Results 41 to 50 of about 30,523 (236)
Journal of Lipid Research, 2012 Phosphatidate (PA) phosphatase, the enzyme that catalyzes the penultimate step in triacylglycerol synthesis, is a cytosolic enzyme that must associate with the membrane where its substrate PA resides.
Zhi Xu, Wen-Min Su, George M. Carman
doaj +1 more source
CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
M‐phase‐specific cdc2 protein kinase phosphorylates the β subunit of casein kinase II and increases casein kinase II activity [PDF]
European Journal of Biochemistry, 1990 The M‐phase‐specific cdc2 (cell division control) protein kinase (a component of the M‐phase‐promoting factor) was found to activate casein kinase II in vitro. The increase in casein kinase II activity ranged over 1.5–5‐fold. Increase in activity was prevented if ATP was replaced during the activation reaction by a non‐hydrolysable analogue.
O, Mulner-Lorillon +6 more
openaire +2 more sources
Dynamic Single‐Binding Event Profiling With on‐Chip Microlenses for Wash‐Free Digital Biosensing
Advanced Science, EarlyView.A microlens‐enhanced platform enables real‐time tracking and digital counting of single‐binding events using conventional bright‐field microscopy. Amplified scattering signals from gold nanoparticle labels and kinetic signature analysis allow wash‐free discrimination between specific and nonspecific interactions, while providing kinetic and mechanistic
Tingting Zhan +12 more
wiley +1 more source
Casein kinase II phosphorylates the synaptic vesicle protein p65
, 1993 p65 (synaptotagmin), an abundant synaptic vesicle protein, has been implicated in the processes of vesicle docking and fusion. To characterize further the properties of this important neuronal protein, we have investigated its phosphorylation in vitro ...
KG Miller, MK Bennett, RH Scheller
core +1 more source
Stem Cell Research & Therapy, 2017 Background Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage.
Hemanth Akkiraju +5 more
doaj +1 more source
FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression
Cell Reports, 2020 Summary: N6-Methyladenosine (m6A) modification is the major chemical modification in mRNA that controls fundamental biological processes, including cell proliferation.
Mayumi Hirayama +10 more
doaj +1 more source
Advanced Science, EarlyView.In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang +6 more
wiley +1 more source
The cDNAs coding for the α- and β-subunits of Xenopus laevis casein kinase II [PDF]
, 1992 Using a λgt10 cDNA library obtained from Xenopus laevis oocytes and probes derived from the known sequences of the human and Drosophila genes, a cDNA coding for the α-subunit of the X. laevis casein kinase II was isolated.
Catherine C. Allende +7 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan +6 more
wiley +1 more source