Results 31 to 40 of about 30,523 (236)

Casein Kinase II in Theileriosis

Science, 1995
East Coast fever is an acute, leukemia-like disease of cattle and Cape buffalo that is endemic in eastern, central, and southern Africa, where the disease causes high mortality and losses in livestock production. It is caused by the parasite Theileria parva, which infects bovine lymphocytolysis.
openaire   +3 more sources

Biochemical purification of Drosophila casein kinase II.

, 2013
A) Purification strategy for endogenous casein kinase II. B) Protein composition of peak fraction of activity from the final heparin column visualized by SDS-PAGE and silver-staining.
Lori A. Kohlstaedt (379821), Donald C. Rio (25376), J. Matthew Taliaferro (379816), Nathalie E. Cheng (379820), Julie L. Aspden (379818), Dhruv Marwha (379817), Daniela Mavrici (379819)   +6 more
core   +1 more source

Casein kinase 2 controls synapse organization and stability [PDF]

, 2013
Synapse remodeling is a local and dynamic process, requiring constant modifications of the neuronal network. Post-translational modifications, such as reversible phosphorylation by kinases and phosphatases, play a crucial role in synapse development and ...
Bulat, Victoria
core   +1 more source

Mechanisms regulating resistance to inhibitors of topoisomerase II

Frontiers in Pharmacology, 2013
Inhibitors of topoisomerase II (topo II) are clinically effective in the management of hematological malignancies and solid tumors. The efficacy of anti-tumor drugs targeting topo II is often limited by resistance and studies with in vitro cell culture ...
Ram N. Ganapathi, Mahrukh K. Ganapathi
doaj   +1 more source

Protein kinase 2 (CK2): a potential regulator of immune cell development and function in cancer

Immunological Medicine, 2021
Protein kinase CK2, formally known as casein kinase II, is ubiquitously expressed and highly conserved serine/threonine or tyrosine kinase enzyme that regulates diverse signaling pathways responsible for cellular processes (i.e., cell proliferation and ...
Kazim Husain, Tanika T. Williamson, Nadine Nelson, Tomar Ghansah   +3 more
doaj   +1 more source

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

Molecular Cancer, 2010
Background Myxoid liposarcoma is a relatively common malignant soft tissue tumor, characterized by a (12;16) translocation resulting in a FUS-DDIT3 fusion gene playing a pivotal role in its tumorigenesis.
Szuhai Karoly, Bruijn Inge, Schrage Yvonne M, Willems Stefan M, Hogendoorn Pancras CW, Bovée Judith VMG   +5 more
doaj   +1 more source

Casein kinase II accumulation in the nucleolus and its role in nucleolar phosphorylation

, 1988
A rabbit antiserum against highly purified casein kinase II from mouse tumor cells was used for immunolocalization of the enzyme in fixed, permeabilized mouse cells.
Anderer, F., Pfaff, M.
core   +1 more source

CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions

Cell Death and Disease
The aberrant upregulation of Yes-associated protein 1 (YAP1) in a variety of solid cancers contributes to tumor progression and poor clinical outcomes, rendering it an appealing therapeutic target.
Lei Huang, Yalei Wen, Qin Guo, Caishi Zhang, Xiao Yang, Mei Li, YiXia Liu, Xinying Li, Jiaxin Tang, Xiaofeng Zhou, Qi Qi, Haoxing Zhang, Tongzheng Liu   +12 more
doaj   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Identification of casein kinase II as a major endogeneous caldesmon kinase in sheep aorta smooth muscle

, 1993
A caldesmon kinase activity was detected in an ATP extract of the myofibril-like pellet from sheep aorta. The enzyme was purified 745-fold and was identified as casein kinase II on the basis of molecular size, substrate specificity, and high sensitivity ...
Gusev, Nikolai B., Collins, John H., Charles S. Redwood, Vorotniko, Alexander V., Steven B. Marston, Redwood, Charles S., John H. Collins, Hua, Suming, Nikolai B. Gusev, Alexander V. Vorotniko, Suming Hua, Marston, Steven B.   +11 more
core   +1 more source