Results 21 to 30 of about 4,588 (199)

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria [PDF]

mLife
The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substantiated in ...
Genhui Xiao, Yumeng Cui, Liangliang Zhou, Chuya Niu, Bing Wang, Jinglan Wang, Shaoyang Zhou, Miaomiao Pan, Chi Kin Chan, Yan Xia, Lan Xu, Yu Lu, Shawn Chen   +12 more
doaj   +2 more sources

Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria [PDF]

mBio, 2015
A novel type of antibacterial screening method, a target mechanism-based whole-cell screening method, was developed to combine the advantages of target mechanism- and whole-cell-based approaches. A mycobacterial reporter strain with a synthetic phenotype
Wilfried Moreira, Grace J. Y. Ngan, Jian Liang Low, Anders Poulsen, Brian C. S. Chia, Melgious J. Y. Ang, Amelia Yap, Justina Fulwood, Umayal Lakshmanan, Jolander Lim, Audrey Y. T. Khoo, Horst Flotow, Jeffrey Hill, Ravikiran M. Raju, Eric J. Rubin, Thomas Dick   +15 more
doaj   +2 more sources

Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis [PDF]

Nature Communications
The caseinolytic protease (Clp) system has recently emerged as a promising anti-tuberculosis target. The anti-cancer drug bortezomib exhibits potent anti-mycobacterial activity and binds to Mycobacterium tuberculosis (Mtb) Clp protease complexes.
Biao Zhou, Yamin Gao, Heyu Zhao, Banghui Liu, Han Zhang, Cuiting Fang, Hang Yuan, Jingjing Wang, Zimu Li, Yi Zhao, Xiaodong Huang, Xiyue Wang, A. Sofia. F. Oliveira, James Spencer, Adrian J. Mulholland, Steven G. Burston, Jinxing Hu, Ning Su, Xinwen Chen, Jun He, Tianyu Zhang, Xiaoli Xiong   +21 more
doaj   +3 more sources

Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P. [PDF]

Am J Obstet Gynecol, 2010
The objective of the study was to assess antibodies against Chlamydia trachomatis heat shock proteins (HSP) in patients with tubal factor infertility (TFI), infertility controls (IFC), and fertile controls (FC). HSPs assist organisms in surviving caustic environments such as heat.Twenty-one TFI, 15 IFC, and 29 FC patients were enrolled after ...
Rodgers AK, Wang J, Zhang Y, Holden A, Berryhill B, Budrys NM, Schenken RS, Zhong G.   +7 more
europepmc   +4 more sources

Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum. [PDF]

J Biol Chem, 2013
The ATP-dependent caseinolytic protease, ClpP, is highly conserved in bacteria and in the organelles of different organisms. In cyanobacteria, plant plastids, and the apicoplast of the genus Plasmodium, a noncatalytic paralog of ClpP, termed ClpR, has been identified. ClpRs are found to form heterocomplexes with ClpP resulting in a ClpRP tetradecameric
El Bakkouri M, Rathore S, Calmettes C, Wernimont AK, Liu K, Sinha D, Asad M, Jung P, Hui R, Mohmmed A, Houry WA.   +10 more
europepmc   +4 more sources

Targeted proteomics reveal α-MSH-like Enterobacterial ClpB protein in gut microbiota of patients with anorexia nervosa [PDF]

npj Biofilms and Microbiomes
α-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide. In this exploratory study, a targeted proteomic approach was used to detect α-MSH-like bacterial proteins in the gut microbiota of patients with anorexia nervosa (AN) and healthy ...
Lisa Bremard, Lisa Wallart, Emilie Lahaye, Mohamed Amine Ben Mlouka, Jochen Seitz, Beate Herpertz-Dahlmann, Sergueï O. Fetissov   +6 more
doaj   +2 more sources

Antibodies directed against bacterial antigens in sera of Polish patients with primary biliary cholangitis [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundPrimary biliary cholangitis (PBC) is a cholestatic, autoimmune liver disease with the presence of characteristic autoantibodies. The aim of the work was to determine the level of antibodies directed against bacterial antigens: Chlamydia ...
Alicja Bauer, Andrzej Habior
doaj   +2 more sources

Targeting human caseinolytic protease P (ClpP) as a novel therapeutic strategy in ovarian cancer

MedComm – Oncology, 2022
Ovarian cancer (OC) is currently one of the most life‐threatening types of gynecological malignancy with limited treatment options and poor clinical outcomes.
Baozhu Luo, Jiangnan Zhang, Wenliang Qiao, Yuanzhen Zhou, Jiasheng Huang, Tao Yang, Youfu Luo   +6 more
doaj   +2 more sources

From Beer to Cheese: Characterization of Caseinolytic and Milk-Clotting Activities of Proteases Derived from Brewer’s Spent Grain (BSG) [PDF]

Foods
This study explores the extraction and characterization of proteolytic enzymes from brewer’s spent grain (BSG) and their potential as sustainable coagulants in the dairy industry.
Maximiliano M. Villegas, Johana N. Silva, Florencia R. Tito, Claudia V. Tonón, Fernando F. Muñoz, Alfonso Pepe, María G. Guevara   +6 more
doaj   +2 more sources

Production of mycelial biomass, proteases and protease inhibitors by Ganoderma lucidum under different submerged fermentation conditions [PDF]

Brazilian Journal of Biology, 2023
Ganoderma lucidum is a medicinal mushroom widely recognized as a source of biomolecules with pharmacological properties, however, little is known about the factors that influence the synthesis of bioactive proteins by this fungus when cultivated under ...
V. A. Pessoa, L. B. N. Soares, G. L. Silva, A. S. Vasconcelos, J. F. Silva, J. I. Fariña, S. D. Oliveira-Junior, C. Sales-Campos, L. R. Chevreuil   +8 more
doaj   +1 more source