Results 71 to 80 of about 30,523 (236)

Identification of the site phosphorylated by casein kinase II in smooth muscle caldesmon

, 1991
Phosphorylation of avian gizzard caldesmon by casein kinase II was investigated. The enzyme incorporates about 1 mol of phosphate per mol of caldesmon. All sites of phosphorylation are located in short chymotryptic peptides with Mr, 25–27 kDa or in the ...
Gusev, Nikolai B., Alexander V. Vorotnikov, Natalia V. Bogatcheva, Collins, John H., Vorotnikov, Alexander V., John H. Collins, Wawrzynow, Alicja, Alicja Wawrzynow, Nikolai B. Gusev, Bogatcheva, Natalia V.   +9 more
core   +1 more source

Regulation of Arrestin-3 Phosphorylation by Casein Kinase II [PDF]

Journal of Biological Chemistry, 2002
Arrestins play an important role in regulating the function of G protein-coupled receptors including receptor desensitization, internalization, down-regulation, and signaling via nonreceptor tyrosine kinases and mitogen-activated protein kinases. Previous studies have revealed that arrestins themselves are also subject to regulation.
You-Me, Kim, Larry S, Barak, Marc G, Caron, Jeffrey L, Benovic   +3 more
openaire   +2 more sources

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, EarlyView.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

Convergent digestive adaptation to resource limitation in an insular lizard across a microgeographic archipelago

Journal of Animal Ecology, EarlyView.
Replicated mainland–islet populations of the Skyros wall lizard reveal consistent divergence in digestive physiology, including gut morphology, passage time, digestive efficiency and enzyme activity. These results show how ecological variation in resource availability can shape digestive performance across populations in insular environments.
Aikaterini Reppa, Foteini Paraskevopoulou, Kyriaki Papageorgiou, Giannis Tounias, Panayiota Santikou, Aristeidis Parmakelis, Efstratios D. Valakos, Panayiotis Pafilis, Kostas Sagonas   +8 more
wiley   +1 more source

Phosphorylation of lipin 1 beta phosphatidate phosphatase by casein kinase II

, 2018
Lipin is a phosphatidate phosphatase enzyme that catalyzes the penultimate step in triacylglycerol synthesis, the conversion of phosphatidic acid to diacylglycerol. By controlling this step, lipin regulates both triacylglycerol and phospholipid synthesis,

core   +1 more source

Identifying and characterizing casein kinase II in human platelets [PDF]

Blood, 1994
Abstract We have recently shown that inhibition of protein phosphatases in platelets causes increases in protein phosphorylations with a concomitant inhibition of platelet responses. The burst in protein phosphorylation appears to be catalyzed by messenger-independent protein kinases.
C H, Hoyt, C J, Oh, J B, Beekman, D W, Litchfield, K M, Lerea   +4 more
openaire   +3 more sources

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

Increase in cytoplasmic casein kinase II-type activity accompanies neurite outgrowth after DNA synthesis inhibition in NIA-103 neuroblastoma cells

, 1992
Whereas cells from most clonal lines derived from the murine neuroblastoma C1300 tumor can be induced to differentiate by serum withdrawal from culture medium, the NIA-103 clonal cell line has been considered unable to extend axon-like processes ...
Armas Portela, Rosario, Díaz-Nido, Javier, Ávila, Jesús   +2 more
core   +1 more source

Inhibition of casein kinase II by heparin.

Journal of Biological Chemistry, 1980
Casein kinase II, a cyclic nucleotide-independent protein kinase from rabbit reticulocytes, was shown to be inhibited by heparin. Heparin specifically inhibited the enzyme and had no effect on other protein kinases, including casein kinase I, the type I and II cAMP-dependent protein kinases, protease-activated kinase I, and the hemin-controlled ...
G M, Hathaway, T H, Lubben, J A, Traugh
openaire   +2 more sources

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source