Results 141 to 150 of about 21,606,107 (313)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Caspase-8 is not activated by caspase-3.

, 2017
(A) Microscopic images of cells expressing FRET-Bid in the absence or presence of Ac-DEVD-CHO (caspase-3 inhibitor, 20 μM) in Huh-7 and HepG2 cells.
Liping Wu (578606), Tongsheng Chen (394172), Gaina Xi (3330204), Yilin Pang (3330201), Guiqi Qin (3737875), Xiaoping Wang (110673), Shengnan Wu (2299912)   +6 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells

, 2016
BackgroundHuman periodontal ligament (PDL) cells underwent apoptosis after mechanical stretch loading. However, the exact signalling pathway remains unknown.
Chun Xu (286394), Fuqiang Zhang (404974), Dan Zhao (285025), Jiabao Zhuang (3394868), Yaqin Wu (275577)   +4 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures

, 2010
Background The xylem vascular system is composed of fused dead, hollow cells called tracheary elements (TEs) that originate through trans-differentiation of root and shoot cambium cells. TEs undergo autolysis as they differentiate and mature.
Elena T Iakimova, Ernst J Woltering, Qian Tian, Twumasi, P., Schel Jan HN, Emons, A.M.C., Wim van Ieperen, Olaf van Kooten, van Ieperen Wim, van Kooten, O., van Ieperen, W., Iakimova, E.T., van Kooten Olaf, Qian, T., Emons Anne, Schel, J.H.N., Peter Twumasi, Tian Qian, Iakimova Elena T, Woltering, E.J., Anne Emons, Kooten, O., van, Ieperen, W., van, Anne MieC Emons, Twumasi Peter, Woltering Ernst J, Jan HN Schel   +26 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Novel perspectives on non-canonical inflammasome activation

ImmunoTargets and Therapy, 2015
Catherine Emma Diamond,1,2 Hanif Javanmard Khameneh,1 David Brough,2 Alessandra Mortellaro,1 1Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore; 2Faculty of Life Sciences, University of Manchester ...
Diamond CE, Khameneh HJ, Brough D, Mortellaro A   +3 more
doaj  

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation.

, 2001
Ligation of the cell-surface Fas molecule by its ligand (Fas-L) or agonistic anti-Fas monoclonal antibodies results in the cleavage and activation of the cysteine protease procaspase 8 followed by the activation of procaspase 3 and by apoptosis.
Jones, DT, Ganeshaguru, K, Mehta, AB, Prentice, HG, Virchis, AE, Lowdell, MW, Wickremasinghe, RG, Hoffbrand, AV, Folarin, NI   +8 more
core  

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

, 2018
Infection with Burkholderia pseudomallei or B. thailandensis triggers activation of the NLRP3 and NLRC4 inflammasomes leading to release of IL-1β and IL-18 and death of infected macrophages by pyroptosis, respectively.
Fabio Re, Jinyong Wang (112096), Manoranjan Sahoo, Jinyong Wang, Hector Cordero (5264579), Jonathan Warawa, Hector Cordero, Kelly Deobald (5264576), Louis Lantier (499627), Louis Lantier, Fabio Re (189981), Manoranjan Sahoo (189969), Jonathan Warawa (5264573), Kelly Deobald   +13 more
core   +1 more source