Results 271 to 280 of about 4,015,701 (290)

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Pyroptosis by caspase-11 inflammasome-Gadermin D pathway in autoimmune diseases.

Pharmacological Research, 2021
Inflammasomes are a group of supramolecular complexes primarily comprise a sensor, adaptor protein and an effector. Among them, canonical inflammasomes are assembled by one specific pattern recognition receptor, the adaptor protein apoptosis-associated ...
Jiasi Wu, Jiayi Sun, Xianli Meng
semanticscholar   +3 more sources

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Non-canonical inflammasome activation targets caspase-11

Nature, 2011
Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is believed to be essential for production of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 during the innate immune response.
N. Kayagaki, S. Warming, M. Lamkanfi, L. Walle, S. Louie, Jennifer Dong, K. Newton, Yan Qu, Jinfeng Liu, Sherry Heldens, Juan Zhang, Wyne P. Lee, M. Roose-Girma, V. Dixit   +13 more
semanticscholar   +4 more sources

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nature, 2015
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse caspase-11, causing pyroptotic cell death, interleukin-1β processing, and lethal septic shock.
N. Kayagaki, Irma B. Stowe, Bettina L. Lee, K. O’Rourke, Keith Anderson, S. Warming, Trinna L Cuellar, B. Haley, M. Roose-Girma, Q. Phung, Peter S. Liu, J. Lill, Hong Li, Jiansheng Wu, S. Kummerfeld, Juan Zhang, Wyne P. Lee, S. Snipas, G. Salvesen, L. X. Morris, L. Fitzgerald, Yafei Zhang, E. Bertram, C. Goodnow, V. Dixit   +24 more
semanticscholar   +4 more sources

Caspase-11–Dependent Pyroptosis

Science Signaling, 2013
Caspase-11 triggers cell death in response to bacteria that gain access to the cytosol of macrophages.
openaire   +2 more sources

Caspase‐11: The driving factor for noncanonical inflammasomes

European Journal of Immunology, 2013
Inflammasomes are large multiprotein platforms that mediate the processing of caspase‐1, which in turn promotes the maturation and release of IL‐1β and IL‐18 in response to microbial and danger signals. While the canonical pathway of inflammasome activation has been known for some time, a novel mechanism of noncanonical inflammasome activation mediated
Elena, Viganò, Alessandra, Mortellaro
openaire   +2 more sources

PARP-1 regulates the expression of caspase-11

Biochemical and Biophysical Research Communications, 2011
Poly(ADP-ribose) polymerase-1 (PARP-1) is a multifunctional enzyme that regulates DNA repair, cell death and transcription of inflammatory proteins. In the present study, we present evidence that PARP-1 regulates the expression of caspase-11 following lipopolysaccharide (LPS) stimulation.
Lang, Yoo, Seokheon, Hong, Ki Soon, Shin, Shin Jung, Kang   +3 more
openaire   +2 more sources

Complementing caspase 11

Science Signaling, 2016
Complement signaling increases caspase 11–dependent cell death and worsens sepsis.
openaire   +1 more source

Caspase‐11: arming the guards against bacterial infection

Immunological Reviews, 2015
SummaryAs a front line of defense against pathogenic microbes, our body employs a primitive, yet highly sophisticated and potent innate immune response pathway collectively referred to as the inflammasome. Innate immune cells, epithelial cells, and many other cell types are capable of detecting infection or tissue injury and mounting a coordinated ...
Irma, Stowe, Bettina, Lee, Nobuhiko, Kayagaki   +2 more
openaire   +2 more sources