Results 301 to 310 of about 24,095,126 (372)

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

Cell Death and Differentiation, 2015
V. Kaushal, V. Kaushal, Rebecca Dye, Prateep Pakavathkumar, Prateep Pakavathkumar, B. Foveau, B. Foveau, Joseph Flores, Joseph Flores, B. Hyman, B. Ghetti, B. Koller, A. LeBlanc, A. LeBlanc   +13 more
semanticscholar   +1 more source

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Correction to "Adipose Tissue IL-18 Production Is Independent of Caspase-1 and Caspase-11". [PDF]

Immun Inflamm Dis
europepmc   +1 more source

Caspase-1-dependent spatiality in triple-negative breast cancer and response to immunotherapy. [PDF]

Nat Commun
Zheng W, Marini W, Murakami K, Sotov V, Butler M, Gorrini C, Ohashi PS, Reedijk M.   +7 more
europepmc   +1 more source

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+ Efflux

Journal of Immunology, 2015
Mausita Karmakar, Michael A. Katsnelson, H. Malak, Neil G. Greene, S. Howell, A. Hise, A. Camilli, A. Kadioglu, G. Dubyak, E. Pearlman   +9 more
semanticscholar   +1 more source

Nanoscale Metal‐Organic Framework‐Based Self‐Monitoring Oxygen Economizer and ROS Amplifier for Enhanced Radiotherapy‐Radiodynamic Therapy

Advanced Science, EarlyView.
A Fe (III)–Pt (II) porphyrin framework‐based radiosensitizer (FPTM‐LP) is constructed to serve as an oxygen economizer, hypoxia self‐monitoring device, and reactive oxygen species (ROS) amplifier. The glutathione (GSH)/pH‐responsive release of lonidamine achieves oxygen‐economization to combat hypoxia‐induced radioresistance guided by near infrared ...
Shiye Du, Qiang Wen, Ting Han, Jiongyu Ren, Mingyu Wang, Yunpeng Dai, Xiaoguang Ge, Lu Li, Junzhi Liu, Shi Gao   +9 more
wiley   +1 more source

Phenylethyl isothiocyanate mitigates drug-induced liver injury in mice by inhibiting hepatocyte pyroptosis through the NLRP3-caspase-1-GSDMD pathway. [PDF]

Front Pharmacol
An N, Wang X, Qin J, Cheng M, Bai M, Cheng J, Xu Q, Wu X.   +7 more
europepmc   +1 more source

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway

Arteriosclerosis, Thrombosis and Vascular Biology, 2015
Ying-Xuan Yin, Xinyuan Li, Xiaojin Sha, Hang Xi, Ya-feng Li, Ying Shao, J. Mai, A. Virtue, Jahaira Lopez‐Pastrana, Shu Meng, D. Tilley, M. A. Monroy, Eric T. Choi, Craig J. Thomas, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +16 more
semanticscholar   +1 more source

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Advanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang   +11 more
wiley   +1 more source

Pretreatment with <i>Citrus reticulata</i> 'Chachi' Polysaccharide Alleviates Alcohol-Induced Gastric Ulcer by Inhibiting NLRP3/ASC/Caspase-1 and Nrf2/HO-1 Signaling Pathways. [PDF]

Nutrients
Liang H, Liang Y, Wu L, Lin L, Yao Y, Deng J, Xu J, Li H, Gao F, Xing W, Yu M, Jia X, Wei M, Li C, Zheng G.   +14 more
europepmc   +1 more source