Results 41 to 50 of about 4,588 (199)

ClpB is an essential stress regulator of Mycobacterium tuberculosis and endows survival advantage to dormant bacilli

International Journal of Medical Microbiology, 2020
The ability to tolerate multiple host derived stresses, resist eradication and persist within the infected individuals is central to the pathogenicity of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB).
Prajna Tripathi, Lalit K. Singh, Sujata Kumari, Owais R. Hakiem, Janendra K. Batra   +4 more
doaj   +1 more source

Bacterial caseinolytic proteases as novel targets for antibacterial treatment

International Journal of Medical Microbiology, 2014
Bacterial Clp proteases are important for protein turnover and homeostasis in order to maintain vital cellular functions particularly under stress conditions. Apart from their crucial role in general protein quality control by degrading abnormally folded or otherwise aberrant or malfunctioning proteins, their temporally and spatially precise ...
Heike, Brötz-Oesterhelt, Peter, Sass
openaire   +2 more sources

Crystal Structure of the Caseinolytic Protease Gene Regulator, a Transcriptional Activator in Actinomycetes [PDF]

Journal of Biological Chemistry, 2009
Human pathogens of the genera Corynebacterium and Mycobacterium possess the transcriptional activator ClgR (clp gene regulator) which in Corynebacterium glutamicum has been shown to regulate the expression of the ClpCP protease genes. ClgR specifically binds to pseudo-palindromic operator regions upstream of clpC and clpP1P2. Here, we present the first
Santina, Russo, Jens-Eric, Schweitzer, Tino, Polen, Michael, Bott, Ehmke, Pohl   +4 more
openaire   +2 more sources

Purification and proteolytic activity of Caseinolytic protease (Clp) from Lactobacillus plantarum IIA-1AS [PDF]

AIP Conference Proceedings, 2020
A gene encoding caseinolytic protease (Clp) was isolated from Lactobacillus plantarum IIA-1A5 and overexpressed in Escherichia coli. This enzyme belongs to the serine protease and plays essential role in cellular protein homeostasis. This study investigated the purification and proteolytic activity of the protease produced by Lactobacillus plantarum ...
Olfa Mega, Cece Sumantri, Irma Isnafia Arief, Cahyo Budiman   +3 more
openaire   +1 more source

Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury. [PDF]

, 2013
The small intestine plays a key role in the pathogenesis of multiple organ failure following circulatory shock. Current results show that reduced perfusion of the small intestine compromises the mucosal epithelial barrier, and the intestinal contents ...
Altshuler, Angelina E, Heller, Michael J, Modestino, Augusta E, Penn, Alexander H, Richter, Michael D, Schmid-Schönbein, Geert W   +5 more
core   +2 more sources

Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities [PDF]

, 2013
PMCID: PMC3613350This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Bellier, A Milano, A Singh, A Wawrzynow, AM Sherrid, AM Socha, Amanda C. Brown, Anil Kumar Tyagi, CA Pashley, D Weichart, DG Muttucumaru, DL Schuessler, Dorothée L. Schuessler, E Kruger, GR Stewart, H Brotz-Oesterhelt, H Ingvarsson, HI Boshoff, I Levchenko, J Braman, J Kirstein, J Ollinger, J Porankiewicz, JB Andersen, JH Kim, JM Flynn, LE Thomsen, LG Wayne, M Estorninho, M Gomez, MC Blokpoel, ND Rawlings, O Dussurget, P Carroll, P Carroll, P Gueneau de Novoa, R Manganelli, RM Raju, S Ahlawat, S Barik, S Engels, S Engels, S Mehra, S Russo, ST Cole, T Akopian, T Msadek, T Parish, Tanya Parish, Yoann Personne   +49 more
core   +11 more sources

Protease activity of extracellular enzyme produced by B. subtilis isolated from soil [PDF]

, 2017
Background: Proteases produced by enzymatic method are more environments friendly than chemical process, and they have tremendous potential in the leather industry and in other several industries.
Ahamad, T. (Tasnim), alam, M. G. (Md), Alam, M. S. (Mohammad), Hossain, M. J. (Md), Islam, M. S. (Md), Karim, M. R. (Mohammad), Mahmood, M. S. (Mohammad), Maitra, P. (Pulak), Nazmuzzaman, M. (Md), Rahman, S. (Sezanur), uddin, M. E. (Md)   +10 more
core   +1 more source

Proteomic Analysis of Chloroplast-to-Chromoplast Transition in Tomato Reveals Metabolic Shifts Coupled with Disrupted Thylakoid Biogenesis Machinery and Elevated Energy-Production Components [PDF]

, 2012
A comparative proteomic approach was performed to identify differentially expressed proteins in plastids at three stages of tomato(Solanum lycopersicum) fruit ripening (mature-green, breaker, red). Stringent curation and processing of the data from three
Alba, Aldridge, Altschul, Andersson, Andon, Armbruster, Asano, Baginsky, Balmer, Bannai, Barry, Barsan, Benjamini, Benning, Bian, Birtić, Blanke, Booth, Botella-Pavía, Bouvier, Bouyssié, Bramley, Bräutigam, Cai, Camara, Chen, Chen, Cho, Deborde, Delmar, Delmar, Demartini, Dieterle, Egea, Egea, Emanuelsson, Emes, Fan, Faurobert, Ferro, Fischer, Harris, Heazlewood, Heazlewood, Hetherington, Huang, Issaq, Jebanathirajah, Jeong, Jimenez, Kahlau, Kato, Kato, Kleffmann, Krech, Lee, Li, Li, Liu, Liu, Liu, Ljubesić, Lopez-Juez, Lundquist, Lytovchenko, Maple, Maple, Marano, McAndrew, Millar, Moing, Neta-Sharir, Niewiadomski, Onishi, Osorio, Palma, Paoletti, Pech, Peng, Pierleoni, Pirrello, Plücken, Ren, Richly, Rocco, Rutschow, Schauer, Seigneurin-Berny, Shipman-Roston, Siddique, Simkin, Small, Smith, Spurr, Su, Sun, Suzuki, Thelen, Thimm, Thomson, Tiwari, Torgrip, van Wijk, Vitha, von Zychlinski, Waters, Yakir-Tamang, Zeng, Zhang, Zhu, Zybailov   +110 more
core   +1 more source

Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase [PDF]

, 2013
There is rapidly mounting evidence that intracellular proteases in bacteria are compelling targets for antibacterial drugs. Multiple reports suggest that the human pathogen Mycobacterium tuberculosis and other actinobacteria may be particularly sensitive
Compton, Corey L., Sauer, Robert T., Schmitz, Karl R., Sello, Jason K.   +3 more
core   +1 more source

Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA.

PLoS ONE, 2008
Exported proteases of Helicobacter pylori (H. pylori) are potentially involved in pathogen-associated disorders leading to gastric inflammation and neoplasia. By comprehensive sequence screening of the H. pylori proteome for predicted secreted proteases,
Martin Löwer, Christiane Weydig, Dirk Metzler, Andreas Reuter, Anna Starzinski-Powitz, Silja Wessler, Gisbert Schneider   +6 more
doaj   +1 more source