein kinase II subunit beta (CK2β), the regulatory subunit of casein kinase II (CK2), which is known to mediate diverse cellular pathways.
Maria Asif +32 more
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CK2 Regulation: Perspectives in 2021
Biomedicines, 2021 The protein kinase CK2 (CK2) family encompasses a small number of acidophilic serine/threonine kinases that phosphorylate substrates involved in numerous biological processes including apoptosis, cell proliferation, and the DNA damage response.
Scott E. Roffey, David W. Litchfield
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