Results 301 to 310 of about 341,145 (337)

Microglia Drive Peripapillary Vascular Density Reduction in Normal Tension Glaucoma by Regulating the Rpl17/Stat5b/Apoa1 Axis

Advanced Science, EarlyView.
This study revealed that E50K mutant microglia drive retinal peripapillary vascular density reduction in NTG via the Rpl17/Stat5b/Apoa1 axis and identified Apoa1 as a novel suppressor of retinal vascular endothelial cells. These findings identify a potential therapeutic target for glaucoma and support the clinical potential of EA for protecting RGCs ...
Di Zhang, Sisi Chen, Yanfeng Zhang, Leyi Qiu, Mengxian Du, Wulian Song, Fengyi Guo, Jingyang Zhang, Xinna Liu, Huiping Yuan   +9 more
wiley   +1 more source

HIV-1 and SIV Infection are associated with early loss of lung interstitial CD4+ T cells and dissemination of pulmonary tuberculosis [PDF]

, 2019
et al,, Khader, Shabaana A
core   +1 more source

Mesenchymal Stem Cells Derived from Different Adipose Tissue Depots Ameliorate Severe Acute Pancreatitis by Inhibiting NF-κB/NLRP3/Caspase-1 Pathways. [PDF]

Stem Cell Rev Rep
Wang A, An Y, Wang X, Gou W, Xu F, Li Y, Wang C, Tu Z, Hou W, Cui Y.   +9 more
europepmc   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

Caspase-1-dependent spatiality in triple-negative breast cancer and response to immunotherapy. [PDF]

Nat Commun
Zheng W, Marini W, Murakami K, Sotov V, Butler M, Gorrini C, Ohashi PS, Reedijk M.   +7 more
europepmc   +1 more source

Peptide Electrostatic Modulation Directs Human Neural Cell Fate

Advanced Science, EarlyView.
This study explores the effect of charge on the bioactivity of peptide‐based supramolecular materials. The design of a peptide library with varying charges that self‐assemble into supramolecular fibers is presented, demonstrating how the surface charge of these fibers, used as artificial extracellular matrices, influences the fate of human neural ...
Laura Perez‐Chirinos, Xavier Barceló, M. Gabriella Chiariello, Irene Sanz, Amaia Iturrospe, Arantxa Arbe, J. Alberto Ortega, Siewert J. Marrink, Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli   +10 more
wiley   +1 more source

Amantadine reduces sepsis-induced brain injury via NLRP3/caspase-1 inflammasome activation. [PDF]

Iran J Basic Med Sci
Karabacak P, Bindal A, Ozcan MS, Ilhan I, Tepebasi MY, Arlioğlu M, Taner R, Asci H.   +7 more
europepmc   +1 more source

A “3+2” Cooperation Pattern of Amphipathic AIE Phototheranostic System for Multimodal Image‐Guided Synergistic Type I/II Photodynamic‐Photothermal Therapy

Advanced Science, EarlyView.
A “3+2” cooperation pattern of amphipathicity PTA (named TDTMSB) with aggregation‐induced emission (AIE) features is designed and synthesized to perform near‐infrared I/II fluorescence imaging, photoacoustic imaging, photothermal imaging, and Type I/II photodynamic therapy (PDT)‐photothermal therapy (PTT) synergistic phototherapy for malignant tumors ...
Haijun Ma, Yibo An, Yuanyuan Han, Feifan Zhao, Yunfei Zuo, Guokang He, Zhixiang Lu, Ryan T. K. Kwok, Jianwei Sun, Jacky W. Y. Lam, Yen Wei, Ben Zhong Tang   +11 more
wiley   +1 more source

Correction to "Adipose Tissue IL-18 Production Is Independent of Caspase-1 and Caspase-11". [PDF]

Immun Inflamm Dis
europepmc   +1 more source

The Effects of Xialiqi Capsules in Regulating the Pyroptosis of Prostate Epithelial Cells Via NLRP3/Caspase-1 Pathway for the Treatment of Chronic Prostatitis. [PDF]

Am J Mens Health
Hong Z, Chen Z, Chen W, Qiu J, Wang S, Wei Y, Guo J.   +6 more
europepmc   +1 more source