Results 71 to 80 of about 89,609 (343)

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

In vitro mammary gland model: establishment and characterization of a caprine mammary epithelial cell line

Acta Agriculturae Slovenica, 2009
Demanding transcriptomic studies in combination with challenging experiments in livestock animal species could be replaced by good in vitro models mimicking the function of ruminant mammary gland.
Jernej OGOREVC, Sonja PRPAR, Peter DOVČ
doaj   +1 more source

Phosphorylation‐Dependent Stabilization of Collaborator of ARF (CARF) Suppresses Lymphoma Cell Proliferation

Advanced Science, EarlyView.
This study revealed that oncogene Collaborator of ARF (CARF) is closely related to B‐cell lymphoma tumorigenesis, and shares a conserved mechanism regulating protein stability with Arabidopsis Kip‐Related Protein6 (KRP6) through casein kinase 1‐mediated phosphorylation. Reduced phosphorylation led to the enhanced protein stability of CARF, resulting in
Li Qu, Zhuang Wei, Shuting Zhou, Xiaofan Zhang, Wenjun Zhang, Aibin Liang, Zhe Wang, Hongwei Xue   +7 more
wiley   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

Twinkle Light‐Inspired Aggregation‐Induced Emission “Lighting‐Up” Bacteriophages to Enhance Immunoassays via Spontaneous Amino‐Yne Click Reaction

Aggregate, EarlyView.
Herein, we present a twinkle‐light‐inspired “lighting‐up” bifunctional bacteriophage for fluorescence immunoassays via a spontaneous amino‐yne click reaction, and demonstrate its versatile potential for the highly sensitive detection of various targets, ranging from small molecules to pathogenic microorganisms, in complex samples.
Xiaoyi Lv, Xirui Chen, Qi Chen, Qing Liu, Mingjian Yao, Weipeng Tong, Hao Fang, Yiping Chen, Yonghua Xiong, Ben Zhong Tang, Xiaolin Huang   +10 more
wiley   +1 more source

Identification of A1/A2 β-Casein Genotypes and Comparison of Their Digestive Properties

Shipin gongye ke-ji
A1 β-casein and A2 β-casein produce different substances after digestion due to differences in primary structure. To more comprehensively explore the possible biological activity effects on the human body, by analyzing and monitoring the changes of this ...
Shihang LI, Hongtao XU, Xiao LI, Meiling SUN, Xinyan YANG, Pengyu XIANG, Zhihao YANG, Chaoxin MAN, Yujun JIANG   +8 more
doaj   +1 more source

Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk

Journal of Advanced Research, 2017
Angiotensin-converting enzyme (ACE) plays a central role in blood pressure regulation by producing the vasoconstrictor angiotensin II. The inhibition of ACE with natural inhibitors, as alternatives to avoid the side effect of synthetic drugs, is a major ...
Hisham R. Ibrahim, Ahmed S. Ahmed, Takeshi Miyata   +2 more
doaj   +1 more source

MODIFICATION OF IgE BINDING TO β- AND αS1-CASEINS BY PROTEOLYTIC ACTIVITY OF LACTOBACILLUS HELVETICUS A75

, 2013
Proteolytic activity of Lactobacillus helveticus A75 and effects of caseins hydrolysis by this strain on their immuno-reactivity were studied. Proteases of L.
A. Ahmadova, S. El-Ghaish, Y. Choiset, H. Rabesona, M. Drouet, J. Chobert, A. Kuliev, T. Haertlé   +7 more
semanticscholar   +1 more source

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

Angewandte Chemie International Edition, Accepted Article.
High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS’s ability to directly assess drug‐protein interactions at endogenous levels, particularly in subcellular contexts.
Shuqi Li, Hong-Rui Zhang, Yang Yang, Ben Chi-Bun Ko, Jin Shang, Haijun Guo, Dan Yang, Mankin Wong, Ricky Wing-Cheung Chan, Karen Ka-Yan Kung, Qian Zhao   +10 more
wiley   +1 more source

Casein genetic polymorphisms in goat breeds of Lombardy

Italian Journal of Animal Science, 2010
In the last years, the genetic polymorphism of goat caseins has raised a considerable research interest due to relationships with milk quality and technological properties (Martin et al., 2002). The four caseins, αs1-casein (CSN1S1), β-casein (
G. Pagnacco, A. Caroli, P. Bolla, F. Chiatti, S. Chessa   +4 more
doaj   +1 more source