Results 111 to 120 of about 34,988 (231)
Role of acidic residues as substrate determinants for casein kinase I
Journal of Biological Chemistry, 1991 Sites phosphorylated by casein kinase I have been characterized by the presence of acidic amino acids NH2-terminal to the modified residue. Recently, phosphoserine was shown to be a particularly effective determinant for casein kinase I action when present in the motif -S(P)-X-X-S- (Flotow, H., Graves, P. R., Wang, A., Fiol, C. J., Roeske, R.
H, Flotow, P J, Roach
openaire +2 more sources
Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.ERO1A exhibits oncogenic functions, including promoting tumour progression, metastasis, epithelial‒mesenchymal transition, angiogenesis, immune evasion and metabolic reprogramming. ERO1A is also identified as a diagnostic biomarker and a factor contributing to therapy resistance (chemotherapy and immunotherapy).
Jing Mao, Kai Wang
wiley +1 more source
MedComm, Volume 7, Issue 7, July 2026.This review illustrates the key mechanisms of osimertinib resistance in EGFR‑mutant NSCLC, including EGFR‑dependent mutations, bypass pathway activation, and SMARCA4‑mediated epigenetic regulation. We also summarize emerging targeted therapies and future perspectives to overcome EGFR‑TKI resistance.
Junfeng Guo, Qiuyuan Wen, Songqing Fan
wiley +1 more source
Analysis of structure, function and epitopes of spirometra erinaceieuropaei casein kinase I
, 2015 Spirometra erinaceieuropaei casein kinase I (SeCKI) was analyzed using bioinformatical methods to predict its structure and function based on the deduced amino acid sequence from full length cDNA sequence of SeCKI gene with online sites and software ...
Yashotha A/P Nardarajan
core
, 2007 dissertationCasein kinase I epsilon (CKI?) and casein kinase I delta (CKI?) are members of the CKI serine/threonine protein kinase family. These two highly-related kinases are ubiquitously expressed in mammalian tissues and are implicated in multiple ...
Tsai, I-Chun
core +1 more source
Chemical and Technological Aspects of Magnetic Particles for Cancer Liquid Biopsy Applications
ChemistryOpen, Volume 15, Issue 7, July 2026.Magnetic bead engineering for liquid biopsy diagnostics reviews advances in magnetic bead design for the selective enrichment of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and extracellular vesicles (EVs) from complex biofluids.
Beatriz Naranjo‐Martínez +9 more
wiley +1 more source
MoleculesThe host kinase casein kinase 2 (CSNK2) has been proposed to be an antiviral target against β-coronaviral infection. To pharmacologically validate CSNK2 as a drug target in vivo, potent and selective CSNK2 inhibitors with good pharmacokinetic properties ...
Han Wee Ong +16 more
doaj +1 more source
Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.Betaine alleviated NEFA‐induced oxidative stress, which served as a central mechanistic link between fatty liver and mammary dysfunction, and concurrently improved milk protein synthesis via regulation of the Nrf2‐JAK2/STAT5/mTOR axis. ABSTRACT Background Fatty liver is highly prevalent in dairy cows and poses a significant challenge to the dairy ...
Wenyan Yan +6 more
wiley +1 more source
Casein Kinase I Transduces WNT Signals
, 2005 Wnt signaling controls a diverse array of processes including cell growth, oncogenesis, and development. Components of the Wnt cascade are altered in several human cancers including colon cancers and melanomas.
Peters, John Michael
core