Neonatal-onset multisystem inflammatory disease responsive to interleukin-1 beta inhibition [PDF]
, 2006 BACKGROUND:Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation.
Adams, BS +39 more
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Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming
Advanced Materials, EarlyView.Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung +6 more
wiley +1 more source
A Signal for the Caspase-1 Inflammasome Free of TLR [PDF]
, 2007 Charles A. Dinarello
openalex +1 more source
Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages [PDF]
, 2020 Cuiping Zhang +8 more
openalex +1 more source
The NLRP3-Inflammasome-Caspase-1 Pathway Is Upregulated in Idiopathic Pulmonary Fibrosis and Acute Exacerbations and Is Inducible by Apoptotic A549 Cells [PDF]
, 2021 Benedikt Jäger +7 more
openalex +1 more source
Advanced Materials Technologies, EarlyView.A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey +6 more
wiley +1 more source
RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Advanced Science, EarlyView.Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
Cardiolipin Provides a Platform for Caspase-1 Activation and NLRP3 Inflammasome Assembly [PDF]
, 2016 Suzanne L. Cassel +3 more
openalex +1 more source
Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer [PDF]
, 2021 Honglin Yan +8 more
openalex +1 more source
Molecular Medicine ReportsMacrophage pyroptosis mediates vascular inflammation and atherosclerosis (AS). Hydrogen sulfide (H2S) exerts a protective role in preventing inflammation and AS. However, its molecular mechanisms of regulating the pyroptosis signaling pathway and inhibiting macrophage pyroptosis remain unexplored.
Jia, Zhenli +8 more
openaire +2 more sources