Results 281 to 290 of about 4,015,701 (290)

Suppression of caspase-11 expression by histone deacetylase inhibitors

Biochemical and Biophysical Research Communications, 2009
It has been well documented that histone deacetylase inhibitors suppress inflammatory gene expression. Therefore, we investigated whether histone deacetylase inhibitors modulate the expression of caspase-11 that is known as an inducible caspase regulating both inflammation and apoptosis.
Hyejung, Heo, Lang, Yoo, Ki Soon, Shin, Shin Jung, Kang   +3 more
openaire   +2 more sources

Cathepsin B-Mediated Activation of the Proinflammatory Caspase-11

Biochemical and Biophysical Research Communications, 1998
Members of the caspase (CASP) family of cysteine proteases can be subdivided in proapoptotic caspases and proinflammatory caspases. Whereas the apical activation pathways for the caspases that are involved in the execution of the apoptotic process are beginning to be understood, the pathways that lead to the activation of proinflammatory caspases are ...
P, Schotte, W, Van Criekinge, M, Van de Craen, G, Van Loo, M, Desmedt, J, Grooten, M, Cornelissen, L, De Ridder, J, Vandekerckhove, W, Fiers, P, Vandenabeele, R, Beyaert   +11 more
openaire   +2 more sources

Caspase-11 Is Not Necessary for Chemotherapy-Induced Intestinal Mucositis

DNA and Cell Biology, 2004
Mucositis is a common, dose-limiting toxicity associated with drug and radiation therapy for cancer. The ulcerative lesions of mucositis serve as systemic portals of entry for the micro-organisms that inhabit the mucosa of the gastrointestinal tract and the oral cavity, often leading to systemic infection.
Shin-Jung, Kang, Rishi, Popat, Christopher, Bragdon, Kathryn, Odonnell, Sally, Phelan, Junying, Yuan, Stephen T, Sonis   +6 more
openaire   +2 more sources

Anti-inflammatory role of Artemisia argyi methanol extract by targeting the caspase-11 non-canonical inflammasome in macrophages.

Journal of Ethnopharmacology, 2023
Y. B. Kim, Hui-Jin Cho, Young-Su Yi
semanticscholar   +1 more source

Inhibition of caspase-11 under inflammatory conditions suppresses chondrogenic differentiation

Tissue and Cell
Caspase-11 is the murine homologue of human caspases-4 and -5 and is involved in mediating the inflammatory response. However, its functions are often confused and misinterpreted with the more important and better described caspase-1. Therefore, this study focused exclusively on the specific roles of caspase-11, both in cartilage formation and in the ...
Barbora, Veselá, Jana, Bzdúšková, Alice, Ramešová, Eva, Švandová, Susanne, Grässel, Eva, Matalová   +5 more
openaire   +2 more sources

Moving away from death: when caspase-11 meets cofilin

Nature Cell Biology, 2007
Lymphocyte migration is activated in response to inflammation and largely depends on the modulation of actin dynamics, and remodelling of the cytoskeleton, following cytokine stimulation. A novel pathway modulating inflammatory-cell migration in vivo that involves the unlikeliest of partners, the inflammatory caspase-11 and Aip1 (an activator of ...
openaire   +1 more source

Luteolin activates Tregs to promote IL-10 expression and alleviating caspase-11-dependent pyroptosis in sepsis-induced lung injury.

International Immunopharmacology, 2021
Zheng Zhang, Dan Zhang, Ke Xie, Chuanjiang Wang, Fang Xu   +4 more
semanticscholar   +1 more source

An Inactivating Caspase-11 Passenger Mutation Muddles Sepsis Research

American Journal of Respiratory and Critical Care Medicine, 2013
Tom, Vanden Berghe, Alain, Goethals, Dieter, Demon, Pieter, Bogaert, Tak W, Mak, Anje, Cauwels, Peter, Vandenabeele   +6 more
openaire   +2 more sources

Caspase-11

2009
openaire   +1 more source

Innate immunity: Caspase 11 hunts down cytosolic bacteria.

Nature reviews. Immunology, 2013
openaire   +1 more source