Results 1 to 10 of about 514,126 (359)
Nature Communications, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Lindsey Mayes +2 more
exaly +2 more sources
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
Science, 2018 Caspase-8 is a player in pyroptosis The activation of certain pattern-recognition receptors by pathogen-associated molecular patterns results in the formation of inflammasome complexes.
Pontus Orning +2 more
exaly +2 more sources
Molecules, 2021 Cancer has always been one of the most common malignant diseases in the world. Therefore, there is an urgent need to find potent agents with selective antitumor activity against cancer cells.
Xiaoman Ju +7 more
doaj +1 more source
Pharmaceuticals, 2023 In this study, a novel compound was isolated, identified, and its chemical structure was determined from the extract of the roots of Senna velutina.
David Tsuyoshi Hiramatsu Castro +8 more
doaj +1 more source
Molecules, 2020 The global incidence of breast cancer has increased. However, there are many impediments to the development of safe and effective anticancer drugs. The aim of the present study was to evaluate the effect of aviculin isolated from Lespedeza cuneata (Dum ...
Dahae Lee +7 more
doaj +1 more source
Autophagy impairment in human bile duct carcinoma cells
Frontiers in Physiology, 2023 Bile duct epithelial cells, named cholangiocytes, may undergo a neoplastic transformation leading to cholangiocarcinoma. The role autophagy plays in cancer is still debated and few information are available in cholangiocarcinoma. We report in vitro data,
Simonetta Petrungaro +5 more
doaj +1 more source
Anti-Tumor Activity of Atractylenolide I in Human Colon Adenocarcinoma In Vitro
Molecules, 2020 Atractylodes macrocephala is known to exhibit multi-arrays of biologic activity in vitro. However, detail of its anti-tumor activity is lacking. In this study, the effects of atractylenolide I (AT-I), a bio-active compound present in Atractylodes ...
Ka Woon Karen Chan +2 more
doaj +1 more source
The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer
Cell Death Discovery, 2020 Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation.
Mingxia Jiang +3 more
semanticscholar +1 more source
Fas induces apoptosis in human coronary artery endothelial cells in vitro
BMC Cell Biology, 2004 Background Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant.
Wang Rongqi +5 more
doaj +1 more source