Results 31 to 40 of about 4,588 (199)

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +4 more sources

Separation, purification, and phylogenetic characterization of detergent-compatible protease produced by Penicillium species

Medical Journal of Babylon, 2022
Background: Filamentous fungal forms are said to secrete multiple peptidases with portent detergent capabilities in addition to their usage in food, beverages, and pharmaceutical industries.
Omar Sadik Shalal
doaj   +1 more source

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis

Communications Biology, 2023
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria.
Chenxi Guo, Yuan Xiao, Jingkai Gu, Peikun Zhao, Zhe Hu, Jiahuan Zheng, Renwu Hua, Zhuo Hai, Jiaping Su, Jian V. Zhang, William S. B. Yeung, Tianren Wang   +11 more
doaj   +1 more source

PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum

Cell Reports, 2017
Summary: The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective.
Anat Florentin, David W. Cobb, Jillian D. Fishburn, Michael J. Cipriano, Paul S. Kim, Manuel A. Fierro, Boris Striepen, Vasant Muralidharan   +7 more
doaj   +1 more source

Pyrazinamide triggers degradation of its target aspartate decarboxylase

Nature Communications, 2020
It has been shown that the bioactive component of pyrazinamide, pyrazinoic acid (POA), blocks coenzyme A biosynthesis in M. tuberculosis by binding to the aspartate decarboxylase PanD.
Pooja Gopal, Jickky Palmae Sarathy, Michelle Yee, Priya Ragunathan, Joon Shin, Shashi Bhushan, Junhao Zhu, Tatos Akopian, Olga Kandror, Teck Kwang Lim, Martin Gengenbacher, Qingsong Lin, Eric J. Rubin, Gerhard Grüber, Thomas Dick   +14 more
doaj   +1 more source

Vibrio proteases for biomedical applications: Modulating the proteolytic secretome of v. alginolyticus and v. parahaemolyticus for improved enzymes production [PDF]

, 2019
Proteolytic enzymes are of great interest for biotechnological purposes, and their large-scale production, as well as the discovery of strains producing new molecules, is a relevant issue.
Ghersi G., Nicosia A., Salamone M., Tagliavia M.   +3 more
core   +1 more source

Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing [PDF]

, 2017
Background Six Plasmodium species are known to naturally infect humans. Mixed species infections occur regularly but morphological discrimination by microscopy is difficult and multiplicity of infection (MOI) can only be evaluated by molecular methods ...
Lalremruata, Albert, Jeyaraj, Sankarganesh, Engleitner, Thomas, Joanny, Fanny, Lang, Annika, Belard, Sabine, Mombo-Ngoma, Ghyslain, Ramharter, Michael, Kremsner, Peter G., Mordmueller, Benjamin, Held, Jana   +10 more
core   +1 more source

Human μ-calpain: Simple isolation from erythrocytes and characterization of autolysis fragments [PDF]

, 2001
Heterodimeric μ-calpain, consisting of the large (80 kDa) and the small (30 kDa) subunit, was isolated and purified from human erythrocytes by a highly reproducible four-step purification procedure.
Crawford C., Croall D. E., Graham-Siegenthaler K., Guroff G., Kitahara A., McClelland P., Nishimura T., Sasaki T., Sorimachi H., Sorimachi H., Sorimachi H., Thompson V.F., Yoshimura N., Zimmermann U.J.P.   +13 more
core   +1 more source

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection [PDF]

, 2017
Urinary tract infections: targeting enzymes might help Identifying bacterial and host enzymes that support biofilm formation may help prevent urinary tract infections caused by catheters.
Caparon, Michael G, Cusumano, Zachary T, Flores-Mireles, Ana L, Hultgren, Scott J, Takagi, Enzo, Xu, Wei   +5 more
core   +3 more sources

Open and compressed conformations of Francisella tularensis ClpP [PDF]

, 2017
Caseinolytic proteases are large oligomeric assemblies responsible for maintaining protein homeostasis in bacteria and in so doing influence a wide range of biological processes.
Alexopoulos, Battye, Bond, Brötz-Oesterhelt, Böttcher, Böttcher, Chen, Cruickshank, Emsley, Evans, Frees, Gasteiger, Geiger, Gersch, Holm, Hunter, Ingvarsson, Kabsch, Krissinel, Lee, McCoy, Moynie, Murshudov, Sievers, Sowole, Touw, Winn, Yu, Zhang   +28 more
core   +2 more sources