Results 111 to 120 of about 30,523 (236)
Zaporožskij Medicinskij Žurnal, 2015 Aimed to elaborate new group of protein kinase inhibitors we conducted receptor-based screening (docking, QSAR modeling) and biochemical testing for derivatives of (2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thiones. Methods and results.
I. S. Nosulenko +4 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3866-3884, July 2026.Abstract Background and Purpose The absence of the protein dystrophin in Duchenne muscular dystrophy (DMD) leads to progressive muscle weakness, failing regeneration and deregulation of nitric oxide (NO) signalling. We focused on L‐citrulline, a precursor of L‐arginine, required for NO production in muscle, which is reduced in dystrophic mdx muscle ...
Lisamaura Tulimiero +14 more
wiley +1 more source
, 2008 Casein kinase II consists of catalytic (alpha) and regulatory (beta) subunits complexed into a heterotetrameric alpha 2 beta 2 structure. Full-length cDNAs encoding the alpha and beta subunits of human casein kinase II were subcloned into an expression ...
Heller-Harrison, Robin A. +1 more
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RNA-binding protein kinase from amphibian oocytes is a casein kinase II
, 1984 RNA-binding protein kinase from amphibian oocytes modifies serine and threonine residues in the molecules of substrates and utilizes both ATP and GTP. Low concentrations of heparin inhibit protein kinase. The foregoing suggests that this enzyme is casein
Stepanov, A.S. +3 more
core +1 more source
The impact of the human DNA topoisomerase II C-terminal domain on activity [PDF]
, 2008 Background Type II DNA topoisomerases (topos) are essential enzymes needed for the resolution of topological problems that occur during DNA metabolic processes.
West, K.L. +11 more
core +1 more source
Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation.
PLoS ONE, 2008 The production of a functional mRNA is regulated at every step of transcription. An area not well-understood is the transition of RNA polymerase II from elongation to termination. The S.
Jessica L Dermody +9 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren +8 more
wiley +1 more source
Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis.
, 1992 In human epidermal carcinoma A431 cells, the beta subunit of casein kinase II is phosphorylated at an autophosphorylation site and at serine 209 which can be phosphorylated in vitro by p34cdc2 (Litchfield, D. W., Lozeman, F. J., Cicirelli, M.
Eisenman, R N +4 more
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A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Characterization of casein kinase II of Trypanosoma (nannomonas) congolense.
, 2017 Casein kinase II from Trypanosoma congolense has been partially purified by chromatography on DEAE-cellulose and heparin-agarose and this subunit exhibits protein kinase activity with casein as the substrate. The enzyme adhered to both the DEAE-cellulose
Janoo, R.T.K.
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