Results 161 to 170 of about 318,537 (297)

Investigation of caspase-1 activity and interleukin-1β production in murine macrophage cell lines infected with Leishmania major

, 2014
Mohammad Reza Mahmoudian Sani, Mehrdad Moosazadeh Moghaddam, Hossein Aghamollaei, Kazem Hassanpour, Ramezan Ali Taheri, Gholamreza Farnoosh   +5 more
openalex   +1 more source

The in vitro Mycobacterium bovis BCG Moreau infection of human monocytes that induces Caspase-1 expression, release and dependent cell death is mostly reliant upon cell integrity [PDF]

, 2019
Paulo R. Z. Antas, Carlos Ponte, Matheus R. Almeida, Lawrence H. P. Albuquerque, Periela S. Sousa-Vasconcelos, Thaize Quiroga Chometon, Nilton Nonato da Costa Gomes, Otacílio C. Moreira, Fernanda Carolina da Silva, L.R.R. Castello-Branco, Rosa T. Pinho   +10 more
openalex   +1 more source

Caspase-1 inhibition by YVAD generates tregs pivoting IL-17 to IL-22 response in β-glucan induced airway inflammation

, 2022
Divyesh Patel, Naveen Challagundla, Dipeeka Mandaliya, Shivani Yadav, Omkar Naik, Parameswar Dalai, Dhruvi Shah, Hima Vora, Reena Agrawal-Rajput   +8 more
openalex   +2 more sources

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats. [PDF]

Clin Sci (Lond)
León Silva AH, Tian R, Ballengee S, Jamal A, Menon S, Chalikonda SV, Lassance-Soares RM, Tan A, Duara J, Schmidt A, Young K, Wu S, Ziebarth N, Benny M.   +13 more
europepmc   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Picroside II Alleviates the Progression of Alzheimer's Disease via the NLRP3/Caspase-1/GSDMD Pathway. [PDF]

Neuromolecular Med
Li S, Gao Y, Zhang Y, Zhang J, Zhao Y, Chang C, Gao X, Zhang J, Yang G.   +8 more
europepmc   +1 more source

Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6 [PDF]

, 2009
Emilie Giaime, Claire Sunyach, C. Druon, Sabine Scarzello, Guillaume Robert, Sébastien Grosso, Patrick Auberger, Matthew S. Goldberg, Jie Shen, Peter Heutink, Jacques Pouysségur, Gilles Pagès, Frédéric Checler, Cristine Alvès da Costa   +13 more
openalex   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

Predictive Value of Pyroptosis Markers (NLRP3, HMGB1, and Caspase-1) in the Prognosis of Patients With Metastatic Breast Cancer: A Prospective Observational Study. [PDF]

Breast J
Zhang Y, He Y, Liu Q, Deng H.
europepmc   +1 more source